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ClinicalTrials.gov 30 recruiting now official registry

Pancreas Cancer clinical trials

Every US clinical trial registered for Pancreas Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

55 US clinical trials · 30 currently recruiting

The research picture

Pancreas Cancer has 55 registered US clinical trials, 30 of them open to new participants right now — about 55% of the total.

30
recruiting participants now
55%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: A2 Biotherapeutics

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 20,000 participants

Pancreatic Cancer Early Detection Consortium

Arbor Research Collaborative for Health

NCT04970056

RECRUITING Phase 3 9,000 participants

The Cancer of the Pancreas Screening-5 CAPS5)Study

Johns Hopkins University

NCT02000089

RECRUITING 5,000 participants

ARGONAUT: Stool and Blood Sample Bank for Cancer Patients

Persephone Biosciences

NCT04638751

RECRUITING 5,000 participants

Diagnostic Strategies, Risk Assessment and Progression of Pancreatic Cysts

Johns Hopkins University

NCT04473794

RECRUITING 1,800 participants

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

National Cancer Institute (NCI)

NCT01915225

RECRUITING 1,368 participants

Pancreas Registry and High Risk Registry

Icahn School of Medicine at Mount Sinai

NCT02775461

RECRUITING 1,000 participants

ExoLuminate Study for Early Detection of Pancreatic Cancer

Biological Dynamics

NCT05625529

RECRUITING Phase 1 474 participants

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06051695

RECRUITING 400 participants

Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection

University of Colorado, Denver

NCT05517811

RECRUITING NA 397 participants

Stereotactic Magnetic Resonance Guided Radiation Therapy

Dana-Farber Cancer Institute

NCT04115254

RECRUITING NA 360 participants

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Cedars-Sinai Medical Center

NCT04907643

RECRUITING Phase 1 292 participants

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Bicara Therapeutics

NCT04429542

RECRUITING Phase 1 220 participants

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06545942

RECRUITING NA 200 participants

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

Case Comprehensive Cancer Center

NCT06263088

RECRUITING 200 participants

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

A2 Biotherapeutics

NCT04981119

RECRUITING Phase 1 100 participants

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Nammi Therapeutics

NCT06582017

RECRUITING Phase 3 80 participants

Extending Outcomes for Pancreas Cancer Patients With Nominal Oligometastatic Disease (EXPAND): A Randomized Phase III Trial

M.D. Anderson Cancer Center

NCT06593431

RECRUITING Phase 2 72 participants

Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury

Massachusetts General Hospital

NCT04485286

RECRUITING NA 60 participants

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

Washington University School of Medicine

NCT05975593

RECRUITING 50 participants

ctDNA Assay in Patients With Resectable Pancreatic Cancer

University of Oklahoma

NCT05052671

RECRUITING NA 48 participants

Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer

Baptist Health South Florida

NCT05679674

RECRUITING NA 40 participants

Molecular Profile-related Individualized Targeted Therapy in Resected Pancreatic Cancer With High-Risk of Cancer Recurrence

Medical College of Wisconsin

NCT06228599

RECRUITING Phase 1 40 participants

Nab-Paclitaxel + Cisplatin + Gemcitabine + TTF in pt. w/ Metastatic PAC

Mayo Clinic

NCT04605913

RECRUITING Phase 2 37 participants

Stimulation With Bethanechol in Combination With Gemcitabine and Nab-paclitaxel in Pancreatic Adenocarcinoma

Susan E. Bates

NCT05241249

RECRUITING 30 participants

Collection of Circulating Biomarkers in Pancreatic Cancer

Abramson Cancer Center at Penn Medicine

NCT05743049

RECRUITING 30 participants

Pancreatic Cancer & Surgical Resection

Methodist Health System

NCT05170802

RECRUITING Phase 1 27 participants

Autologous CAR-T Cells Targeting B7-H3 in PDAC

UNC Lineberger Comprehensive Cancer Center

NCT06158139

RECRUITING NA 26 participants

Promoting CT Engagement for Pancreatic Cancer With App

UNC Lineberger Comprehensive Cancer Center

NCT06252545

RECRUITING Phase 1 23 participants

Study of EGFRBi Armed Fresh PBMC in Metastatic or Unresectable Pancreatic Cancer

University of Virginia

NCT06479239

RECRUITING Phase 1 20 participants

Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

University of Louisville

NCT03484299

ACTIVE NOT RECRUITING 1,047 participants

Evaluating an Alternative Clinical Genetics Cancer Care Delivery Model: A Pilot Study of Patient Outcomes

Memorial Sloan Kettering Cancer Center

NCT02917798

ACTIVE NOT RECRUITING NA 199 participants

Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement

Massachusetts General Hospital

NCT03716531

ACTIVE NOT RECRUITING Phase 1 163 participants

First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05156866

ACTIVE NOT RECRUITING Phase 1 160 participants

A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT05736731

ACTIVE NOT RECRUITING Phase 1 130 participants

Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors

Cybrexa Therapeutics

NCT04902872

ACTIVE NOT RECRUITING 100 participants

Pancreatic Cancer Early Detection Program

White Plains Hospital

NCT02206360

ACTIVE NOT RECRUITING Phase 1 70 participants

First in Human Study of TORL-2-307-MAB in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05159440

ACTIVE NOT RECRUITING Phase 1 50 participants

CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab

Anup Kasi

NCT05121038

ACTIVE NOT RECRUITING Phase 2 42 participants

Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma

Washington University School of Medicine

NCT04331041

ACTIVE NOT RECRUITING Phase 1 40 participants

Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer

Verastem

NCT05669482

ACTIVE NOT RECRUITING Phase 1 39 participants

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

DEKA Biosciences

NCT05704985

ACTIVE NOT RECRUITING Phase 2 32 participants

Adaptive Approach to Neoadjuvant Therapy to Maximize Resection Rates for Pancreatic Adenocarcinoma

University of Cincinnati

NCT04594772

ACTIVE NOT RECRUITING Phase 2 28 participants

Enfortumab Vedotin in Previously Treated Locally Advanced or Metastatic Pancreatic Cancer (EPIC)

University of Kansas Medical Center

NCT05915351

ACTIVE NOT RECRUITING Early Phase 1 28 participants

A Feasibility Study of Ketorolac Treatment for Cachexia in Patients With Advanced Pancreatic Ductal Adenocarcinoma

Andrew Hendifar, MD

NCT05336266

ACTIVE NOT RECRUITING Phase 2 24 participants

Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer

University of Kansas Medical Center

NCT05638698

ACTIVE NOT RECRUITING Phase 1 24 participants

Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers

University of Nebraska

NCT05220046

ACTIVE NOT RECRUITING NA 19 participants

An Ultrasound Imaging Technique to Measure Tumors in People With Pancreatic Ductal Adenocarcinoma (PDAC) or Gastrointestinal (GI) Adenocarcinoma

Memorial Sloan Kettering Cancer Center

NCT04837833

ACTIVE NOT RECRUITING Phase 1 19 participants

A Phase 1b Study of Gemcitabine and Nab-paclitaxel in Combination With IM156 in Patients With Advanced Pancreatic Cancer.

M.D. Anderson Cancer Center

NCT05497778

ACTIVE NOT RECRUITING NA 16 participants

A Supervised Prehabilitation Program for Patients With Pancreatic Cancer

Cedars-Sinai Medical Center

NCT05692323

ACTIVE NOT RECRUITING Phase 2 12 participants

Phase II Trial of Vemurafenib and Sorafenib in Pancreatic Cancer

HonorHealth Research Institute

NCT05068752

COMPLETED Phase 2 176 participants

Safety and Efficacy of the Therapeutic Vaccine GI-4000 in Combination With Gemcitabine Versus Placebo for the Treatment of Non-metastatic, Post-resection Pancreas Cancer

GlobeImmune

NCT00300950

COMPLETED Phase 1 65 participants

Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer

National Cancer Institute (NCI)

NCT02311361

COMPLETED NA 60 participants

Supportive Oncology Care at Home for Patients With Pancreatic Cancer Receiving Preoperative FOLFIRINOX

Massachusetts General Hospital

NCT03798769

COMPLETED Phase 1 33 participants

Neoantigen Vaccines in Pancreatic Cancer in the Window Prior to Surgery

Washington University School of Medicine

NCT05111353

COMPLETED Phase 1 23 participants

Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies

Novita Pharmaceuticals

NCT03199586

Phase Distribution

PhaseTrial count
Phase 1 21
Phase 2 8
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pancreas Cancer Trial Landscape

ClinicalTrials.gov lists 55 US studies indexed under Pancreas Cancer, and 30 of those are currently open to recruitment — roughly 55% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Pancreas Cancer shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 29 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Pancreas Cancer is led by A2 Biotherapeutics with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 55 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pancreas Cancer?

PlainTrial tracks 55 US clinical trials for Pancreas Cancer, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pancreas Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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