Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Primary Lateral Sclerosis clinical trials
Every US clinical trial registered for Primary Lateral Sclerosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
10 US clinical trials · 5 currently recruiting
The research picture
Primary Lateral Sclerosis has 10 registered US clinical trials, 5 of them open to new participants right now — about 50% of the total.
- 5
- recruiting participants now
- 50%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 3
- top sponsor: University of Miami
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Clinical Procedures to Support Research in ALS
University of Miami
NCT03489278
Spastic Paraplegia - Centers of Excellence Research Network
Boston Children's Hospital
NCT06553976
Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
University of Missouri-Columbia
NCT07478172
Digital Assessment of Speech and Fine Motor Control in ALS
Milton S. Hershey Medical Center
NCT06315673
Imaging Biomarkers in ALS
University of Minnesota
NCT02567136
TRIAL READY (Clinical Trial Readiness)
University of Miami
NCT03912987
Phenotype, Genotype and Biomarkers 2
University of Miami
NCT04875416
Screening and Natural History: Primary Lateral Sclerosis and Related Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00015444
Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease
Duke University
NCT00324454
Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01143428
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Primary Lateral Sclerosis Trial Landscape
ClinicalTrials.gov lists 10 US studies indexed under Primary Lateral Sclerosis, and 5 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Primary Lateral Sclerosis shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Primary Lateral Sclerosis is led by University of Miami with 3 indexed trials, alongside 6 other organizations in the top contributor list. The list on this page surfaces up to 10 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Primary Lateral Sclerosis?
PlainTrial tracks 10 US clinical trials for Primary Lateral Sclerosis, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Primary Lateral Sclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.