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NCT06989905 · ClinicalTrials.gov registry record · Early Phase 1
MEP Up-conditioning to Target Corticospinal Plasticity
A Early Phase 1 study of Spinal Cord Injury and Tetraplegia/Tetraparesis, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 11
- Enrollment target
- 1
- Study location
NCT06989905: Recruiting Early Phase 1 study of Spinal Cord Injury and Tetraplegia/Tetraparesis, sponsored by Medical University of South Carolina.
NCT06989905 is a Early Phase 1 study of Spinal Cord Injury and Tetraplegia/Tetraparesis that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 11 participants, below the 86-participant average among 99 other Spinal Cord Injury trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06989905, a Early Phase 1 study of Spinal Cord Injury and Tetraplegia/Tetraparesis, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 11 participants
- Enrollment target
- 1
- Study location
Study Summary
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand. Also, brain and spine magnetic resonance imaging will be collected before and after the training. The imaging measurements will tell investigators about how spinal damage, brain function, and brain structure relate to motor presentation and the response to the training.
Primary Outcome
Size of MEP elicited at the fixed stimulus intensity (e.g., \~ 10-15% maximum stimulator output) of transcranial magnetic stimulation (TMS) above motor threshold) (in %M wave maximum amplitude)
Conditions Studied
Interventions
- BEHAVIORAL Up-conditioning of the wrist extensor motor evoked potential
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2025-05-27 |
| Est. Completion | 2027-03-31 |
| Phase | Early Phase 1 |
What NCT06989905 shows while recruiting
NCT06989905 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 86-participant average among 99 other Spinal Cord Injury trials with a reported enrollment target (87% lower).
The record links to 2 conditions, with Spinal Cord Injury appearing as the primary indexed condition, and to 1 intervention - of which Up-conditioning of the wrist extensor motor evoked potential is the first listed.
NCT06989905 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT06989905 about?
NCT06989905 is a clinical study titled "MEP Up-conditioning to Target Corticospinal Plasticity". Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation trai...
What is the current status of trial NCT06989905?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 11 participants. The study started on 2025-05-27. Estimated completion is 2027-03-31.
What conditions does trial NCT06989905 study?
This clinical trial studies the following conditions: Spinal Cord Injury, Tetraplegia/Tetraparesis.
What interventions are being tested in trial NCT06989905?
The interventions under investigation include: Up-conditioning of the wrist extensor motor evoked potential (BEHAVIORAL).
Who is sponsoring clinical trial NCT06989905?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06989905 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06989905's enrollment target sits among peer trials
11 80th of 99 higher than 19 of 99 other Spinal Cord Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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