Supernus Pharmaceuticals

57 total trials 6 currently recruiting 45 completed

Supernus Pharmaceuticals sponsors 57 registered US clinical trials on ClinicalTrials.gov, 6 of them currently recruiting, and 45 completed. 26 of these trials are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Sialorrhea, with 2 trials.

Trial Pipeline

57 total, page 1 of 2

RECRUITING Phase 2

Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

NCT07226661

RECRUITING Phase 2

SPN-817 Open-Label Extension Study in Adults With Focal Onset Seizures

NCT07141329

RECRUITING

Real-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States:

NCT07219927

RECRUITING Phase 2

RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults with Focal Onset Seizures

NCT06798896

RECRUITING Phase 4

Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD

NCT04781140

RECRUITING Phase 2

Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy

NCT05518578

ACTIVE NOT RECRUITING Phase 3

Open-label Study to Evaluate Long-term Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule)

NCT02736656

COMPLETED Phase 4

Open-label Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD and Mood Symptoms

NCT06185985

COMPLETED Phase 4

Evaluation of Viloxazine and Its Metabolite 5-Hydroxy-viloxazine Glucuronide Into Breast Milk in Healthy Lactating Women

NCT06259331

COMPLETED Phase 2

An Open-Label Study Evaluating Brexanolone in Adults With Tinnitus

NCT05645432

TERMINATED Phase 3

A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease

NCT05655520

COMPLETED Phase 2

A Study to Evaluate the Effects of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)

NCT05619692

COMPLETED Phase 2

A Study to Evaluate the Effects of SAGE-718 in Participants With Parkinson's Disease Cognitive Impairment

NCT05318937

COMPLETED Phase 2

28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease

NCT05358821

COMPLETED Phase 2

A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)

NCT05107128

COMPLETED Phase 4

A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting

NCT05059600

COMPLETED Phase 1

Study of SAGE-904 Using a Ketamine Challenge to Evaluate Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy Participants

NCT05049343

COMPLETED Phase 4

Open-Label Study of SPN-812 Administered With Psychostimulants in Children and Adolescents With ADHD

NCT04786990

COMPLETED Phase 2

A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)

NCT04602624

COMPLETED Phase 2

A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Parkinson's Disease Mild Cognitive Impairment (PD-MCI)

NCT04476017

TERMINATED Phase 4

Therapy for Migraine Prevention in Children 6-11 Years of Age

NCT04050293

COMPLETED Phase 3

Open-label Long-Term Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD

NCT04143217

COMPLETED Phase 3

Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD

NCT04016779

TERMINATED Phase 2

Exploratory fMRI Study on the Treatment for Impulsive Aggression in Children With ADHD

NCT03638466

COMPLETED Phase 1

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B

NCT03787758

COMPLETED Phase 1

A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects

NCT03844906

COMPLETED Phase 1

A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

NCT03770780

COMPLETED Phase 1

A Study to Assess the Electrophysiology, Safety, Tolerability, and Pharmacokinetics of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

NCT03771586

COMPLETED Phase 3

A Study to Assess the Safety of Brexanolone in the Treatment of Adolescent Female Participants With Postpartum Depression (PPD)

NCT03665038

COMPLETED

Functional MRI Study in Healthy Children Engaged in Aggressive Behaviors

NCT03615703

TERMINATED Phase 3

Treatment of Impulsive Aggression (IA) in Adolescent With ADHD in Conjunction With Standard ADHD Treatment

NCT03597503

COMPLETED

Clinical Outcome Assessment of Parkinson's Disease Patients Treated With XADAGO (Safinamide)

NCT03944785

COMPLETED Phase 3

Evaluation of SPN-812 (Viloxazine Extended-release Capsule) High Dose in Adolescents With ADHD

NCT03247556

COMPLETED Phase 3

Evaluation of SPN-812 (Viloxazine Extended-release Capsule) Low Dose in Adolescents With ADHD

NCT03247517

COMPLETED Phase 3

Evaluation of SPN-812 (Viloxazine Extended-release Capsule) High Dose in Children With ADHD

NCT03247543

COMPLETED Phase 3

Evaluation of SPN-812 (Viloxazine Extended-release Capsule) Low Dose in Children With ADHD

NCT03247530

COMPLETED Phase 3

A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)

NCT02942004

COMPLETED Phase 3

A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)

NCT02942017

TERMINATED Phase 3

Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 4)

NCT02691182

COMPLETED Phase 3

Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 2)

NCT02618434

COMPLETED Phase 2

Efficacy and Safety of SPN-812 (Viloxazine Extended-release Capsule) in Children With ADHD

NCT02633527

COMPLETED Phase 3

Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 1)

NCT02618408

COMPLETED Phase 2

A Study to Evaluate SAGE-547 in Participants With Severe Postpartum Depression

NCT02614547

COMPLETED Phase 3

Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults

NCT02610868

COMPLETED Phase 3

A Study With SAGE-547 for Super-Refractory Status Epilepticus

NCT02477618

COMPLETED Phase 2

Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression

NCT02285504

COMPLETED Phase 1

Study to Evaluate SAGE-547 Injection as Adjunctive Therapy for the Treatment of Super-Refractory Status Epilepticus

NCT02052739

COMPLETED Phase 3

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects

NCT01994109

COMPLETED Phase 2

Open-Label, Extension Study to 810P202

NCT01416064

COMPLETED Phase 2

A Study to Evaluate the Efficacy and Safety of SPN-810 as Adjunctive Therapy in Children With Impulsive Aggression Comorbid With Attention-Deficit/Hyperactivity Disorder (ADHD)

NCT01364662

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What the Pipeline for Supernus Pharmaceuticals Shows

According to the ClinicalTrials.gov registry, Supernus Pharmaceuticals is linked to 57 US clinical trials across every stage of research activity. Of those, 6 studies are currently recruiting, about 11% of the sponsor's indexed portfolio, and 45 are already marked complete, representing roughly 79% of the total.

The phase mix for Supernus Pharmaceuticals reports 26 late-stage studies (Phase 3 and Phase 4 combined) and 28 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Supernus Pharmaceuticals is Sialorrhea with 2 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.