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NCT05650749 · ClinicalTrials.gov registry record · Phase 1
GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma
A Phase 1 study of Retinoblastoma and High-risk Neuroblastoma, sponsored by Stephan Grupp MD PhD.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 45
- Enrollment target
- 1
- Study location
NCT05650749 is a Phase 1 study of Retinoblastoma and High-risk Neuroblastoma that is actively recruiting participants, run by Stephan Grupp MD PhD. The registered enrollment target is 45 participants, below the 590-participant average among 15 other Retinoblastoma trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05650749, a Phase 1 study of Retinoblastoma and High-risk Neuroblastoma, is actively recruiting participants, sponsored by Stephan Grupp MD PhD.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 45 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a first in human dose escalation trial to determine the safety of administering GPC2 CAR T cells in patients with advanced neuroblastoma or retinoblastoma.
Conditions Studied
Interventions
- BIOLOGICAL GPC2 CAR T cells
Study Locations (1)
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2023-05-23 |
| Est. Completion | 2030-01-30 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05650749
The ClinicalTrials.gov registry entry for NCT05650749 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 590-participant average among 15 other Retinoblastoma trials with a reported enrollment target (92% lower). The listed sponsor is Stephan Grupp MD PhD, which has 8 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Retinoblastoma appearing as the primary indexed condition, and to 1 intervention - of which GPC2 CAR T cells is the first listed.
NCT05650749 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05650749 about?
NCT05650749 is a clinical study titled "GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma". This is a first in human dose escalation trial to determine the safety of administering GPC2 CAR T cells in patients with advanced neuroblastoma or retinoblastoma.
What is the current status of trial NCT05650749?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2023-05-23. Estimated completion is 2030-01-30.
What conditions does trial NCT05650749 study?
This clinical trial studies the following conditions: Retinoblastoma, High-risk Neuroblastoma, Refractory Neuroblastoma, Relapsed Neuroblastoma, Metastatic Retinoblastoma.
What interventions are being tested in trial NCT05650749?
The interventions under investigation include: GPC2 CAR T cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT05650749?
This trial is sponsored by Stephan Grupp MD PhD, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05650749 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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