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RECRUITING Phase 3

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

NCT06925737 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan (also called I-DXd or MK-2400) to treat mCRPC. The goal of this study is to learn if people who receive I-DXd live longer overall and live longer without the cancer growing or spreading than people who receive chemotherapy.

Interventions

  • DRUG Docetaxel
  • DRUG Rescue Medication
  • DRUG Prednisone
  • DRUG Ifinatamab deruxtecan

Study Locations (20)

California

  • City of Hope Comprehensive Cancer Center ( Site 0049) — Duarte
  • City of Hope Lennar Foundation Cancer Center ( Site 0059) — Irvine
  • Moores Cancer Center ( Site 0010) — La Jolla
  • Cedars-Sinai Medical Center ( Site 0068) — Los Angeles
  • UCLA Hematology/Oncology - Santa Monica ( Site 0002) — Los Angeles
  • University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0006) — Orange
  • Stanford Cancer Center ( Site 0046) — Palo Alto

Connecticut

  • Yale-New Haven Hospital-Yale Cancer Center ( Site 0050) — New Haven
  • Veterans Affairs Connecticut Healthcare System ( Site 0062) — West Haven

District of Columbia

  • The GW Medical Faculty Associates ( Site 0057) — Washington D.C.
  • Washington DC Veterans Affairs Medical Center ( Site 0056) — Washington D.C.

Georgia

  • Emory University School of Medicine- Grady Campus ( Site 0103) — Atlanta
  • Winship Cancer Institute, Emory University ( Site 0003) — Atlanta

Arizona

  • Mayo Clinic in Arizona - Phoenix ( Site 0044) — Phoenix

Colorado

  • Rocky Mountain Regional Veterans Affairs Medical Center ( Site 0053) — Aurora

Florida

  • Mayo Clinic in Florida-Mayo Clinic Comprehensive Cancer Center ( Site 0077) — Jacksonville

Illinois

  • University of Illinois at Chicago-University of Illinois Cancer Center ( Site 0063) — Chicago

Trial Details

FieldValue
Enrollment Target 1,440 participants
Start Date 2025-05-13
Est. Completion 2031-01-06
Phase Phase 3

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06925737

The ClinicalTrials.gov registry entry for NCT06925737 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,440 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Prostate Cancer appearing as the primary indexed condition, and to 4 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06925737 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Connecticut, District of Columbia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06925737 about?

NCT06925737 is a clinical study titled "A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)". Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan (also called I-DXd or MK-2400) to treat mCRPC. The goal of this study is to learn if people who receive I-DXd live longer ove...

What is the current status of trial NCT06925737?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,440 participants. The study started on 2025-05-13. Estimated completion is 2031-01-06.

What conditions does trial NCT06925737 study?

This clinical trial studies the following conditions: Prostate Cancer, Prostatic Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06925737?

The interventions under investigation include: Docetaxel (DRUG), Rescue Medication (DRUG), Prednisone (DRUG), Ifinatamab deruxtecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06925737?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06925737 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Connecticut, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial