Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05910762 · ClinicalTrials.gov registry record · NA
Human Learning of New Structured Information Across Time and Sleep
A NA study of Sleep and Learning, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- NA
- Development phase
- 105
- Enrollment target
- 1
- Study location
NCT05910762: Recruiting NA study of Sleep and Learning, sponsored by University of Pennsylvania.
NCT05910762 is a NA study of Sleep and Learning that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 105 participants, below the 4,165-participant average among 151 other Sleep trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05910762, a NA study of Sleep and Learning, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- NA
- Development phase
- 105 participants
- Enrollment target
- 1
- Study location
Study Summary
Acting adaptively requires quickly picking up on structure in the environment and storing the acquired knowledge for effective future use. Dominant theories of the hippocampus have focused on its ability to encode individual snapshots of experience, but the investigators and others have found evidence that it is also crucial for finding structure across experiences. The mechanisms of this essential form of learning have not been established. The investigators have developed a neural network model of the hippocampus instantiating the theory that one of its subfields can quickly encode structure using distributed representations, a powerful form of representation in which populations of neurons become responsive to multiple related features of the environment. The first aim of this project is to test predictions of this model using high resolution functional magnetic resonance imaging (fMRI) in paradigms requiring integration of information across experiences. The results will clarify fundamental mechanisms of how humans learn novel structure, adjudicating between existing models of this process, and informing further model development. There are also competing theories as to the eventual fate of new hippocampal representations. One view posits that during sleep, the hippocampus replays recent information to build longer-term distributed representations in neocortex. Another view claims that memories are directly and independently formed and consolidated within the hippocampus and neocortex. The second aim of this project is to test between these theories. The investigators will assess changes in hippocampal and cortical representations over time by re-scanning participants and tracking changes in memory at a one-week delay. Any observed changes in the brain and behavior across time, however, may be due to generic effects of time or to active processing during sleep. The third aim is thus to assess the specific causal contributions of sleep to the consolidation of
Primary Outcome
Changes in spatial correlations between the MRI BOLD pattern associated with related objects over the course of learning and across the one-week delay.
Conditions Studied
Interventions
- BEHAVIORAL Associative inference
- BEHAVIORAL Category learning
- BEHAVIORAL Sleep
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2023-06-05 |
| Est. Completion | 2028-03 |
| Phase | NA |
What NCT05910762 shows while recruiting
NCT05910762 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, below the 4,165-participant average among 151 other Sleep trials with a reported enrollment target (97% lower).
The record links to 4 conditions, with Sleep appearing as the primary indexed condition, and to 3 interventions - of which Associative inference is the first listed.
NCT05910762 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05910762 about?
NCT05910762 is a clinical study titled "Human Learning of New Structured Information Across Time and Sleep". Acting adaptively requires quickly picking up on structure in the environment and storing the acquired knowledge for effective future use. Dominant theories of the hippocampus have focused on its ability to encode individual snapshots of experience, but the investigators and others have found eviden...
What is the current status of trial NCT05910762?
This trial is currently recruiting. It is a NA study. The enrollment target is 105 participants. The study started on 2023-06-05. Estimated completion is 2028-03.
What conditions does trial NCT05910762 study?
This clinical trial studies the following conditions: Sleep, Learning, Consolidation, Humans.
What interventions are being tested in trial NCT05910762?
The interventions under investigation include: Associative inference (BEHAVIORAL), Category learning (BEHAVIORAL), Sleep (BEHAVIORAL).
Who is sponsoring clinical trial NCT05910762?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05910762 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sleep
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05910762's enrollment target sits among peer trials
105 56th of 151 higher than 95 of 151 other Sleep trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sleep trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Student Exercise and Sleep Timing Study - Part 2
RECRUITING · NA
-
The Effects of Sleep on Human Microbiota: Implications for Health and Disease
RECRUITING · NA
-
The Goodnight Screen Media Study
RECRUITING · NA
-
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
RECRUITING · NA
-
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
RECRUITING · NA
-
Shifting Sleep Timing in Teens
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03372317 · 105 participants
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
- NCT04253964 · 105 participants · Phase 2
Pilot Study of Performance Status 2 vs. Performance Status 0-1 Non-small Cell Lung Cancer Patients Treated With Chemo/Immunotherapy
- NCT04742452 · 105 participants · NA
Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears
- NCT04875429 · 105 participants · NA
Zenith® Fenestrated+ Clinical Study
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI