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Post Operative Pain clinical trials
27 of 57 indexed Post Operative Pain trials are currently recruiting.
57 US clinical trials · 27 currently recruiting
Post Operative Pain is the subject of 57 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 4 of these trials.
The research picture
Post Operative Pain has 57 registered US clinical trials, 27 of them open to new participants right now, about 47% of the total.
- 27
- recruiting participants now
- 47%
- of trials open to enrollment
- 27
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Medical University of South Carolina
Active & Recent Trials
57 total, page 1 of 2
A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves
AtriCure
NCT05110989
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Thomas Jefferson University
NCT07102641
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
Simethicone as Part of ERAS in Bariatric Surgery Patients
Madigan Army Medical Center
NCT06812832
ZYNRELEF for Pain Management in Total Knee Arthroplasty
Baptist Health South Florida
NCT05644496
Methadone in TKA for Post-op Pain and Opioid Reduction
Medical University of South Carolina
NCT07226076
Methadone in THA for Post-op Pain and Opioid Reduction
Medical University of South Carolina
NCT07227064
Dextromethorphan for Treatment of Postoperative Pain
Nathanael Heckmann
NCT05278494
Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy
Texas Tech University Health Sciences Center
NCT06349772
Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine
Boston Children's Hospital
NCT06471348
Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty
Connecticut Children's Medical Center
NCT05898087
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The Cleveland Clinic
NCT07222072
Opioid Use After Laparoscopic Salpingectomy
Johns Hopkins University
NCT06434233
Pain With Differing Insufflation Pressures During Laparoscopic Hysterectomy
University of Tennessee
NCT06508814
Preoperative Acetazolamide
Prisma Health-Upstate
NCT07101250
Force Sensor Study
University of California, San Francisco
NCT07434583
Post-operative Cesarean Trial of Pain Control
University of Colorado, Denver
NCT05131178
Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy
Ricard Corcelles
NCT06425016
A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi
Mayo Clinic
NCT07223580
Liposomal Bupivacaine and Transoral Robotic Surgery
Geisinger Clinic
NCT05862792
Post Operative Infusion Pump Pain Study
Rutgers, The State University of New Jersey
NCT07349810
Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
University of Texas Southwestern Medical Center
NCT06158620
Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties
Melinda Seering
NCT05868330
Temperature Rise Caused by Short or Long-wavelengths
University of Florida
NCT06418958
QL vs LAI for Palatoplasty
Medical University of South Carolina
NCT06420336
Sensory Outcomes in Active Substance Users
Boston Medical Center
NCT06639438
Dextenza in the Post-op Management of Vitreoretinal Surgeries
The Cleveland Clinic
NCT04371445
Quality of Recovery From Mastectomy With and Without PECS Blocks
Endeavor Health
NCT05795413
Comparing Perioperative Outcomes in Pain Control
University of California, San Diego
NCT05690282
ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
University of California, Davis
NCT05805423
Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy
Viatris Specialty
NCT06215859
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
Talphera
NCT01539538
Maxigesic IV Phase 3 Bunionectomy Study
AFT Pharmaceuticals
NCT02689063
Ibuprofen Extended-Release Dental Pain Study
SCOLR Pharma
NCT00707057
An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.
Lotus Clinical Research
NCT02101476
Pharmacogenetic-guided Choice of Post-surgery Analgesics
University of Pennsylvania
NCT05548660
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
Mylan Specialty
NCT05317312
Acupuncture for Post-Operative Pain Control for Patients Undergoing Gynecological Surgery
Icahn School of Medicine at Mount Sinai
NCT02855567
A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Elective Unilateral Total Knee Replacement
Talphera
NCT00612534
Proximal Versus Distal Adductor Canal Blocks for Total Knee Arthroplasty
Benaroya Research Institute
NCT02701114
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
University of Wisconsin, Madison
NCT01444924
Oral vs Intravenous Acetominophen for Postoperative Pain in Minimally Invasive Gynecologic Surgery
Scripps Health
NCT03391284
Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions
University of Southern California
NCT05374499
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectomy
Vivozon
NCT02992041
Efficacy of IV Acetaminophen for Pain Management
Aultman Health Foundation
NCT02028715
IV Acetaminophen for Acute Post Operative Pain in C-Section Patients
Montefiore Medical Center
NCT02069184
Postoperative Pain Control in Septum and Sinus Surgery
Corewell Health East
NCT04149964
Preoperative Pain Control in Gastric Bypass Surgery Patients
Legacy Health System
NCT01801189
Optimization of Catheter Insertion Site for Continuous Peripheral Nerve Blocks
University of California, San Diego
NCT00876746
Methadone in Ambulatory Surgery
Washington University School of Medicine
NCT02300077
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 4 |
| Phase 3 | 6 |
| Phase 4 | 21 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Post Operative Pain Trial Landscape
57 indexed Post Operative Pain studies · 27 recruiting (47%).
Phase mix: 27 late (III/IV) vs 8 early (I/II).
Top sponsor: Medical University of South Carolina (4 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Post Operative Pain?
PlainTrial tracks 57 US clinical trials for Post Operative Pain, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Post Operative Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.