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NCT00005585 · ClinicalTrials.gov registry record · Phase 3
Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
A Phase 3 study, sponsored by Children's Oncology Group.
- Completed
- Registry status
- Phase 3
- Development phase
- 838
- Enrollment target
NCT00005585: Completed Phase 3 study, sponsored by Children's Oncology Group.
NCT00005585 is a Phase 3 study that has completed, run by Children's Oncology Group. The registered enrollment target is 838 participants, roughly in line with the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00005585, a Phase 3 study, has completed, sponsored by Children's Oncology Group.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 838 participants
- Enrollment target
Study Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of combination chemotherapy is more effective for childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different regimens of combination chemotherapy to see how well they work in treating children with acute lymphoblastic leukemia.
Primary Outcome
The test statistic will compare Kaplan-Meier curves with sample size derived from a modification of the Makuch-Simon method for historical controls
Interventions
- DRUG cyclophosphamide
- DRUG dexamethasone
- DRUG leucovorin calcium
- DRUG cytarabine
- DRUG daunorubicin hydrochloride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 838 participants |
| Start Date | 2000-04 |
| Phase | Phase 3 |
What the finished NCT00005585 record still lists
NCT00005585 is an interventional study that assigns participants to a tested intervention. The registered 838 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target.
The record links to 0 conditions, and to 5 interventions - of which cyclophosphamide is the first listed.
NCT00005585 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00005585 about?
NCT00005585 is a clinical study titled "Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia". RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of combination chemotherapy is more effective for childhood acute lymphoblastic leukemia...
What is the current status of trial NCT00005585?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 838 participants. The study started on 2000-04.
What interventions are being tested in trial NCT00005585?
The interventions under investigation include: cyclophosphamide (DRUG), dexamethasone (DRUG), leucovorin calcium (DRUG), cytarabine (DRUG), daunorubicin hydrochloride (DRUG).
Who is sponsoring clinical trial NCT00005585?
This trial is sponsored by Children's Oncology Group, which has 342 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00005585's enrollment target sits among peer trials
838 394th of 2000 higher than 1,606 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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