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Postpartum Depression clinical trials
Every US clinical trial registered for Postpartum Depression — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
38 US clinical trials · 15 currently recruiting
The research picture
Postpartum Depression has 38 registered US clinical trials, 15 of them open to new participants right now — about 39% of the total.
- 15
- recruiting participants now
- 39%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Women and Infants Hospital of Rhode Island
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention
Michigan State University
NCT05700760
In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression
University of Denver
NCT05766475
Parenting Skills Group for Mothers With Postpartum Depression
University of Colorado, Denver
NCT05772897
Maternal Stress on Human Milk and Infant Outcomes
University of Idaho
NCT04821544
Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication
University of Maryland, College Park
NCT06053515
The Mom and Infant Outcomes (MOMI) Study
Ohio State University
NCT06277661
Improving Maternal Sleep and Mental Health
University of Colorado, Colorado Springs
NCT06544941
Preventing Postpartum Depression in Immigrant Latinas
Northwestern University
NCT05873569
A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone
Biogen
NCT07398469
Maternal Mental Health Access - MaMa
University of Utah
NCT06049433
Understanding the Role of Doulas in Supporting People With PMADs
University of Montana
NCT05763537
Engage & Connect: A Psychotherapy for Postpartum Depression
Weill Medical College of Cornell University
NCT05585164
The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers
Rhode Island Hospital
NCT06737055
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
Grace Lim, MD, MS
NCT06767566
Postpartum Care in the NICU (PeliCaN) Transitions
University of Pennsylvania
NCT06521398
Improving Maternal Mental Health & SUD Screening and Treatment
Medical University of South Carolina
NCT05764213
Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention
Women and Infants Hospital of Rhode Island
NCT06365645
The Maternal Well-Being Study
Texas Tech University Health Sciences Center
NCT05484999
Prenatal Yoga to Prevent Postpartum Depression
Henry Ford Health System
NCT06004232
A Study of Pregnant and Postpartum Women With and Without Mood Disorders
Johns Hopkins University
NCT03615794
A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression
Biogen
NCT02978326
Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers
Women and Infants Hospital of Rhode Island
NCT01482832
Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk
University of Pennsylvania
NCT06276647
The Impact of a Newborn Behavioral Intervention on the Mental Health of Mothers With Late Pre-Term Infants
Brigham and Women's Hospital
NCT03836430
Postpartum Visit Timing and the Effect on Visit Attendance
Women and Infants Hospital of Rhode Island
NCT05399784
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Icahn School of Medicine at Mount Sinai
NCT04017442
A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)
Supernus Pharmaceuticals
NCT02942017
Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms: Impact on Child Development
Children's Hospital of Philadelphia
NCT05400161
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
DuKang Pharmaceuticals
NCT06285916
Postpartum Thyroid Measures and Mood
Oklahoma State University Center for Health Sciences
NCT00565032
The Role of Hormones in Postpartum Mood Disorders
National Institute of Mental Health (NIMH)
NCT00001481
Social Circumstances, Parenting Techniques, and Infant Development
New York State Psychiatric Institute
NCT02121496
A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting
Supernus Pharmaceuticals
NCT05059600
Pilot Trial of CenteringPregnancy With Mindfulness Skills
University of California, San Francis
NCT01646463
Does Enhancing Maternal Peer Interactions Decrease Rates of Postpartum Depression?
Milton S. Hershey Medical Center
NCT03793569
Determining Relationships Among Maternity Stress & Sleep
University of North Carolina, Chapel Hill
NCT02133963
A Postpartum Adaptation Study of the Connecting and Reflecting Experience Parenting Program
Montefiore Medical Center
NCT06042166
Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum Depression
University of North Carolina, Chapel Hill
NCT05543746
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Postpartum Depression Trial Landscape
ClinicalTrials.gov lists 38 US studies indexed under Postpartum Depression, and 15 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Postpartum Depression shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Postpartum Depression is led by Women and Infants Hospital of Rhode Island with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 38 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Postpartum Depression?
PlainTrial tracks 38 US clinical trials for Postpartum Depression, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Postpartum Depression?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.