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RECRUITING Early Phase 1

Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury

NCT06274021 · View on ClinicalTrials.gov ↗

Study Summary

People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical currents using skin electrodes over the lower back and belly. The investigators want to see how well the intervention of transcutaneous spinal stimulation performs by testing different levels of stimulation pulse rates. Also, transcutaneous spinal stimulation is compared to muscle relaxants such as baclofen and tizanidine, commonly given to people with spinal cord injuries, to reduce muscle stiffness and spasms. By doing this, the investigators hope to discover if transcutaneous spinal stimulation similarly reduces muscle spasms and stiffness or if combining both methods works best. This could help improve treatment options for people with spinal cord injuries in the future.

Interventions

  • DEVICE Transcutaneous spinal stimulation at 100 Hz
  • DEVICE Transcutaneous spinal stimulation at 50 Hz
  • COMBINATION_PRODUCT Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen
  • COMBINATION_PRODUCT Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine
  • DEVICE Sham transcutaneous spinal stimulation

Study Locations (2)

Mississippi

  • Methodist Rehabilitation Center — Jackson
  • University of Mississippi Medical Center — Jackson

Trial Details

FieldValue
Enrollment Target 16 participants
Start Date 2024-03-01
Est. Completion 2025-12-31
Phase Early Phase 1

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06274021

The ClinicalTrials.gov registry entry for NCT06274021 describes a study currently listed as recruiting. It is categorized as Early Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 16 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Mississippi Medical Center, which has 56 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Spinal Cord Injuries appearing as the primary indexed condition, and to 5 interventions — of which Transcutaneous spinal stimulation at 100 Hz is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06274021 reports 2 study locations spanning 1 distinct geographic area — top geographies include Mississippi. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06274021 about?

NCT06274021 is a clinical study titled "Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury". People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical curren...

What is the current status of trial NCT06274021?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 16 participants. The study started on 2024-03-01. Estimated completion is 2025-12-31.

What conditions does trial NCT06274021 study?

This clinical trial studies the following conditions: Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06274021?

The interventions under investigation include: Transcutaneous spinal stimulation at 100 Hz (DEVICE), Transcutaneous spinal stimulation at 50 Hz (DEVICE), Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen (COMBINATION_PRODUCT), Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine (COMBINATION_PRODUCT), Sham transcutaneous spinal stimulation (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06274021?

This trial is sponsored by University of Mississippi Medical Center, which has 56 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06274021 being conducted?

This trial has 2 study locations across Mississippi. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial