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NCT06274021 · ClinicalTrials.gov registry record · Early Phase 1
Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
A Early Phase 1 study of Spinal Cord Injuries and Spinal Cord Injury, sponsored by University of Mississippi Medical Center.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 16
- Enrollment target
- 2
- Study locations
NCT06274021: Recruiting Early Phase 1 study of Spinal Cord Injuries and Spinal Cord Injury, sponsored by University of Mississippi Medical Center.
NCT06274021 is a Early Phase 1 study of Spinal Cord Injuries and Spinal Cord Injury that is actively recruiting participants, run by University of Mississippi Medical Center. The registered enrollment target is 16 participants, below the 62-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (74% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06274021, a Early Phase 1 study of Spinal Cord Injuries and Spinal Cord Injury, is actively recruiting participants, sponsored by University of Mississippi Medical Center.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 16 participants
- Enrollment target
- 2
- Study locations
Study Summary
People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical currents using skin electrodes over the lower back and belly. The investigators want to see how well the intervention of transcutaneous spinal stimulation performs by testing different levels of stimulation pulse rates. Also, transcutaneous spinal stimulation is compared to muscle relaxants such as baclofen and tizanidine, commonly given to people with spinal cord injuries, to reduce muscle stiffness and spasms. By doing this, the investigators hope to discover if transcutaneous spinal stimulation similarly reduces muscle spasms and stiffness or if combining both methods works best. This could help improve treatment options for people with spinal cord injuries in the future.
Conditions Studied
Interventions
- DEVICE Transcutaneous spinal stimulation at 100 Hz
- DEVICE Transcutaneous spinal stimulation at 50 Hz
- COMBINATION_PRODUCT Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen
- COMBINATION_PRODUCT Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine
- DEVICE Sham transcutaneous spinal stimulation
Study Locations (2)
Mississippi
- Methodist Rehabilitation Center - Jackson
- University of Mississippi Medical Center - Jackson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2024-03-01 |
| Est. Completion | 2025-12-31 |
| Phase | Early Phase 1 |
What NCT06274021 shows while recruiting
NCT06274021 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 62-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (74% lower).
The record links to 4 conditions, with Spinal Cord Injuries appearing as the primary indexed condition, and to 5 interventions - of which Transcutaneous spinal stimulation at 100 Hz is the first listed.
NCT06274021 reports a single indexed study location in Mississippi.
Frequently Asked Questions
What is clinical trial NCT06274021 about?
NCT06274021 is a clinical study titled "Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury". People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical curren...
What is the current status of trial NCT06274021?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 16 participants. The study started on 2024-03-01. Estimated completion is 2025-12-31.
What conditions does trial NCT06274021 study?
This clinical trial studies the following conditions: Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic.
What interventions are being tested in trial NCT06274021?
The interventions under investigation include: Transcutaneous spinal stimulation at 100 Hz (DEVICE), Transcutaneous spinal stimulation at 50 Hz (DEVICE), Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen (COMBINATION_PRODUCT), Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine (COMBINATION_PRODUCT), Sham transcutaneous spinal stimulation (DEVICE).
Who is sponsoring clinical trial NCT06274021?
This trial is sponsored by University of Mississippi Medical Center, which has 96 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06274021 being conducted?
This trial has 2 study locations across Mississippi. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06274021's enrollment target sits among peer trials
16 145th of 202 higher than 53 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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