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ClinicalTrials.gov 8 recruiting now official registry

Bone Loss clinical trials

Every US clinical trial registered for Bone Loss — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

17 US clinical trials · 8 currently recruiting

The research picture

Bone Loss has 17 registered US clinical trials, 8 of them open to new participants right now — about 47% of the total.

8
recruiting participants now
47%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
2
top sponsor: Northwestern University

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 4 1,710 participants

LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women

Insud Pharma

NCT05303636

RECRUITING Phase 4 900 participants

Bone, Exercise, Alendronate, and Caloric Restriction

Wake Forest University Health Sciences

NCT05764733

RECRUITING 600 participants

An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects

AO Innovation Translation Center

NCT04112992

RECRUITING Phase 3 200 participants

Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery

Wake Forest University Health Sciences

NCT04922333

RECRUITING Phase 2 103 participants

Bone in CKD Alkali Response (BICARb Pilot Trial)

Albert Einstein College of Medicine

NCT05918029

RECRUITING 80 participants

Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk

Creighton University

NCT05701254

RECRUITING NA 80 participants

Lutein, Zeaxathin, and Fish Oil Supplementation

Texas A&M University

NCT06489873

RECRUITING NA 44 participants

Ridge Augmentation Using Allograft Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor

University of Alabama at Birmingham

NCT04954664

ACTIVE NOT RECRUITING 63 participants

CFTR Modulator Effects on Bone and Muscle in Adults With Cystic Fibrosis

Indiana University

NCT04206436

ACTIVE NOT RECRUITING NA 48 participants

TRE: Microbiome, Metabolic Health and Bone

Rutgers, The State University of New Jersey

NCT05548517

ACTIVE NOT RECRUITING 5 participants

Release Kinetics in PRF Versus GEM21S With and Without Bone Substitutes: An In Vitro Analysis

University of Alabama at Birmingham

NCT04964466

COMPLETED Phase 2 60 participants

Prevention of Bone Loss After Acute SCI by Zoledronic Acid

Northwestern University

NCT02325414

COMPLETED Phase 2 60 participants

Zoledronic Acid to Prevent Bone Loss During Androgen Deprivation Therapy for Prostate Cancer

Massachusetts General Hospital

NCT00181584

COMPLETED NA 42 participants

Effects of Dietary Protein on Musculoskeletal Health During Calorie Deficiency

United States Army Research Institute of Environmental Medicine

NCT01292395

COMPLETED 40 participants

Bone Loss After Laparoscopic Roux-en-Y Gastric Bypass

Gundersen Lutheran Medical Foundation

NCT00975013

COMPLETED Phase 2 25 participants

12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)

Northwestern University

NCT02025179

COMPLETED Phase 4 12 participants

Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)

Thomas J. Schnitzer

NCT00826228

Phase Distribution

PhaseTrial count
Phase 2 4
Phase 3 1
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bone Loss Trial Landscape

ClinicalTrials.gov lists 17 US studies indexed under Bone Loss, and 8 of those are currently open to recruitment — roughly 47% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Bone Loss shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Bone Loss is led by Northwestern University with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 17 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bone Loss?

PlainTrial tracks 17 US clinical trials for Bone Loss, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bone Loss?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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