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NCT07478172 · ClinicalTrials.gov registry record · NA
Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
A NA study of Amyotrophic Lateral Sclerosis and Myasthenia Gravis, sponsored by University of Missouri-Columbia.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT07478172: Recruiting NA study of Amyotrophic Lateral Sclerosis and Myasthenia Gravis, sponsored by University of Missouri-Columbia.
NCT07478172 is a NA study of Amyotrophic Lateral Sclerosis and Myasthenia Gravis that is actively recruiting participants, run by University of Missouri-Columbia. The registered enrollment target is 50 participants, below the 897-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07478172, a NA study of Amyotrophic Lateral Sclerosis and Myasthenia Gravis, is actively recruiting participants, sponsored by University of Missouri-Columbia.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD). Due to motor unit impairments, NMD patients often cannot tolerate traditional exercise. WB-EMS bypasses voluntary activation limits by directly stimulating muscle contractions. Up to 50 adults with conditions like ALS, SMA, and MG will undergo 20-minute supervised WB-EMS sessions (1-2 times weekly for 4-8 weeks) using the Katalyst system. Outcomes include neural excitability (TMS), motor unit behavior (EMG, NCS), functional tests (walk, balance, strength), and patient-reported fatigue, pain, and quality of life. Strict safety monitoring and exclusion criteria are in place. This study will provide preliminary data on WB-EMS as a potential exercise modality for NMD.
Primary Outcome
Decomposition electromyography (dEMG) is a measurement of motor unit activity; a surface electrode will be placed over the vastus lateralis in the thigh and participants will be asked to activate that muscle. Participants will take standardized positions, sitting with knee at a 75-degree angle. Participants will perform three 5-second maximal voluntary isometric contractions (MVC); this will be followed by 2 contractions each at 35%, 50% and 70% MVC using a trapezoidal force matching protocol.
Conditions Studied
Interventions
- DEVICE Whole-body Electrical Muscle Stimulation Exercise
Study Locations (1)
Missouri
- NextGen Precision Health Building, Clinical and Translational Science Unit - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2026-03-10 |
| Est. Completion | 2031-01-07 |
| Phase | NA |
What NCT07478172 shows while recruiting
NCT07478172 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 897-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (94% lower).
The record links to 10 conditions, with Amyotrophic Lateral Sclerosis appearing as the primary indexed condition, and to 1 intervention - of which Whole-body Electrical Muscle Stimulation Exercise is the first listed.
NCT07478172 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT07478172 about?
NCT07478172 is a clinical study titled "Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease". This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD). Due to motor unit impairments, NMD patients often cannot tolerate traditional exercise. WB-EMS bypasses v...
What is the current status of trial NCT07478172?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2026-03-10. Estimated completion is 2031-01-07.
What conditions does trial NCT07478172 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis, Myasthenia Gravis, Spinal Muscular Atrophy, Inclusion Body Myositis, Primary Lateral Sclerosis.
What interventions are being tested in trial NCT07478172?
The interventions under investigation include: Whole-body Electrical Muscle Stimulation Exercise (DEVICE).
Who is sponsoring clinical trial NCT07478172?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07478172 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07478172's enrollment target sits among peer trials
50 54th of 102 higher than 48 of 102 other Amyotrophic Lateral Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amyotrophic Lateral Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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