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ClinicalTrials.gov 36 recruiting now official registry

Small Lymphocytic Lymphoma clinical trials

36 of 82 indexed Small Lymphocytic Lymphoma trials are currently recruiting.

82 US clinical trials · 36 currently recruiting

Small Lymphocytic Lymphoma is the subject of 82 registered US clinical trials on ClinicalTrials.gov, 36 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 62 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 6 of these trials.

The research picture

Small Lymphocytic Lymphoma has 82 registered US clinical trials, 36 of them open to new participants right now, about 44% of the total.

36
recruiting participants now
44%
of trials open to enrollment
16
in Phase 3–4 (later-stage)
6
top sponsor: National Cancer Institute (NCI)
Phase 124Phase 238Phase 316

Active & Recent Trials

82 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 120 participants

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Cellectar Biosciences

NCT02952508

ACTIVE NOT RECRUITING Phase 2 81 participants

Ibrutinib, Fludarabine Phosphate, Cyclophosphamide, and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT02629809

ACTIVE NOT RECRUITING Phase 2 72 participants

Pirtobrutinib and Venetoclax With MRD Detection for Previously Untreated Chronic Lymphocytic Leukemia

Mayo Clinic

NCT05677919

ACTIVE NOT RECRUITING Phase 2 55 participants

A Study on Limiting Treatment Time With Acalabrutinib Combined With Obinutuzumab in People With CLL or SLL

Memorial Sloan Kettering Cancer Center

NCT04722172

ACTIVE NOT RECRUITING Phase 2 50 participants

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

M.D. Anderson Cancer Center

NCT02846623

ACTIVE NOT RECRUITING Phase 2 49 participants

Lenalidomide and Vaccine Therapy in Treating Patients With Early-Stage Asymptomatic Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

National Cancer Institute (NCI)

NCT01351896

ACTIVE NOT RECRUITING Phase 2 42 participants

Ibrutinib as an Immune Modulating Agent for Patients With Asymptomatic, High-risk CLL/SLL Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Jennifer Woyach

NCT02518555

ACTIVE NOT RECRUITING Phase 1 40 participants

Safe Accelerated Venetoclax Escalation in CLL

Dana-Farber Cancer Institute

NCT04843904

ACTIVE NOT RECRUITING Phase 2 33 participants

Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

University of Washington

NCT02339922

ACTIVE NOT RECRUITING Phase 2 29 participants

A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL

National Heart, Lung, and Blood Institute (NHLBI)

NCT02514083

ACTIVE NOT RECRUITING Phase 2 29 participants

Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL

Jennifer R. Brown, MD, PhD

NCT04624633

ACTIVE NOT RECRUITING Phase 2 26 participants

Tafasitamab and Zanubrutinib for the Treatment of Patients With Newly Diagnosed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, TaZA CLL Study

City of Hope Medical Center

NCT05718869

ACTIVE NOT RECRUITING Phase 1 24 participants

Venetoclax With High-dose Ibrutinib for CLL Progressing on Single Agent Ibrutinib

Michael Choi

NCT03422393

ACTIVE NOT RECRUITING Phase 1 4 participants

A Study Assessing Adverse Event and How Oral ABBV-453 Moves Through the Body in Adult Participants With Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

AbbVie

NCT06291220

COMPLETED Phase 3 652 participants

A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia

BeiGene

NCT03734016

COMPLETED Phase 3 391 participants

A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

Pharmacyclics

NCT01578707

COMPLETED Phase 2 279 participants

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

National Heart, Lung, and Blood Institute (NHLBI)

NCT02208037

COMPLETED Phase 2 125 participants

Efficacy and Safety Study of Idelalisib in Participants With Indolent B-Cell Non-Hodgkin Lymphomas

Gilead Sciences

NCT01282424

COMPLETED Phase 2 77 participants

Ofatumumab for Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

SCRI Development Innovations

NCT01113632

COMPLETED Phase 1 50 participants

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

Massachusetts General Hospital

NCT00644189

COMPLETED Phase 2 50 participants

Phase II Safety and Efficacy Study of Single-agent AT-101 in Patients With Relapsed or Refractory B-cell Malignancies

Ascenta Therapeutics

NCT00275431

COMPLETED Phase 1 49 participants

A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

AbbVie

NCT01682616

COMPLETED Phase 2 41 participants

Arsenic Trioxide in Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

SCRI Development Innovations

NCT00193518

COMPLETED Phase 1 36 participants

Etanercept and Rituximab in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

John Byrd

NCT00201682

COMPLETED Phase 2 34 participants

Study of Bendamustine/Rituxan Induction Chemotherapy With Revlimid Maintenance for Relapsed/Refractory CLL and SLL

University of Wisconsin, Madison

NCT00974233

COMPLETED Phase 2 24 participants

Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi

MorphoSys

NCT02639910

COMPLETED Phase 2 22 participants

Imexon for Relapsed Follicular and Aggressive Lymphomas

University of Rochester

NCT01314014

COMPLETED Phase 1 16 participants

Phase 1 Study of TG02 Citrate in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

Tragara Pharmaceuticals

NCT01699152

COMPLETED Phase 2 16 participants

Perifosine in Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Daphne Friedman

NCT00873457

COMPLETED Phase 1 16 participants

Pharmacodynamic (PD) Study of Intranodal Adenovirus-CD154 (Ad-ISF35) in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

University of California, San Diego

NCT00850057

COMPLETED Phase 1 11 participants

Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma

Mayo Clinic

NCT03035331

COMPLETED Phase 1 7 participants

Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma

David Bond, MD

NCT03892044

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 38
Phase 3 16

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Small Lymphocytic Lymphoma Trial Landscape

82 indexed Small Lymphocytic Lymphoma studies · 36 recruiting (44%).

Phase mix: 16 late (III/IV) vs 62 early (I/II).

Top sponsor: National Cancer Institute (NCI) (6 trials), 9 others listed. 32 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Small Lymphocytic Lymphoma?

PlainTrial tracks 82 US clinical trials for Small Lymphocytic Lymphoma, of which 36 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Small Lymphocytic Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.