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ACTIVE NOT RECRUITING Phase 2

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors

NCT02498613 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other parts of the body (advanced/metastatic) or cannot be removed by surgery (unresectable), including breast cancer, non-small cell lung cancer, small cell lung cancer, and pancreatic cancer. Cediranib maleate and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cediranib maleate may also block the flow of oxygen to the tumor, and may help make the tumor more sensitive to olaparib.

Interventions

  • PROCEDURE Positron Emission Tomography
  • OTHER Laboratory Biomarker Analysis
  • DRUG Olaparib
  • DRUG Cediranib Maleate
  • OTHER 18F-Fluoromisonidazole

Study Locations (16)

California

  • UC San Diego Moores Cancer Center — La Jolla
  • University of California Davis Comprehensive Cancer Center — Sacramento
  • UC San Diego Medical Center - Hillcrest — San Diego
  • UCSF Medical Center-Mount Zion — San Francisco

Connecticut

  • Smilow Cancer Center/Yale-New Haven Hospital — New Haven
  • Yale University — New Haven

Florida

  • Moffitt Cancer Center-International Plaza — Tampa
  • Moffitt Cancer Center — Tampa

Michigan

  • Wayne State University/Karmanos Cancer Institute — Detroit
  • Weisberg Cancer Treatment Center — Farmington Hills

Massachusetts

  • Dana-Farber Cancer Institute — Boston

Tennessee

  • Vanderbilt University/Ingram Cancer Center — Nashville

Texas

  • M D Anderson Cancer Center — Houston

Virginia

  • VCU Massey Comprehensive Cancer Center — Richmond

Trial Details

FieldValue
Enrollment Target 122 participants
Start Date 2016-08-31
Est. Completion 2026-04-10
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02498613

The ClinicalTrials.gov registry entry for NCT02498613 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 122 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Advanced Malignant Solid Neoplasm appearing as the primary indexed condition, and to 5 interventions — of which Positron Emission Tomography is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02498613 reports 16 study locations spanning 10 distinct geographic areas — top geographies include California, Connecticut, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02498613 about?

NCT02498613 is a clinical study titled "A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors". This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other parts of the body (advanced/metastatic) or cannot be removed by surgery (unresectable), including breast cancer, non-small cell lung cancer, small cell lung can...

What is the current status of trial NCT02498613?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 122 participants. The study started on 2016-08-31. Estimated completion is 2026-04-10.

What conditions does trial NCT02498613 study?

This clinical trial studies the following conditions: Advanced Malignant Solid Neoplasm, Pancreatic Ductal Adenocarcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Pancreatic Adenocarcinoma, Metastatic Triple-Negative Breast Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02498613?

The interventions under investigation include: Positron Emission Tomography (PROCEDURE), Laboratory Biomarker Analysis (OTHER), Olaparib (DRUG), Cediranib Maleate (DRUG), 18F-Fluoromisonidazole (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02498613?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02498613 being conducted?

This trial has 16 study locations across California, Connecticut, Florida, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial