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NCT05336084 · ClinicalTrials.gov registry record · NA
Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
A NA study of Sleep, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 96
- Enrollment target
- 1
- Study location
NCT05336084: Recruiting NA study of Sleep, sponsored by University of Pittsburgh.
NCT05336084 is a NA study of Sleep that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 96 participants, below the 4,165-participant average among 151 other Sleep trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05336084, a NA study of Sleep, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 96 participants
- Enrollment target
- 1
- Study location
Study Summary
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times, which may increase the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to modify these disruptions is unknown. Project 1 (P1), specifically examines homeostatic and circadian characteristics as mechanisms linking habitual sleep patterns, reward and cognitive control (at subjective, behavioral, and circuit levels), and longitudinal substance use risk.
Primary Outcome
Change in the slope of EEG delta power (0.5 - 4 Hz) across NREM periods (frontal leads) on the night preceding vs. following the 36-h ultradian sleep/wake protocol (as measured by polysomnography). This procedure is no longer being collected as of January 2026.
Conditions Studied
Interventions
- BEHAVIORAL Ultradian sleep/wake protocol
Study Locations (1)
Pennsylvania
- Western Psychiatric Hospital - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2022-03-04 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT05336084 shows while recruiting
NCT05336084 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 96 participants, a relatively small participant target, below the 4,165-participant average among 151 other Sleep trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Sleep appearing as the primary indexed condition, and to 1 intervention - of which Ultradian sleep/wake protocol is the first listed.
NCT05336084 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05336084 about?
NCT05336084 is a clinical study titled "Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents". Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times, which may increa...
What is the current status of trial NCT05336084?
This trial is currently recruiting. It is a NA study. The enrollment target is 96 participants. The study started on 2022-03-04. Estimated completion is 2026-06-30.
What conditions does trial NCT05336084 study?
This clinical trial studies the following conditions: Sleep.
What interventions are being tested in trial NCT05336084?
The interventions under investigation include: Ultradian sleep/wake protocol (BEHAVIORAL).
Who is sponsoring clinical trial NCT05336084?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05336084 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sleep
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05336084's enrollment target sits among peer trials
96 70th of 151 higher than 81 of 151 other Sleep trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sleep trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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