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ClinicalTrials.gov 7 recruiting now early-phase tilt small index

Retinoblastoma: early-phase trial registry

7 of 16 indexed Retinoblastoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,060 of 28,707 conditions by registered trial count.

16 US clinical trials · 7 currently recruiting · #1,060 of 28,707 conditions by registered trial count

Retinoblastoma: 16 US clinical trials tracked, 7 recruiting.

Retinoblastoma is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 4 of these trials.

Enrollment posture brief

Registry condition retinoblastoma

OPEN 7 | RECR 44% | LATE 0 | EARLY 10 | RANK #1060 | SPON 4

Nearest open-share peer: Acute Respiratory Distress Syndrome (44% recruiting · 32 trials)

Adolescent62.5%Alcohol Intoxication56.3%Retinoblastoma (this)44%AL Amyloidosis43.8%Allergy18.8%
Open-enrollment share among volume-matched conditions near Retinoblastoma

Retinoblastoma lists 7 open slots (44% of 16 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Retinoblastoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Retinoblastoma is recruiting below its size-band peers.

    7 of 16 indexed trials (43.8%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Retinoblastoma research.

    Memorial Sloan Kettering Cancer Center accounts for 4 of 16 trials (25%). 12 distinct sponsors appear on at least one study for this condition label.

  3. Most Retinoblastoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 68 among the 16 trials that report a genuine target (sentinel values excluded). 10 of those (62.5%) plan for fewer than 100 participants.

  4. Retinoblastoma splits between interventional and observational designs.

    10 interventional and 6 observational studies make up this index (62.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 25

Open and recent trials

16 total, page 1 of 1

RECRUITING 6,035 participants

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

National Cancer Institute (NCI)

NCT01109394

RECRUITING 900 participants

Studying Health Outcomes After Treatment in Patients With Retinoblastoma

Vanderbilt-Ingram Cancer Center

NCT03932786

RECRUITING 800 participants

RB Liquid Biopsy Biorepository

Children's Hospital Los Angeles

NCT04959097

RECRUITING 100 participants

Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.

University of Washington

NCT06725173

RECRUITING 75 participants

Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients

Memorial Sloan Kettering Cancer Center

NCT03546387

RECRUITING Phase 1 45 participants

GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

Stephan Grupp MD PhD

NCT05650749

RECRUITING Phase 2 30 participants

Retinoblastoma Phase II Expanded Access Clinical Trial

Targeted Therapy Technologies

NCT06679634

ACTIVE NOT RECRUITING 473 participants

Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life

Memorial Sloan Kettering Cancer Center

NCT00639301

ACTIVE NOT RECRUITING Phase 2 174 participants

Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

St. Jude Children's Research Hospital

NCT01783535

ACTIVE NOT RECRUITING Phase 1 68 participants

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

NCT04483778

ACTIVE NOT RECRUITING Phase 1 44 participants

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

NCT03618381

COMPLETED Phase 2 50 participants

Chemotherapy in Treating Patients With Retinoblastoma

Memorial Sloan Kettering Cancer Center

NCT00002675

COMPLETED Phase 2 30 participants

Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

Ann & Robert H Lurie Children's Hospital of Chicago

NCT00179920

COMPLETED Phase 1 28 participants

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Pediatric Brain Tumor Consortium

NCT00006246

COMPLETED Phase 2 22 participants

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00024258

COMPLETED Phase 1 18 participants

Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors

Emory University

NCT01331135

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5

Named interventions

Most-linked intervention names on Retinoblastoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

carboplatin Drug
2 trials
Laser hyperthermia Procedure
1 trials
Local Surgery Procedure
1 trials
VP-16 Drug
1 trials
arsenic trioxide Drug
1 trials
busulfan Drug
1 trials
second generation 4-1BBζ EGFR806-EGFRt and a second generation 4 1BBζ CD19-Her2tG Biological
1 trials
second generation 4-1BBζ EGFR806-EGFRt Biological
1 trials

US sites by state

Facility locations filed on Retinoblastoma trials. A trial with sites in several states counts in each.

New York 6 trials
Washington 4 trials
Pennsylvania 3 trials
Texas 2 trials
Tennessee 2 trials
North Carolina 2 trials
Illinois 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Retinoblastoma page

16 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Retinoblastoma condition card totals 16 registered trials; most-linked intervention carboplatin; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.