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NCT04209387 · ClinicalTrials.gov registry record
Novel EEG Coherence Biomarkers for PTSD Assessment
A clinical trial of PTSD, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- 26
- Enrollment target
- 1
- Study location
NCT04209387: Completed study of PTSD, sponsored by VA Office of Research and Development.
NCT04209387 is a study of PTSD that has completed, run by VA Office of Research and Development. The registered enrollment target is 26 participants, below the 302-participant average among 154 other PTSD trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04209387, a study of PTSD, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
Current practice for diagnosing and managing PTSD relies primarily on subjective clinical assessments by clinicians as well as patient self-report. An independent, objective and neuro-physiology based method for directly assessing brain function is not available, but is much needed to improve diagnosis and management of PTSD. To address this critical need, the investigators propose to test a set of novel biomarkers which are based on measures of coherent activity among the regions of cerebral cortex during sleep. In preliminary studies on EEG acquired during sleep from Veterans with PTSD alone as well as other co-morbidities, the investigators have shown that the neuromarkers were highly sensitive/specific to the presence of PTSD, and highly sensitive to the severity of symptoms in PTSD group. The overall goal of this project is to further validate these novel neurophysiology marker in retrospective and prospective studies
Primary Outcome
Coherence describes the degree of electrical activity (EEG) synchrony among brain regions. Coherence is equivalent to correlation coefficient in frequency domain and takes values from 0 (no synchrony) to 1 (perfect synchrony). A detailed description of this method is provided in: Modarres M, Cochran D, Kennedy DN, Frazier JA. Comparison of comprehensive quantitative EEG metrics between typically developing boys and girls in resting state eyes-open and eyes-closed conditions.
Conditions Studied
Interventions
- BEHAVIORAL Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD ( ACT-SS)
Study Locations (1)
Massachusetts
- VA Bedford HealthCare System, Bedford, MA - Bedford
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2021-02-01 |
| Est. Completion | 2024-12-31 |
What the finished NCT04209387 record still lists
NCT04209387 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 302-participant average among 154 other PTSD trials with a reported enrollment target (91% lower).
The record links to 1 condition, with PTSD appearing as the primary indexed condition, and to 1 intervention - of which Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD ( ACT-SS) is the first listed.
NCT04209387 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04209387 about?
NCT04209387 is a clinical study titled "Novel EEG Coherence Biomarkers for PTSD Assessment". Current practice for diagnosing and managing PTSD relies primarily on subjective clinical assessments by clinicians as well as patient self-report. An independent, objective and neuro-physiology based method for directly assessing brain function is not available, but is much needed to improve diagno...
What is the current status of trial NCT04209387?
This trial is currently completed. The enrollment target is 26 participants. The study started on 2021-02-01. Estimated completion is 2024-12-31.
What conditions does trial NCT04209387 study?
This clinical trial studies the following conditions: PTSD.
What interventions are being tested in trial NCT04209387?
The interventions under investigation include: Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD ( ACT-SS) (BEHAVIORAL).
Who is sponsoring clinical trial NCT04209387?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04209387 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04209387's enrollment target sits among peer trials
26 132nd of 154 higher than 22 of 154 other PTSD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PTSD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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