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ACTIVE NOT RECRUITING Phase 1

A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants

NCT05022849 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to determine recommended Phase 2 dose (RP2D) regimen(s) of JNJ-75229414 in Part 1 (Dose Escalation and to determine safety at the RP2D regimen(s) in Part 2 (Dose Expansion).

Conditions Studied

Interventions

  • DRUG JNJ-75229414
  • DRUG Bridging Therapy

Study Locations (8)

New York

  • Icahn School of Medicine at Mount Sinai — New York
  • Columbia University Medical Center — New York

California

  • City of Hope Cancer Center — Duarte

Kentucky

  • Norton Cancer Institute — Louisville

Minnesota

  • University Of Minnesota — Minneapolis

North Carolina

  • Levine Cancer Institute — Charlotte

Pennsylvania

  • University of Pennsylvania — Philadelphia

Utah

  • University of Utah Huntsman Cancer Institute — Salt Lake City

Trial Details

FieldValue
Enrollment Target 15 participants
Start Date 2021-09-28
Est. Completion 2037-10-30
Phase Phase 1

Sponsor

Janssen Research & Development

442 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05022849

The ClinicalTrials.gov registry entry for NCT05022849 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Prostatic Neoplasms appearing as the primary indexed condition, and to 2 interventions — of which JNJ-75229414 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05022849 reports 8 study locations spanning 7 distinct geographic areas — top geographies include New York, California, Kentucky. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05022849 about?

NCT05022849 is a clinical study titled "A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants". The purpose of this study is to determine recommended Phase 2 dose (RP2D) regimen(s) of JNJ-75229414 in Part 1 (Dose Escalation and to determine safety at the RP2D regimen(s) in Part 2 (Dose Expansion).

What is the current status of trial NCT05022849?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2021-09-28. Estimated completion is 2037-10-30.

What conditions does trial NCT05022849 study?

This clinical trial studies the following conditions: Prostatic Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05022849?

The interventions under investigation include: JNJ-75229414 (DRUG), Bridging Therapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05022849?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05022849 being conducted?

This trial has 8 study locations across California, Kentucky, Minnesota, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial