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NCT07478172 · ClinicalTrials.gov registry record · NA
Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
A NA study of Amyotrophic Lateral Sclerosis and Myasthenia Gravis, sponsored by University of Missouri-Columbia.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT07478172 is a NA study of Amyotrophic Lateral Sclerosis and Myasthenia Gravis that is actively recruiting participants, run by University of Missouri-Columbia. The registered enrollment target is 50 participants, below the 897-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07478172, a NA study of Amyotrophic Lateral Sclerosis and Myasthenia Gravis, is actively recruiting participants, sponsored by University of Missouri-Columbia.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD). Due to motor unit impairments, NMD patients often cannot tolerate traditional exercise. WB-EMS bypasses voluntary activation limits by directly stimulating muscle contractions. Up to 50 adults with conditions like ALS, SMA, and MG will undergo 20-minute supervised WB-EMS sessions (1-2 times weekly for 4-8 weeks) using the Katalyst system. Outcomes include neural excitability (TMS), motor unit behavior (EMG, NCS), functional tests (walk, balance, strength), and patient-reported fatigue, pain, and quality of life. Strict safety monitoring and exclusion criteria are in place. This study will provide preliminary data on WB-EMS as a potential exercise modality for NMD.
Conditions Studied
Interventions
- DEVICE Whole-body Electrical Muscle Stimulation Exercise
Study Locations (1)
Missouri
- NextGen Precision Health Building, Clinical and Translational Science Unit - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2026-03-10 |
| Est. Completion | 2031-01-07 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07478172
The ClinicalTrials.gov registry entry for NCT07478172 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 897-participant average among 102 other Amyotrophic Lateral Sclerosis trials with a reported enrollment target (94% lower). The listed sponsor is University of Missouri-Columbia, which has 291 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Amyotrophic Lateral Sclerosis appearing as the primary indexed condition, and to 1 intervention - of which Whole-body Electrical Muscle Stimulation Exercise is the first listed.
NCT07478172 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT07478172 about?
NCT07478172 is a clinical study titled "Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease". This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD). Due to motor unit impairments, NMD patients often cannot tolerate traditional exercise. WB-EMS bypasses v...
What is the current status of trial NCT07478172?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2026-03-10. Estimated completion is 2031-01-07.
What conditions does trial NCT07478172 study?
This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis, Myasthenia Gravis, Spinal Muscular Atrophy, Inclusion Body Myositis, Primary Lateral Sclerosis.
What interventions are being tested in trial NCT07478172?
The interventions under investigation include: Whole-body Electrical Muscle Stimulation Exercise (DEVICE).
Who is sponsoring clinical trial NCT07478172?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07478172 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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