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NCT06069622 · ClinicalTrials.gov registry record
Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment
A clinical trial of Overweight and Obesity, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- 30
- Enrollment target
- 1
- Study location
NCT06069622 is a study of Overweight and Obesity that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 30 participants, below the 228-participant average among 115 other Overweight and Obesity trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06069622, a study of Overweight and Obesity, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Obesity has become an important public health issue that leads to insulin resistance, diabetes, hypertension, dyslipidemia, and cardiovascular diseases. Although weight loss with calorie restriction and increased physical activity improve these complications, many people fail these lifestyle interventions. Therefore, pharmacologic agents have been used for weight management in addition to lifestyle interventions. In the past few years, one of the widely used pharmacologic agents for weight management is Glucagon-like peptide 1 receptor agonists (GLP1 RAs). Overall, this class of medications improves both metabolic and cardiovascular profiles while causing weight loss, but their effects can vary between individuals. Therefore, it is essential to understand who will respond best to this therapy. Based on previous research on the interaction between a cell membrane molecule, caveolin-1, and glucagon-like peptide 1 receptor, we hypothesize that genetic variations in the caveolin-1 gene explain the variable cardiometabolic responses.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST 24-hour ambulatory blood pressure
- DIETARY_SUPPLEMENT Liberal salt diet
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2023-11-01 |
| Est. Completion | 2026-11-30 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06069622
The ClinicalTrials.gov registry entry for NCT06069622 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 228-participant average among 115 other Overweight and Obesity trials with a reported enrollment target (87% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Overweight and Obesity appearing as the primary indexed condition, and to 2 interventions - of which 24-hour ambulatory blood pressure is the first listed.
NCT06069622 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06069622 about?
NCT06069622 is a clinical study titled "Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment". Obesity has become an important public health issue that leads to insulin resistance, diabetes, hypertension, dyslipidemia, and cardiovascular diseases. Although weight loss with calorie restriction and increased physical activity improve these complications, many people fail these lifestyle interve...
What is the current status of trial NCT06069622?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2023-11-01. Estimated completion is 2026-11-30.
What conditions does trial NCT06069622 study?
This clinical trial studies the following conditions: Overweight and Obesity.
What interventions are being tested in trial NCT06069622?
The interventions under investigation include: 24-hour ambulatory blood pressure (DIAGNOSTIC_TEST), Liberal salt diet (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06069622?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06069622 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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