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Triple Negative Breast Cancer clinical trials
68 of 119 indexed Triple Negative Breast Cancer trials are currently recruiting.
119 US clinical trials · 68 currently recruiting
Triple Negative Breast Cancer is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 68 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 98 in Phase 1-2 (earlier-stage). The most active sponsor is H. Lee Moffitt Cancer Center and Research Institute, running 6 of these trials.
The research picture
Triple Negative Breast Cancer has 119 registered US clinical trials, 68 of them open to new participants right now, about 57% of the total.
- 68
- recruiting participants now
- 57%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 6
- top sponsor: H. Lee Moffitt Cancer Center and Research Institute
Active & Recent Trials
119 total, page 3 of 3
A Study of Atezolizumab in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Participants With Previously Untreated Metastatic Triple-Negative Breast Cancer (IMpassion130)
Hoffmann-La Roche
NCT02425891
Study of XB002 in Subjects With Solid Tumors (JEWEL-101)
Exelixis
NCT04925284
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
Esperas Pharma
NCT02632448
NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors
NeoImmuneTech
NCT04332653
A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands
Novartis Pharmaceuticals
NCT01351103
Phase II ABT-888 With Cyclophosphamide
National Cancer Institute (NCI)
NCT01306032
Study of the Safety, Pharmacokinetics and Efficacy of Tinostamustine in Patients With Advanced Solid Tumors.
Mundipharma Research Limited
NCT03345485
Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
Icahn School of Medicine at Mount Sinai
NCT02247037
INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors
Incyte Corporation
NCT04580485
Safety of TT-00420 (Tinengotinib) Monotherapy in Patients With Advanced Solid Tumors and Triple Negative Breast Cancer
TransThera Sciences (Nanjing)
NCT03654547
A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers
Merrimack Pharmaceuticals
NCT01451632
Open Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-907 in Subjects With Advanced/Relapsed Solid Tumors
Curis
NCT02307240
Study Of Single-dose Cyclophosphamide +Pembrolizumab In Patients With Metastatic Triple Negative Breast Cancer
UNC Lineberger Comprehensive Cancer Center
NCT02768701
TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers
Tempest Therapeutics
NCT03829436
Emotions Immunology and Breast Cancer
Luz A. Venta, MD
NCT03609671
Study of Temsirolimus, Erlotinib and Cisplatin in Solid Tumors
Columbia University
NCT00998036
Carboplatin and Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IIB-IIIC Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT01818063
A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors
Pure Biologics S.A.
NCT06273852
cMet CAR RNA T Cells Targeting Breast Cancer
University of Pennsylvania
NCT01837602
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 70 |
| Phase 2 | 28 |
| Phase 3 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Triple Negative Breast Cancer Trial Landscape
119 indexed Triple Negative Breast Cancer studies · 68 recruiting (57%).
Phase mix: 8 late (III/IV) vs 98 early (I/II).
Top sponsor: H. Lee Moffitt Cancer Center and Research Institute (6 trials), 9 others listed. 19 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Triple Negative Breast Cancer?
PlainTrial tracks 119 US clinical trials for Triple Negative Breast Cancer, of which 68 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Triple Negative Breast Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.