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The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study
NCT06839300 · View on ClinicalTrials.gov ↗
Study Summary
To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.
Conditions Studied
Study Locations (8)
Other
- Charité Berlin — Berlin
- Sri Balaji Action Medical Institute — New Delhi
- King's College Hospital — London
Wisconsin
- Medical College of Wisconsin — Milwaukee
Randwick NSW
- Prince of Wales Hospital — Sydney
Paraná
- Cajuru University Hospital — Curitiba
Vitacura
- Clinica Alemana de Santiago — Santiago
Otahuhu
- MIddlemore Hospital — Auckland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 260 participants |
| Start Date | 2026-02-09 |
| Est. Completion | 2029-12-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06839300
The ClinicalTrials.gov registry entry for NCT06839300 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 260 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AO Foundation, AO Spine, which has 33 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Spinal Cord Injury appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06839300 reports 8 study locations spanning 6 distinct geographic areas — top geographies include Other, Wisconsin, Randwick NSW. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06839300 about?
NCT06839300 is a clinical study titled "The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study". To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer trau...
What is the current status of trial NCT06839300?
This trial is currently recruiting. The enrollment target is 260 participants. The study started on 2026-02-09. Estimated completion is 2029-12-01.
What conditions does trial NCT06839300 study?
This clinical trial studies the following conditions: Spinal Cord Injury. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT06839300?
This trial is sponsored by AO Foundation, AO Spine, which has 33 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06839300 being conducted?
This trial has 8 study locations across Wisconsin, Randwick NSW, Paraná, Vitacura, Otahuhu. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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