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NCT07434843 · ClinicalTrials.gov registry record · Phase 2
PH 2 Pemigatinib in SDH-deficient GIST
A Phase 2 study, sponsored by Dana-Farber Cancer Institute.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 24
- Enrollment target
NCT07434843: Recruiting Phase 2 study, sponsored by Dana-Farber Cancer Institute.
NCT07434843 is a Phase 2 study that is actively recruiting participants, run by Dana-Farber Cancer Institute. The registered enrollment target is 24 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07434843, a Phase 2 study, is actively recruiting participants, sponsored by Dana-Farber Cancer Institute.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 24 participants
- Enrollment target
Study Summary
The purpose of this study is to determine how effective the drug pemigatinib is as a treatment option for advanced succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors(GIST). This study will also assess the side effects associated with pemigatinib and evaluate its tolerability. The name of the study drug involved in this study is: • Pemigatinib (INCB054828)
Primary Outcome
The objective response rate is defined as the rate of participants with a complete response or partial response, calculated using RECIST 1.1.
Interventions
- DRUG Pemigatinib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2026-05-19 |
| Est. Completion | 2029-04-01 |
| Phase | Phase 2 |
What NCT07434843 shows while recruiting
NCT07434843 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 1 intervention - of which Pemigatinib is the first listed.
NCT07434843 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07434843 about?
NCT07434843 is a clinical study titled "PH 2 Pemigatinib in SDH-deficient GIST". The purpose of this study is to determine how effective the drug pemigatinib is as a treatment option for advanced succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors(GIST). This study will also assess the side effects associated with pemigatinib and evaluate its tolerability. T...
What is the current status of trial NCT07434843?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2026-05-19. Estimated completion is 2029-04-01.
What interventions are being tested in trial NCT07434843?
The interventions under investigation include: Pemigatinib (DRUG).
Who is sponsoring clinical trial NCT07434843?
This trial is sponsored by Dana-Farber Cancer Institute, which has 781 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07434843's enrollment target sits among peer trials
24 1756th of 2000 higher than 217 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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