Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Single-ventricle: early-phase trial registry
12 of 18 indexed Single-ventricle trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #953 of 28,707 conditions by registered trial count.
18 US clinical trials · 12 currently recruiting · #953 of 28,707 conditions by registered trial count
Single-ventricle: 18 US clinical trials tracked, 12 recruiting.
Single-ventricle is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Boston Children's Hospital, running 5 of these trials.
Enrollment posture brief
Registry condition single-ventricle
OPEN 12 | RECR 67% | LATE 0 | EARLY 3 | RANK #953 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Acute Hypoxemic Respiratory Failure (67% recruiting · 6 trials)
Single-ventricle lists 12 open slots (67% of 18 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Single-ventricle on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Single-ventricle is recruiting above its size-band peers.
12 of 18 indexed trials (66.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Single-ventricle research.
Boston Children's Hospital accounts for 5 of 18 trials (27.8%). 11 distinct sponsors appear on at least one study for this condition label.
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Most Single-ventricle trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 18 trials that report a genuine target (sentinel values excluded). 12 of those (66.7%) plan for fewer than 100 participants.
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Single-ventricle splits between interventional and observational designs.
10 interventional and 8 observational studies make up this index (55.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
18 total, page 1 of 1
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
Leiden University Medical Center
NCT06932081
Fontan Fitness Trial
Children's Hospital of Philadelphia
NCT06918795
Re-Energize Fontan
Stanford University
NCT04195451
Fibrosis and the Fontan
Children's Hospital of Philadelphia
NCT04901975
Ventripoint Single Ventricle Study
Duke University
NCT05262907
REHAB Fontan Failure: A Trial of Cardiac Rehabilitation
Stanford University
NCT06150950
ET1 Concentration, Metabolic Pathway Activation, and Pulmonary Blood Flow in Infants Undergoing Superior Cavo-Pulmonary Anastomosis
University of Colorado, Denver
NCT03404258
Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts
Nationwide Children's Hospital
NCT04467671
Transcatheter Fontan Stenting: Impact on Hepatic Stiffness and Exercise Capacity
Children's Hospital Los Angeles
NCT07073612
Association of Near Infrared Spectroscopy With Interstage Outcomes
Advocate Hospital System
NCT06538571
PK/PD of Digoxin in Infants With SVHD
Duke University
NCT06613477
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
Boston Children's Hospital
NCT06434207
Clinical Characteristics and Associations of the "Good Fontan" Patient
Boston Children's Hospital
NCT03470428
Frailty in Children With Cardiac Disease
Children's Mercy Hospital Kansas City
NCT02999438
Single Ventricle Outcome
Emory University
NCT00308217
Enhanced External Counterpulsation in Patients With Fontan Circulation
Boston Children's Hospital
NCT04956952
The Effect of Fontan Fenestration Closure on Hepatic Stiffness
Boston Children's Hospital
NCT03481985
Improving Functional Capacity in Fontan Patients Through Inspiratory Muscle Training
Boston Children's Hospital
NCT01977222
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Single-ventricle records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Single-ventricle trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Single-ventricle page
18 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 12 Single-ventricle trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Boston Children's Hospital sponsors the most Single-ventricle trials on record, review their full trial history before evaluating a specific study. See Boston Children's Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Single-ventricle condition card totals 18 registered trials; most-linked intervention Actigraph to check activity levels at home; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.