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ClinicalTrials.gov 23 recruiting now official registry

Refractory Multiple Myeloma clinical trials

23 of 68 indexed Refractory Multiple Myeloma trials are currently recruiting.

68 US clinical trials · 23 currently recruiting

Refractory Multiple Myeloma is the subject of 68 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 35 of these trials.

The research picture

Refractory Multiple Myeloma has 68 registered US clinical trials, 23 of them open to new participants right now, about 34% of the total.

23
recruiting participants now
34%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
35
top sponsor: National Cancer Institute (NCI)
Phase 122Phase 241Phase 32

Active & Recent Trials

68 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 20 participants

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)

National Cancer Institute (NCI)

NCT06360575

ACTIVE NOT RECRUITING Phase 2 19 participants

Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)

National Cancer Institute (NCI)

NCT06385483

ACTIVE NOT RECRUITING Phase 2 19 participants

Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)

National Cancer Institute (NCI)

NCT06303167

ACTIVE NOT RECRUITING Phase 1 15 participants

A Study of MCARH109 and MCARH125 in People With Multiple Myeloma

Memorial Sloan Kettering Cancer Center

NCT05431608

ACTIVE NOT RECRUITING Phase 2 10 participants

Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)

National Cancer Institute (NCI)

NCT06390826

ACTIVE NOT RECRUITING Phase 2 9 participants

A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to Daratumumab

Weill Medical College of Cornell University

NCT04302324

ACTIVE NOT RECRUITING Phase 1 5 participants

Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple Myeloma

Thomas Martin, MD

NCT05577000

ACTIVE NOT RECRUITING Phase 2 5 participants

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ALK Genetic Changes (MATCH-Subprotocol F)

National Cancer Institute (NCI)

NCT04439266

ACTIVE NOT RECRUITING Phase 2 4 participants

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)

National Cancer Institute (NCI)

NCT04439253

ACTIVE NOT RECRUITING Phase 2 4 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)

National Cancer Institute (NCI)

NCT04439357

ACTIVE NOT RECRUITING Phase 1 3 participants

Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma

Elvira Umyarova

NCT06203912

COMPLETED Phase 3 130 participants

Melphalan and Amifostine Followed By One or Two Autologous or Syngeneic Stem Cell Transplants and Maintenance Therapy in Treating Patients With Stage II-III Multiple Myeloma

Fred Hutchinson Cancer Center

NCT00217438

COMPLETED Phase 1 60 participants

2-Methoxyestradiol in Treating Patients With Advanced Solid Tumors

National Cancer Institute (NCI)

NCT00028821

COMPLETED Phase 1 50 participants

Sorafenib and Bortezomib in Treating Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT00303797

COMPLETED Phase 2 36 participants

Melphalan, Peripheral Stem Cell Transplantation, and Interleukin-2 Followed by Interferon Alfa in Treating Patients With Advanced Multiple Myeloma

Fred Hutchinson Cancer Center

NCT00006244

COMPLETED Phase 1 16 participants

Reduced-Intensity Conditioning Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma

Fred Hutchinson Cancer Center

NCT00054353

COMPLETED Phase 1 14 participants

Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myeloma

Alliance Foundation Trials

NCT03702725

COMPLETED Phase 1 8 participants

Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment

National Cancer Institute (NCI)

NCT03770260

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Phase Distribution

PhaseTrial count
Phase 1 22
Phase 2 41
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Multiple Myeloma Trial Landscape

68 indexed Refractory Multiple Myeloma studies · 23 recruiting (34%).

Phase mix: 2 late (III/IV) vs 63 early (I/II).

Top sponsor: National Cancer Institute (NCI) (35 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Multiple Myeloma?

PlainTrial tracks 68 US clinical trials for Refractory Multiple Myeloma, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Multiple Myeloma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.