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ClinicalTrials.gov 8 recruiting now official registry

Orthostatic Hypotension clinical trials

Every US clinical trial registered for Orthostatic Hypotension — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

17 US clinical trials · 8 currently recruiting

The research picture

Orthostatic Hypotension has 17 registered US clinical trials, 8 of them open to new participants right now — about 47% of the total.

8
recruiting participants now
47%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Vanderbilt University Medical Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 69 participants

Deciphering Preserved Autonomic Function After Spinal Cord Injury

Mayo Clinic

NCT04493372

RECRUITING NA 60 participants

Blood Pressure Effects on Cognition and Brain Blood Flow in PD

University of California, San Diego

NCT05400174

RECRUITING Phase 1 34 participants

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Vanderbilt University Medical Center

NCT02897063

RECRUITING Phase 1 31 participants

Automated Abdominal Binder for Orthostatic Hypotension

Vanderbilt University Medical Center

NCT03482297

RECRUITING Phase 1 29 participants

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Vanderbilt University Medical Center

NCT02429557

RECRUITING NA 20 participants

Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury

James J. Peters Veterans Affairs Medical Center

NCT05960448

RECRUITING NA 12 participants

Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

Kessler Foundation

NCT05731986

RECRUITING NA 5 participants

The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)

Kessler Foundation

NCT05725499

ACTIVE NOT RECRUITING NA 35 participants

Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI

Methodist Rehabilitation Center

NCT04029974

ACTIVE NOT RECRUITING NA 20 participants

Water and the Gastropressor Response - Diurnal Variability

Satish R. Raj

NCT00581373

ACTIVE NOT RECRUITING NA 20 participants

Water and the Gastropressor Response - Tachyphylaxis

Satish R. Raj

NCT00580996

ACTIVE NOT RECRUITING Phase 1 2 participants

Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic

Vanderbilt University

NCT02726711

COMPLETED NA 356 participants

Orthostatic Hypotension Treatment on Rehab Unit

VA Office of Research and Development

NCT01030874

COMPLETED 50 participants

Data Collection - Of Syncope Tilt Table Testing Study

Boston Scientific Corporation

NCT03721393

COMPLETED Phase 2 45 participants

The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

Brigham and Women's Hospital

NCT03674541

COMPLETED Phase 2 34 participants

Safety and Efficacy of L-NAME and Midodrine to Increase MAP

US Department of Veterans Affairs

NCT00835224

COMPLETED NA 13 participants

Abdominal Compression in Orthostatic Hypotension

Mayo Clinic

NCT01223391

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Orthostatic Hypotension Trial Landscape

ClinicalTrials.gov lists 17 US studies indexed under Orthostatic Hypotension, and 8 of those are currently open to recruitment — roughly 47% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Orthostatic Hypotension shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 6 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Orthostatic Hypotension is led by Vanderbilt University Medical Center with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 17 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Orthostatic Hypotension?

PlainTrial tracks 17 US clinical trials for Orthostatic Hypotension, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Orthostatic Hypotension?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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