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Post Operative Pain
Open-data reference.
28 US clinical trials · 17 currently recruiting
Active & Recent Trials
A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves
AtriCure
NCT05110989
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
ZYNRELEF for Pain Management in Total Knee Arthroplasty
Baptist Health South Florida
NCT05644496
Methadone in TKA for Post-op Pain and Opioid Reduction
Medical University of South Carolina
NCT07226076
Methadone in THA for Post-op Pain and Opioid Reduction
Medical University of South Carolina
NCT07227064
Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy
Texas Tech University Health Sciences Center
NCT06349772
Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine
Boston Children's Hospital
NCT06471348
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The Cleveland Clinic
NCT07222072
Pain With Differing Insufflation Pressures During Laparoscopic Hysterectomy
University of Tennessee
NCT06508814
Preoperative Acetazolamide
Prisma Health-Upstate
NCT07101250
Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy
Ricard Corcelles
NCT06425016
A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi
Mayo Clinic
NCT07223580
Liposomal Bupivacaine and Transoral Robotic Surgery
Geisinger Clinic
NCT05862792
Post Operative Infusion Pump Pain Study
Rutgers, The State University of New Jersey
NCT07349810
Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
University of Texas Southwestern Medical Center
NCT06158620
Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties
Melinda Seering
NCT05868330
Sensory Outcomes in Active Substance Users
Boston Medical Center
NCT06639438
Quality of Recovery From Mastectomy With and Without PECS Blocks
Endeavor Health
NCT05795413
ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
University of California, Davis
NCT05805423
Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy
Viatris Specialty
NCT06215859
Maxigesic IV Phase 3 Bunionectomy Study
AFT Pharmaceuticals
NCT02689063
An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.
Lotus Clinical Research
NCT02101476
Pharmacogenetic-guided Choice of Post-surgery Analgesics
University of Pennsylvania
NCT05548660
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
Mylan Specialty
NCT05317312
A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Elective Unilateral Total Knee Replacement
Talphera
NCT00612534
Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions
University of Southern California
NCT05374499
Opioid Education in Total Knee Arthroplasty
Hospital for Special Surgery, New York
NCT05593341
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
University of Washington
NCT05338671
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Post Operative Pain Trial Landscape
ClinicalTrials.gov lists 28 US studies indexed under Post Operative Pain, and 17 of those are currently open to recruitment — roughly 61% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Post Operative Pain shows 13 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Post Operative Pain is led by Medical University of South Carolina with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 28 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Post Operative Pain?
PlainTrial tracks 28 US clinical trials for Post Operative Pain, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Post Operative Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.