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ClinicalTrials.gov 27 recruiting now official registry

Post Operative Pain clinical trials

27 of 57 indexed Post Operative Pain trials are currently recruiting.

57 US clinical trials · 27 currently recruiting

Post Operative Pain is the subject of 57 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 4 of these trials.

The research picture

Post Operative Pain has 57 registered US clinical trials, 27 of them open to new participants right now, about 47% of the total.

27
recruiting participants now
47%
of trials open to enrollment
27
in Phase 3–4 (later-stage)
4
top sponsor: Medical University of South Carolina
Phase 14Phase 24Phase 36Phase 421

Active & Recent Trials

57 total, page 1 of 2

RECRUITING 5,000 participants

A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves

AtriCure

NCT05110989

RECRUITING Phase 4 825 participants

Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies

Thomas Jefferson University

NCT07102641

RECRUITING 800 participants

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

Brown University

NCT05754190

RECRUITING Phase 4 260 participants

Simethicone as Part of ERAS in Bariatric Surgery Patients

Madigan Army Medical Center

NCT06812832

RECRUITING Phase 4 242 participants

ZYNRELEF for Pain Management in Total Knee Arthroplasty

Baptist Health South Florida

NCT05644496

RECRUITING Phase 3 162 participants

Methadone in TKA for Post-op Pain and Opioid Reduction

Medical University of South Carolina

NCT07226076

RECRUITING Phase 3 162 participants

Methadone in THA for Post-op Pain and Opioid Reduction

Medical University of South Carolina

NCT07227064

RECRUITING NA 160 participants

Dextromethorphan for Treatment of Postoperative Pain

Nathanael Heckmann

NCT05278494

RECRUITING Early Phase 1 130 participants

Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy

Texas Tech University Health Sciences Center

NCT06349772

RECRUITING NA 128 participants

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

Boston Children's Hospital

NCT06471348

RECRUITING Phase 4 128 participants

Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty

Connecticut Children's Medical Center

NCT05898087

RECRUITING Phase 4 120 participants

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

The Cleveland Clinic

NCT07222072

RECRUITING Phase 4 120 participants

Opioid Use After Laparoscopic Salpingectomy

Johns Hopkins University

NCT06434233

RECRUITING NA 100 participants

Pain With Differing Insufflation Pressures During Laparoscopic Hysterectomy

University of Tennessee

NCT06508814

RECRUITING Phase 4 100 participants

Preoperative Acetazolamide

Prisma Health-Upstate

NCT07101250

RECRUITING NA 100 participants

Force Sensor Study

University of California, San Francisco

NCT07434583

RECRUITING NA 100 participants

Post-operative Cesarean Trial of Pain Control

University of Colorado, Denver

NCT05131178

RECRUITING NA 91 participants

Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy

Ricard Corcelles

NCT06425016

RECRUITING Phase 4 90 participants

A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi

Mayo Clinic

NCT07223580

RECRUITING 80 participants

Liposomal Bupivacaine and Transoral Robotic Surgery

Geisinger Clinic

NCT05862792

RECRUITING Phase 4 80 participants

Post Operative Infusion Pump Pain Study

Rutgers, The State University of New Jersey

NCT07349810

RECRUITING Phase 1 80 participants

Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

University of Texas Southwestern Medical Center

NCT06158620

RECRUITING Phase 4 56 participants

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

Melinda Seering

NCT05868330

RECRUITING NA 50 participants

Temperature Rise Caused by Short or Long-wavelengths

University of Florida

NCT06418958

RECRUITING NA 46 participants

QL vs LAI for Palatoplasty

Medical University of South Carolina

NCT06420336

RECRUITING 40 participants

Sensory Outcomes in Active Substance Users

Boston Medical Center

NCT06639438

RECRUITING Phase 4 30 participants

Dextenza in the Post-op Management of Vitreoretinal Surgeries

The Cleveland Clinic

NCT04371445

ACTIVE NOT RECRUITING 800 participants

Quality of Recovery From Mastectomy With and Without PECS Blocks

Endeavor Health

NCT05795413

ACTIVE NOT RECRUITING Phase 4 100 participants

Comparing Perioperative Outcomes in Pain Control

University of California, San Diego

NCT05690282

ACTIVE NOT RECRUITING NA 74 participants

ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery

University of California, Davis

NCT05805423

COMPLETED Phase 3 579 participants

Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy

Viatris Specialty

NCT06215859

COMPLETED Phase 3 357 participants

A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain

Talphera

NCT01539538

COMPLETED Phase 3 276 participants

Maxigesic IV Phase 3 Bunionectomy Study

AFT Pharmaceuticals

NCT02689063

COMPLETED Phase 3 256 participants

Ibuprofen Extended-Release Dental Pain Study

SCOLR Pharma

NCT00707057

COMPLETED Phase 4 114 participants

An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.

Lotus Clinical Research

NCT02101476

COMPLETED NA 112 participants

Pharmacogenetic-guided Choice of Post-surgery Analgesics

University of Pennsylvania

NCT05548660

COMPLETED Phase 2 111 participants

Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.

Mylan Specialty

NCT05317312

COMPLETED NA 110 participants

Acupuncture for Post-Operative Pain Control for Patients Undergoing Gynecological Surgery

Icahn School of Medicine at Mount Sinai

NCT02855567

COMPLETED Phase 2 94 participants

A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Elective Unilateral Total Knee Replacement

Talphera

NCT00612534

COMPLETED NA 76 participants

Proximal Versus Distal Adductor Canal Blocks for Total Knee Arthroplasty

Benaroya Research Institute

NCT02701114

COMPLETED Phase 2 75 participants

Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery

University of Wisconsin, Madison

NCT01444924

COMPLETED NA 75 participants

Oral vs Intravenous Acetominophen for Postoperative Pain in Minimally Invasive Gynecologic Surgery

Scripps Health

NCT03391284

COMPLETED Phase 4 73 participants

Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions

University of Southern California

NCT05374499

COMPLETED Phase 2 69 participants

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectomy

Vivozon

NCT02992041

COMPLETED Phase 4 68 participants

Efficacy of IV Acetaminophen for Pain Management

Aultman Health Foundation

NCT02028715

COMPLETED Phase 4 66 participants

IV Acetaminophen for Acute Post Operative Pain in C-Section Patients

Montefiore Medical Center

NCT02069184

COMPLETED Phase 4 65 participants

Postoperative Pain Control in Septum and Sinus Surgery

Corewell Health East

NCT04149964

COMPLETED Phase 4 61 participants

Preoperative Pain Control in Gastric Bypass Surgery Patients

Legacy Health System

NCT01801189

COMPLETED Phase 4 60 participants

Optimization of Catheter Insertion Site for Continuous Peripheral Nerve Blocks

University of California, San Diego

NCT00876746

COMPLETED NA 60 participants

Methadone in Ambulatory Surgery

Washington University School of Medicine

NCT02300077

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 4
Phase 3 6
Phase 4 21

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Post Operative Pain Trial Landscape

57 indexed Post Operative Pain studies · 27 recruiting (47%).

Phase mix: 27 late (III/IV) vs 8 early (I/II).

Top sponsor: Medical University of South Carolina (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Post Operative Pain?

PlainTrial tracks 57 US clinical trials for Post Operative Pain, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Post Operative Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.