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ClinicalTrials.gov 1 recruiting now official registry

Recurrent Melanoma clinical trials

Every US clinical trial registered for Recurrent Melanoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

25 US clinical trials · 1 currently recruiting

The research picture

Recurrent Melanoma has 25 registered US clinical trials, 1 of them open to new participants right now — about 4% of the total.

1
recruiting participants now
4%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
20
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 39 participants

Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel)

M.D. Anderson Cancer Center

NCT06660420

ACTIVE NOT RECRUITING Phase 3 1,673 participants

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

National Cancer Institute (NCI)

NCT01274338

ACTIVE NOT RECRUITING Phase 3 267 participants

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

National Cancer Institute (NCI)

NCT02224781

ACTIVE NOT RECRUITING Phase 2 245 participants

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01134614

ACTIVE NOT RECRUITING Phase 2 88 participants

Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01708941

ACTIVE NOT RECRUITING Phase 2 72 participants

Dinaciclib in Treating Patients With Stage IV Melanoma

National Cancer Institute (NCI)

NCT00937937

ACTIVE NOT RECRUITING Phase 1 59 participants

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT02298959

ACTIVE NOT RECRUITING Phase 2 43 participants

Talimogene Laherparepvec and Pembrolizumab in Treating Patients With Stage III-IV Melanoma

National Cancer Institute (NCI)

NCT02965716

ACTIVE NOT RECRUITING Phase 1 35 participants

Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

National Cancer Institute (NCI)

NCT01303341

COMPLETED Phase 3 823 participants

Carboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT00110019

COMPLETED Phase 1 140 participants

Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas

National Cancer Institute (NCI)

NCT02304458

COMPLETED Phase 1 96 participants

Everolimus and Vatalanib in Treating Patients With Advanced Solid Tumors

Mayo Clinic

NCT00655655

COMPLETED Phase 1 69 participants

Sorafenib and Temsirolimus in Treating Patients With Metastatic, Recurrent, or Unresectable Melanoma

National Cancer Institute (NCI)

NCT00349206

COMPLETED Phase 2 50 participants

Temozolomide and Thalidomide in Treating Patients With Brain Metastases Secondary to Melanoma

National Cancer Institute (NCI)

NCT00072163

COMPLETED Phase 2 50 participants

Vaccine Plus Interleukin-2 in Treating Patients With Advanced Melanoma

National Cancer Institute (NCI)

NCT00005949

COMPLETED Phase 1 40 participants

Imatinib Mesylate and Bevacizumab in Treating Patients With Advanced Melanoma or Other Advanced Cancers

National Cancer Institute (NCI)

NCT00074308

COMPLETED Phase 2 36 participants

Vaccine Therapy in Treating HLA-A2 Positive Patients With Melanoma

National Cancer Institute (NCI)

NCT00003895

COMPLETED Phase 1 25 participants

Tremelimumab and CP-870,893 in Patients With Metastatic Melanoma

Abramson Cancer Center at Penn Medicine

NCT01103635

COMPLETED Phase 2 25 participants

Individualized Temozolomide in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery

Mayo Clinic

NCT01328535

COMPLETED Phase 1 24 participants

Decitabine in Treating Patients With Advanced Solid Tumors

National Cancer Institute (NCI)

NCT00030615

COMPLETED Phase 1 24 participants

Temsirolimus and Bryostatin 1 in Treating Patients With Unresectable or Metastatic Solid Tumors

National Cancer Institute (NCI)

NCT00112476

COMPLETED Phase 2 20 participants

Adjuvant Radiation Therapy in Treating Patients With Resected Desmoplastic Melanoma

Alliance for Clinical Trials in Oncology

NCT00060333

COMPLETED Phase 2 17 participants

Temsirolimus and Bevacizumab in Treating Patients With Stage III or Stage IV Malignant Melanoma

National Cancer Institute (NCI)

NCT00397982

COMPLETED Phase 1 14 participants

Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Combination With Cisplatin, Vinblastine, and Temozolomide in Treating Patients With Recurrent or Metastatic Melanoma

National Cancer Institute (NCI)

NCT01196416

COMPLETED Phase 2

flt3L With or Without Vaccine Therapy in Treating Patients With Metastatic Melanoma or Renal Cell Cancer

National Cancer Institute (NCI)

NCT00019396

Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 11
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Melanoma Trial Landscape

ClinicalTrials.gov lists 25 US studies indexed under Recurrent Melanoma, and 1 of those are currently open to recruitment — roughly 4% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Recurrent Melanoma shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 22 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Recurrent Melanoma is led by National Cancer Institute (NCI) with 20 indexed trials, alongside 4 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Melanoma?

PlainTrial tracks 25 US clinical trials for Recurrent Melanoma, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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