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NCT06725173 · ClinicalTrials.gov registry record
Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.
A clinical trial of Retinoblastoma and Retinoblastoma Bilateral, sponsored by University of Washington.
- Recruiting
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT06725173: Recruiting study of Retinoblastoma and Retinoblastoma Bilateral, sponsored by University of Washington.
NCT06725173 is a study of Retinoblastoma and Retinoblastoma Bilateral that is actively recruiting participants, run by University of Washington. The registered enrollment target is 100 participants, below the 586-participant average among 15 other Retinoblastoma trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06725173, a study of Retinoblastoma and Retinoblastoma Bilateral, is actively recruiting participants, sponsored by University of Washington.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this observational study is undertake a detailed phenotypic and genotypic study of patients with ocular and secondary cancers due to mutations in the RB1 gene. Our research sequencing approach will allow advanced insight to for further detailed genotypic understanding of parent-of-origin for valuable insight into the genotype-phenotype relationship of this cancer syndrome.
Primary Outcome
Methylation signatures and genomic variant information to determine phase of the pathogenic variants in RB1 to specific differentially methylated signals in RB1
Conditions Studied
Interventions
- GENETIC Targeted Long-read sequencing
Study Locations (1)
Washington
- University of Washington - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2026-03-16 |
| Est. Completion | 2031-01-01 |
What NCT06725173 shows while recruiting
NCT06725173 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 586-participant average among 15 other Retinoblastoma trials with a reported enrollment target (83% lower).
The record links to 5 conditions, with Retinoblastoma appearing as the primary indexed condition, and to 1 intervention - of which Targeted Long-read sequencing is the first listed.
NCT06725173 reports a single indexed study location in Washington.
Frequently Asked Questions
What is clinical trial NCT06725173 about?
NCT06725173 is a clinical study titled "Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.". The goal of this observational study is undertake a detailed phenotypic and genotypic study of patients with ocular and secondary cancers due to mutations in the RB1 gene. Our research sequencing approach will allow advanced insight to for further detailed genotypic understanding of parent-of-origin...
What is the current status of trial NCT06725173?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2026-03-16. Estimated completion is 2031-01-01.
What conditions does trial NCT06725173 study?
This clinical trial studies the following conditions: Retinoblastoma, Retinoblastoma Bilateral, Retinoblastoma Unilateral, Retinoblastoma, Extraocular, Retinoblastoma, Recurrent.
What interventions are being tested in trial NCT06725173?
The interventions under investigation include: Targeted Long-read sequencing (GENETIC).
Who is sponsoring clinical trial NCT06725173?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06725173 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06725173's enrollment target sits among peer trials
100 6th of 15 higher than 10 of 15 other Retinoblastoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Retinoblastoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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