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NCT03174288 · ClinicalTrials.gov registry record · NA
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
A NA study of Type 1 Diabetes, sponsored by University of Virginia.
- Completed
- Registry status
- NA
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT03174288: Completed NA study of Type 1 Diabetes, sponsored by University of Virginia.
NCT03174288 is a NA study of Type 1 Diabetes that has completed, run by University of Virginia. The registered enrollment target is 32 participants, below the 767-participant average among 198 other Type 1 Diabetes trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03174288, a NA study of Type 1 Diabetes, has completed, sponsored by University of Virginia.
- COMPLETED
- Registry status
- NA
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
In this protocol, 60 subjects with DM1 will be studied at baseline, after 12 weeks of MCR blockade or 12 weeks of exercise, and again after an additional 12 weeks of MCR blockade, exercise or the combination of both interventions. The investigators will assess function in conduit (pulse wave velocity-PWV, flow-mediated dilation-FMD and augmentation index-AI), resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-CEU) vessels before and after 2 hrs of a euglycemic insulin clamp. We hypothesize that compared to healthy controls, both baseline and insulin-responsive vascular function are impaired throughout the arterial vasculature by DM1 and that exercise training and/or mineralocorticoid receptor (MCR) blockade will improve both baseline and insulin-responsive pan-arterial function.
Primary Outcome
measured at baseline and 24 weeks
Conditions Studied
Interventions
- OTHER Exercise
- DRUG Spironolactone
Study Locations (1)
Virginia
- University of Virginia - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2015-08 |
| Est. Completion | 2019-05-22 |
| Phase | NA |
What the finished NCT03174288 record still lists
NCT03174288 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 767-participant average among 198 other Type 1 Diabetes trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Type 1 Diabetes appearing as the primary indexed condition, and to 2 interventions - of which Exercise is the first listed.
NCT03174288 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT03174288 about?
NCT03174288 is a clinical study titled "The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes". In this protocol, 60 subjects with DM1 will be studied at baseline, after 12 weeks of MCR blockade or 12 weeks of exercise, and again after an additional 12 weeks of MCR blockade, exercise or the combination of both interventions. The investigators will assess function in conduit (pulse wave velocit...
What is the current status of trial NCT03174288?
This trial is currently completed. It is a NA study. The enrollment target is 32 participants. The study started on 2015-08. Estimated completion is 2019-05-22.
What conditions does trial NCT03174288 study?
This clinical trial studies the following conditions: Type 1 Diabetes.
What interventions are being tested in trial NCT03174288?
The interventions under investigation include: Exercise (OTHER), Spironolactone (DRUG).
Who is sponsoring clinical trial NCT03174288?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03174288 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Type 1 Diabetes
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Where NCT03174288's enrollment target sits among peer trials
32 124th of 198 higher than 73 of 198 other Type 1 Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Type 1 Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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