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NCT03912987 · ClinicalTrials.gov registry record
TRIAL READY (Clinical Trial Readiness)
A clinical trial of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, sponsored by University of Miami.
- Active
- Registry status
- 610
- Enrollment target
- 3
- Study locations
NCT03912987: Active study of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, sponsored by University of Miami.
NCT03912987 is a study of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia that is active but no longer recruiting, run by University of Miami. The registered enrollment target is 610 participants, below the 892-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (32% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03912987, a study of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, is active but no longer recruiting, sponsored by University of Miami.
- ACTIVE NOT RECRUITING
- Registry status
- 610 participants
- Enrollment target
- 3
- Study locations
Study Summary
This study, being conducted under the auspice of the CReATe Consortium, will enroll patients with ALS and related disorders as well as healthy controls, with the goal of facilitating clinical validation of leading biological-fluid based biomarker candidates that may aid therapy development for patients with ALS and related disorders.
Primary Outcome
In a population of patients with ALS and related disorders who would meet typical clinical trial eligibility, this study aims to define the natural history (and variability) of urinary neurotrophin receptor extracellular domain (p75ECD); blood and cerebrospinal fluid (CSF) neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH); and among patients with the C9orf72 hexanucleotide repeat expansion mutation (HREM), CSF and peripheral blood mononuclear cell (PBMC) poly(GP).
Conditions Studied
Study Locations (3)
Florida
- University of Miami - Miami
Kansas
- University of Kansas - Kansas City
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 610 participants |
| Start Date | 2019-01-22 |
| Est. Completion | 2026-06 |
What the registry record for NCT03912987 still lists
NCT03912987 is an observational study that tracks outcomes without assigning an intervention. The registered 610 participants enrollment target is mid-sized for trials with a published cap, below the 892-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (32% lower).
The record links to 5 conditions, with Amyotrophic Lateral Sclerosis appearing as the primary indexed condition, and to 0 interventions.
NCT03912987 reports a single indexed study location in Florida, Kansas, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT03912987 about?
NCT03912987 is a clinical study titled "TRIAL READY (Clinical Trial Readiness)". This study, being conducted under the auspice of the CReATe Consortium, will enroll patients with ALS and related disorders as well as healthy controls, with the goal of facilitating clinical validation of leading biological-fluid based biomarker candidates that may aid therapy development for patie...
What is the current status of trial NCT03912987?
This trial is currently active not recruiting. The enrollment target is 610 participants. The study started on 2019-01-22. Estimated completion is 2026-06.
What conditions does trial NCT03912987 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Primary Lateral Sclerosis, Progressive Muscular Atrophy, ALS-Frontotemporal Dementia.
Who is sponsoring clinical trial NCT03912987?
This trial is sponsored by University of Miami, which has 721 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03912987 being conducted?
This trial has 3 study locations across Florida, Kansas, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Amyotrophic Lateral Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03912987's enrollment target sits among peer trials
610 18th of 102 higher than 85 of 102 other Amyotrophic Lateral Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amyotrophic Lateral Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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