Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Substance Use: early-phase trial registry
42 of 89 indexed Substance Use trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #154 of 28,707 conditions by registered trial count.
89 US clinical trials · 42 currently recruiting · #154 of 28,707 conditions by registered trial count
Substance Use: 89 US clinical trials tracked, 42 recruiting.
Substance Use is the subject of 89 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins Bloomberg School of Public Health, running 6 of these trials.
Enrollment posture brief
Registry condition substance-use
OPEN 42 | RECR 47% | LATE 2 | EARLY 4 | RANK #154 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Crohn Disease (47% recruiting · 72 trials)
Substance Use lists 42 open slots (47% of 89 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance Use on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Substance Use is recruiting above its size-band peers.
42 of 89 indexed trials (47.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Substance Use trials is spread across many organizations.
Johns Hopkins Bloomberg School of Public Health accounts for 6 of 89 trials (6.7%). 56 distinct sponsors appear on at least one study for this condition label.
-
Typical Substance Use enrolment sits around 224 participants.
Median target enrolment is 224 among the 89 trials that report a genuine target (sentinel values excluded). 26 of those (29.2%) plan for fewer than 100 participants.
-
Substance Use research is mostly interventional.
84 interventional and 5 observational studies make up this index (94.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
89 total, page 2 of 2
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
University of Michigan
NCT05410561
BrotherlyACT: A Tech-Enhanced Violence and Substance Use Intervention for Black Boys and Young Men
Rush University Medical Center
NCT06359990
Fostering Healthy Futures for Teens: An RCT
University of Denver
NCT03707366
A Brief Intervention for Alcohol Users With Interpersonal Trauma
Western Kentucky University
NCT05414344
Intervention for Virologic Suppression in Youth
University of California, San Francisco
NCT05877729
Neurocognitive Predictors of Health Risk Behaviors
Virginia Polytechnic Institute and State University
NCT06941181
Using the Ending Self-Stigma Intervention to Reduce Internalized Stigma Among People Living With HIV Who Use Substances
Friends Research Institute
NCT05704764
Examining Feasibility and Acceptability of Telemedicine for Substance Use Disorder (SUD)
University of Michigan
NCT04768920
Maternal Brain Imaging in Opioid Use Disorder
Indiana University
NCT06008990
Developing a Telehealth Model to Improve Treatment Access for Rural Veterans With Substance Use Disorders
VA Office of Research and Development
NCT05348317
Rapid Adaptation to Prevent Drug Use
Wayne State University
NCT05806840
Data-driven Identification for Substance Misuse
University of Wisconsin, Madison
NCT03833804
Randomized Trial of the Positive Action Program in Hawaii Schools
National Institute on Drug Abuse (NIDA)
NCT00328445
HOPE Demonstration Field Experiment Multisite Evaluation
RTI International
NCT01670708
Substance Abuse Treatment to HIV Care (SAT2HIV): The Motivational Interviewing-based Brief Intervention Experiment
RTI International
NCT02495402
Adolescent SCreening To Help Eliminate Misuse
Boston Children's Hospital
NCT04200339
Interactive Technology for Media Literacy Drug Prevention in Community Groups
Real Prevention
NCT03157700
Leveraging Social Networks to Increase COVID-19 Testing Uptake
New York State Psychiatric Institute
NCT04873401
Evaluation of an Entrepreneurship Program for American-Indian Youth
Johns Hopkins Bloomberg School of Public Health
NCT02157493
The ProGirls Study
Oregon Research Institute
NCT02112201
Pilot Randomized Controlled Trial (RCT): Remote SBIRT Vs. In-Person SBIRT
Medical University of South Carolina
NCT04630249
Risk Reduction Intervention for Vulnerable Young Adult Males
Hunter College of City University of New York
NCT01118416
Building Recovery By Improving Goals, Habits, and Thoughts
RAND
NCT01191788
Prevention of OUD: The HOME Project (Housing, Opportunities, Motivation and Engagement)
Ohio State University
NCT04135703
Concurrent Treatment of Substance Abuse and Child Maltreatment
University of South Carolina
NCT02774525
Mental Health, Gender-Based Violence, and Stunting in Tanzania
Colorado State University
NCT06065293
Leveraging Evidence to Activate Parents
Oregon Social Learning Center
NCT04779229
Adolescents With Substance Use Disorders Transitioníng From Residential Treatment to the Community
Brown University
NCT03592186
Project Uplift: Substance Use and Mental Health Treatment for Young Sexual and Gender Minorities
Duke University
NCT04546061
Examining Community-based Effectiveness of a Substance Use and HIV Risk Reduction Intervention for Young Men of Color
Hunter College of City University of New York
NCT03488914
Feasibility and Efficacy of a Brief Mindfulness-Based Intervention SMOKING INTERVENTION VIA THE INTERNET
Wayne State University
NCT04572126
American Indian and Alaska Native Men Who Have Sex With Men HIV & Substance Abuse Research
University of Washington
NCT03049904
A Library-based Prevention Intervention for Adolescents Affected by Parental Drug Use
Johns Hopkins Bloomberg School of Public Health
NCT05033821
Pilot Test of a Cultural Intervention to Enhance Alaska Native Students' Behavioral Health
University of Alaska Anchorage
NCT04561544
A Substance Use Adaptation of Fathering Through Change
University of Oregon
NCT04532619
NOLA GEM: Feasibility and Acceptability of an MHealth Intervention for Violence-affected PLWH
Tulane University
NCT05784714
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
Mindfulness for at Risk Youth: Understanding Substance Use and Important Mechanisms of Change
University of Southern California
NCT04160754
Home Visitation Enhancing Linkages Project
The National Center on Addiction and Substance Abuse at Columbia University
NCT03750487
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 3 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance Use records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance Use trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance Use page
89 registered trials, 42 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 42 Substance Use trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins Bloomberg School of Public Health sponsors the most Substance Use trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins Bloomberg School of Public Health's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance Use condition card totals 89 registered trials; most-linked intervention Treatment as Usual; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.