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NCT06839300 · ClinicalTrials.gov registry record
The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study
A clinical trial of Spinal Cord Injury, sponsored by AO Foundation, AO Spine.
- Recruiting
- Registry status
- 260
- Enrollment target
- 8
- Study locations
NCT06839300: Recruiting study of Spinal Cord Injury, sponsored by AO Foundation, AO Spine.
NCT06839300 is a study of Spinal Cord Injury that is actively recruiting participants, run by AO Foundation, AO Spine. The registered enrollment target is 260 participants, above the 84-participant average among 99 other Spinal Cord Injury trials with a reported enrollment target (210% higher). The trial reports 8 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06839300, a study of Spinal Cord Injury, is actively recruiting participants, sponsored by AO Foundation, AO Spine.
- RECRUITING
- Registry status
- 260 participants
- Enrollment target
- 8
- Study locations
Study Summary
To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.
Primary Outcome
To determine the accuracy of serum NF-L and GFAP levels (ie, the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D). The primary time points of the serum biomarker levels to be investigated are Day 1, Day 2, Day 3, and Day 4 postinjury (section 5.2). Secondary time points to be explored are Day 5, Day 6, and Day 7 postinjury. These assessment time
Conditions Studied
Study Locations (8)
Other
- Charité Berlin - Berlin
- Sri Balaji Action Medical Institute - New Delhi
- King's College Hospital - London
Wisconsin
- Medical College of Wisconsin - Milwaukee
Randwick NSW
- Prince of Wales Hospital - Sydney
Paraná
- Cajuru University Hospital - Curitiba
Vitacura
- Clinica Alemana de Santiago - Santiago
Otahuhu
- MIddlemore Hospital - Auckland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 260 participants |
| Start Date | 2026-02-09 |
| Est. Completion | 2029-12-01 |
What NCT06839300 shows while recruiting
NCT06839300 is an observational study that tracks outcomes without assigning an intervention. The registered 260 participants enrollment target is mid-sized for trials with a published cap, above the 84-participant average among 99 other Spinal Cord Injury trials with a reported enrollment target (210% higher).
The record links to 1 condition, with Spinal Cord Injury appearing as the primary indexed condition, and to 0 interventions.
NCT06839300 lists 8 locations in 6 states (Other, Wisconsin, Randwick NSW).
Frequently Asked Questions
What is clinical trial NCT06839300 about?
NCT06839300 is a clinical study titled "The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study". To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer trau...
What is the current status of trial NCT06839300?
This trial is currently recruiting. The enrollment target is 260 participants. The study started on 2026-02-09. Estimated completion is 2029-12-01.
What conditions does trial NCT06839300 study?
This clinical trial studies the following conditions: Spinal Cord Injury.
Who is sponsoring clinical trial NCT06839300?
This trial is sponsored by AO Foundation, AO Spine, which has 9 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06839300 being conducted?
This trial has 8 study locations across Wisconsin, Randwick NSW, Paraná, Vitacura, Otahuhu. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06839300's enrollment target sits among peer trials
260 5th of 99 higher than 95 of 99 other Spinal Cord Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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