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Postpartum Depression: later-stage trial registry
21 of 48 indexed Postpartum Depression trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #297 of 28,707 conditions by registered trial count.
48 US clinical trials · 21 currently recruiting · #297 of 28,707 conditions by registered trial count
Postpartum Depression: 48 US clinical trials tracked, 21 recruiting.
Postpartum Depression is the subject of 48 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Women and Infants Hospital of Rhode Island, running 3 of these trials.
Enrollment posture brief
Registry condition postpartum-depression
OPEN 21 | RECR 44% | LATE 5 | EARLY 3 | RANK #297 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute Respiratory Distress Syndrome (44% recruiting · 32 trials)
Postpartum Depression lists 21 open slots (44% of 48 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Postpartum Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Postpartum Depression is recruiting above its size-band peers.
21 of 48 indexed trials (43.8%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Postpartum Depression trials is spread across many organizations.
Women and Infants Hospital of Rhode Island accounts for 3 of 48 trials (6.3%). 36 distinct sponsors appear on at least one study for this condition label.
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Typical Postpartum Depression enrolment sits around 108 participants.
Median target enrolment is 108 among the 48 trials that report a genuine target (sentinel values excluded). 24 of those (50%) plan for fewer than 100 participants.
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Postpartum Depression research is mostly interventional.
42 interventional and 6 observational studies make up this index (87.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
48 total, page 1 of 1
The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention
Michigan State University
NCT05700760
In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression
University of Denver
NCT05766475
Parenting Skills Group for Mothers With Postpartum Depression
University of Colorado, Denver
NCT05772897
Fresh RX: NHS 2020
Washington University School of Medicine
NCT04845230
Maternal Stress on Human Milk and Infant Outcomes
University of Idaho
NCT04821544
Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication
University of Maryland, College Park
NCT06053515
The Mom and Infant Outcomes (MOMI) Study
Ohio State University
NCT06277661
Improving Maternal Sleep and Mental Health
University of Colorado, Colorado Springs
NCT06544941
Preventing Postpartum Depression in Immigrant Latinas
Northwestern University
NCT05873569
A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone
Biogen
NCT07398469
Maternal Mental Health Access - MaMa
University of Utah
NCT06049433
ROSE in Sunset Park
NYU Langone Health
NCT04940585
Understanding the Role of Doulas in Supporting People With PMADs
University of Montana
NCT05763537
OBWELL: Innovative Psychotherapeutic Intervention to Treat Postpartum Depression
Hackensack Meridian Health
NCT06991166
Engage & Connect: A Psychotherapy for Postpartum Depression
Weill Medical College of Cornell University
NCT05585164
The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers
Rhode Island Hospital
NCT06737055
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
Grace Lim, MD, MS
NCT06767566
Accelerated iTBS for Post Partum Depression
Medical University of South Carolina
NCT03417960
Virtual Patient Navigation During a Pandemic
Children's Hospital of Philadelphia
NCT06208852
Accelerated TMS for Perinatal Depression
Brigham and Women's Hospital
NCT06968390
Postpartum Care in the NICU (PeliCaN) Transitions
University of Pennsylvania
NCT06521398
Improving Maternal Mental Health & SUD Screening and Treatment
Medical University of South Carolina
NCT05764213
mHealth Mindfulness Intervention for Pregnant Black and Latina Women at Risk of Postpartum Depression
Kaiser Permanente
NCT05186272
Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention
Women and Infants Hospital of Rhode Island
NCT06365645
The Maternal Well-Being Study
Texas Tech University Health Sciences Center
NCT05484999
Prenatal Yoga to Prevent Postpartum Depression
Henry Ford Health System
NCT06004232
Comparing the Effectiveness of Clinicians and Paraprofessionals to Reduce Disparities in Perinatal Depression
Northwestern University
NCT02979444
A Study of Pregnant and Postpartum Women With and Without Mood Disorders
Johns Hopkins University
NCT03615794
Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women
Ohio State University
NCT03416010
A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression
Biogen
NCT02978326
Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers
Women and Infants Hospital of Rhode Island
NCT01482832
Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk
University of Pennsylvania
NCT06276647
The Impact of a Newborn Behavioral Intervention on the Mental Health of Mothers With Late Pre-Term Infants
Brigham and Women's Hospital
NCT03836430
Postpartum Visit Timing and the Effect on Visit Attendance
Women and Infants Hospital of Rhode Island
NCT05399784
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Icahn School of Medicine at Mount Sinai
NCT04017442
A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)
Supernus Pharmaceuticals
NCT02942017
Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms: Impact on Child Development
Children's Hospital of Philadelphia
NCT05400161
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
DuKang Pharmaceuticals
NCT06285916
Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers
Johns Hopkins University
NCT03638687
Postpartum Thyroid Measures and Mood
Oklahoma State University Center for Health Sciences
NCT00565032
The Role of Hormones in Postpartum Mood Disorders
National Institute of Mental Health (NIMH)
NCT00001481
Social Circumstances, Parenting Techniques, and Infant Development
New York State Psychiatric Institute
NCT02121496
A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting
Supernus Pharmaceuticals
NCT05059600
Pilot Trial of CenteringPregnancy With Mindfulness Skills
University of California, San Francisco
NCT01646463
Does Enhancing Maternal Peer Interactions Decrease Rates of Postpartum Depression?
Milton S. Hershey Medical Center
NCT03793569
Determining Relationships Among Maternity Stress & Sleep
University of North Carolina, Chapel Hill
NCT02133963
A Postpartum Adaptation Study of the Connecting and Reflecting Experience Parenting Program
Montefiore Medical Center
NCT06042166
Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum Depression
University of North Carolina, Chapel Hill
NCT05543746
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Postpartum Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Postpartum Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Postpartum Depression page
48 registered trials, 21 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 21 Postpartum Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Women and Infants Hospital of Rhode Island sponsors the most Postpartum Depression trials on record, review their full trial history before evaluating a specific study. See Women and Infants Hospital of Rhode Island's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Postpartum Depression condition card totals 48 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.