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NCT06171685 · ClinicalTrials.gov registry record · Phase 2
MMRC Horizon One Adaptive Platform Trial Evaluating Therapies in RRMM
A Phase 2 study of Refractory Multiple Myeloma and Relapse Multiple Myeloma, sponsored by Multiple Myeloma Research Consortium.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 300
- Enrollment target
- 13
- Study locations
NCT06171685: Recruiting Phase 2 study of Refractory Multiple Myeloma and Relapse Multiple Myeloma, sponsored by Multiple Myeloma Research Consortium.
NCT06171685 is a Phase 2 study of Refractory Multiple Myeloma and Relapse Multiple Myeloma that is actively recruiting participants, run by Multiple Myeloma Research Consortium. The registered enrollment target is 300 participants, above the 44-participant average among 67 other Refractory Multiple Myeloma trials with a reported enrollment target (582% higher). The trial reports 13 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06171685, a Phase 2 study of Refractory Multiple Myeloma and Relapse Multiple Myeloma, is actively recruiting participants, sponsored by Multiple Myeloma Research Consortium.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 300 participants
- Enrollment target
- 13
- Study locations
Study Summary
This trial is an adaptive platform trial. The structure of the protocol allows the trial to evolve over time. Multiple investigational arms will be included within the trial under a Master Protocol (MP). These investigational arms may be added as appendices at different times depending on whether they are trial-ready and whether accrual in the trial will support another arm. Accrual to an arm will terminate in accord with the arm's appendix to the Master Protocol. The purpose of this proposed structure is to support the recurrent research challenge of efficiently evaluating what is the best therapy for a particular patient.
Primary Outcome
Objective Response Rate
Conditions Studied
Interventions
- DRUG Teclistamab Monotherapy
- DRUG Teclistamab
Study Locations (13)
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
- Dana Farber Cancer Institute/Harvard Medical School - Boston
New York
- Memorial Sloan Kettering Cancer Center - New York
- Mt. Sinai School of Medicine - New York
California
- City of Hope - Duarte
Georgia
- Emory Winship Cancer Center - Atlanta
Illinois
- University of Chicago Cancer Center - Chicago
Michigan
- Barbara Ann Karmanos Cancer Center - Detroit
Minnesota
- Mayo Clinic Rochester - Rochester
Missouri
- Washington University Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2024-11-17 |
| Est. Completion | 2030-07-31 |
| Phase | Phase 2 |
What NCT06171685 shows while recruiting
NCT06171685 is an interventional study that assigns participants to a tested intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, above the 44-participant average among 67 other Refractory Multiple Myeloma trials with a reported enrollment target (582% higher).
The record links to 2 conditions, with Refractory Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions - of which Teclistamab Monotherapy is the first listed.
NCT06171685 lists 13 locations in 11 states (Massachusetts, New York, California).
Frequently Asked Questions
What is clinical trial NCT06171685 about?
NCT06171685 is a clinical study titled "MMRC Horizon One Adaptive Platform Trial Evaluating Therapies in RRMM". This trial is an adaptive platform trial. The structure of the protocol allows the trial to evolve over time. Multiple investigational arms will be included within the trial under a Master Protocol (MP). These investigational arms may be added as appendices at different times depending on whether th...
What is the current status of trial NCT06171685?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 300 participants. The study started on 2024-11-17. Estimated completion is 2030-07-31.
What conditions does trial NCT06171685 study?
This clinical trial studies the following conditions: Refractory Multiple Myeloma, Relapse Multiple Myeloma.
What interventions are being tested in trial NCT06171685?
The interventions under investigation include: Teclistamab Monotherapy (DRUG), Teclistamab (DRUG).
Who is sponsoring clinical trial NCT06171685?
This trial is sponsored by Multiple Myeloma Research Consortium, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06171685 being conducted?
This trial has 13 study locations across California, Georgia, Illinois, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Refractory Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06171685's enrollment target sits among peer trials
300 2nd of 67 the highest of 67 other Refractory Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Refractory Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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