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ClinicalTrials.gov 68 recruiting now official registry

Triple Negative Breast Cancer clinical trials

68 of 119 indexed Triple Negative Breast Cancer trials are currently recruiting.

119 US clinical trials · 68 currently recruiting

Triple Negative Breast Cancer is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 68 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 98 in Phase 1-2 (earlier-stage). The most active sponsor is H. Lee Moffitt Cancer Center and Research Institute, running 6 of these trials.

The research picture

Triple Negative Breast Cancer has 119 registered US clinical trials, 68 of them open to new participants right now, about 57% of the total.

68
recruiting participants now
57%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
6
top sponsor: H. Lee Moffitt Cancer Center and Research Institute
Phase 170Phase 228Phase 38

Active & Recent Trials

119 total, page 3 of 3

COMPLETED Phase 3 902 participants

A Study of Atezolizumab in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Participants With Previously Untreated Metastatic Triple-Negative Breast Cancer (IMpassion130)

Hoffmann-La Roche

NCT02425891

COMPLETED Phase 1 269 participants

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

Exelixis

NCT04925284

COMPLETED Phase 1 229 participants

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Esperas Pharma

NCT02632448

COMPLETED Phase 1 215 participants

NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

NeoImmuneTech

NCT04332653

COMPLETED Phase 1 185 participants

A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands

Novartis Pharmaceuticals

NCT01351103

COMPLETED Phase 2 124 participants

Phase II ABT-888 With Cyclophosphamide

National Cancer Institute (NCI)

NCT01306032

COMPLETED Phase 1 71 participants

Study of the Safety, Pharmacokinetics and Efficacy of Tinostamustine in Patients With Advanced Solid Tumors.

Mundipharma Research Limited

NCT03345485

COMPLETED 68 participants

Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer

Icahn School of Medicine at Mount Sinai

NCT02247037

COMPLETED Phase 1 54 participants

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Incyte Corporation

NCT04580485

COMPLETED Phase 1 48 participants

Safety of TT-00420 (Tinengotinib) Monotherapy in Patients With Advanced Solid Tumors and Triple Negative Breast Cancer

TransThera Sciences (Nanjing)

NCT03654547

COMPLETED Phase 1 48 participants

A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers

Merrimack Pharmaceuticals

NCT01451632

COMPLETED Phase 1 43 participants

Open Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-907 in Subjects With Advanced/Relapsed Solid Tumors

Curis

NCT02307240

COMPLETED Phase 2 40 participants

Study Of Single-dose Cyclophosphamide +Pembrolizumab In Patients With Metastatic Triple Negative Breast Cancer

UNC Lineberger Comprehensive Cancer Center

NCT02768701

COMPLETED Phase 1 38 participants

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Tempest Therapeutics

NCT03829436

COMPLETED NA 17 participants

Emotions Immunology and Breast Cancer

Luz A. Venta, MD

NCT03609671

COMPLETED Phase 1 9 participants

Study of Temsirolimus, Erlotinib and Cisplatin in Solid Tumors

Columbia University

NCT00998036

COMPLETED Phase 2 9 participants

Carboplatin and Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IIB-IIIC Breast Cancer

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT01818063

COMPLETED Early Phase 1 8 participants

A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Pure Biologics S.A.

NCT06273852

COMPLETED Phase 1 6 participants

cMet CAR RNA T Cells Targeting Breast Cancer

University of Pennsylvania

NCT01837602

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Phase Distribution

PhaseTrial count
Phase 1 70
Phase 2 28
Phase 3 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Triple Negative Breast Cancer Trial Landscape

119 indexed Triple Negative Breast Cancer studies · 68 recruiting (57%).

Phase mix: 8 late (III/IV) vs 98 early (I/II).

Top sponsor: H. Lee Moffitt Cancer Center and Research Institute (6 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Triple Negative Breast Cancer?

PlainTrial tracks 119 US clinical trials for Triple Negative Breast Cancer, of which 68 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Triple Negative Breast Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.