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Primary Progressive Aphasia: early-phase trial registry
10 of 16 indexed Primary Progressive Aphasia trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,060 of 28,707 conditions by registered trial count.
16 US clinical trials · 10 currently recruiting · #1,060 of 28,707 conditions by registered trial count
Primary Progressive Aphasia: 16 US clinical trials tracked, 10 recruiting.
Primary Progressive Aphasia is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is University of Texas at Austin, running 3 of these trials.
Enrollment posture brief
Registry condition primary-progressive-aphasia
OPEN 10 | RECR 63% | LATE 1 | EARLY 3 | RANK #1060 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Advanced Gastroesophageal Junction Adenocarcinoma (63% recruiting · 8 trials)
Primary Progressive Aphasia lists 10 open slots (63% of 16 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Primary Progressive Aphasia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Primary Progressive Aphasia is recruiting above its size-band peers.
10 of 16 indexed trials (62.5%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Primary Progressive Aphasia research.
University of Texas at Austin accounts for 3 of 16 trials (18.8%). 8 distinct sponsors appear on at least one study for this condition label.
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Most Primary Progressive Aphasia trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 16 trials that report a genuine target (sentinel values excluded). 12 of those (75%) plan for fewer than 100 participants.
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Primary Progressive Aphasia research is mostly interventional.
13 interventional and 3 observational studies make up this index (81.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
16 total, page 1 of 1
Language in Primary Progressive Aphasia
Northwestern University
NCT00537004
Communication Bridge 3 Study
University of Chicago
NCT06191198
Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
Johns Hopkins University
NCT05386394
Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
University of Texas at Austin
NCT06511752
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
Johns Hopkins University
NCT03887481
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
University of Texas at Austin
NCT05741853
Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
Mayo Clinic
NCT01818661
The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech
Mayo Clinic
NCT03313011
Enhancing Language Function in Aphasia
University of Arizona
NCT05443633
Enhancing Language Function in Primary Progressive Aphasia
University of Arizona
NCT04920318
Treatment for Speech and Language in Primary Progressive Aphasia
University of Texas at Austin
NCT04881617
Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
The University of Texas at Dallas
NCT05368350
Communication Bridge Pilot Study
University of Chicago
NCT06211374
PPA Tele-Savvy: A Pilot Study of an Online Intervention for Caregivers of Persons Living With PPA
Northwestern University
NCT04412083
Network Modulation in Alzheimer's Disease
Brigham and Women's Hospital
NCT04045990
Florbetaben PET Imaging in PPA
University of Chicago
NCT04720001
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Primary Progressive Aphasia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Primary Progressive Aphasia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Primary Progressive Aphasia page
16 registered trials, 10 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 10 Primary Progressive Aphasia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Texas at Austin sponsors the most Primary Progressive Aphasia trials on record, review their full trial history before evaluating a specific study. See University of Texas at Austin's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Primary Progressive Aphasia condition card totals 16 registered trials; most-linked intervention Lexical Retrieval Training (LRT); top US site state Illinois. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.