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ClinicalTrials.gov 5 recruiting now early-phase tilt small index

Oral Cavity Cancer: early-phase trial registry

5 of 13 indexed Oral Cavity Cancer trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,315 of 28,707 conditions by registered trial count.

13 US clinical trials · 5 currently recruiting · #1,315 of 28,707 conditions by registered trial count

Oral Cavity Cancer: 13 US clinical trials tracked, 5 recruiting.

Oral Cavity Cancer is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 2 of these trials.

Enrollment posture brief

Registry condition oral-cavity-cancer

OPEN 5 | RECR 38% | LATE 1 | EARLY 5 | RANK #1315 | SPON 2

Nearest open-share peer: Anaplastic Oligodendroglioma (38% recruiting · 13 trials)

ACL Injury61.5%Acute Biphenotypic Leukemia46.2%Oral Cavity Cancer (this)38%Accidental Falls30.8%Actinic Keratoses23.1%
Open-enrollment share among volume-matched conditions near Oral Cavity Cancer

Oral Cavity Cancer lists 5 open slots (38% of 13 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Oral Cavity Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Oral Cavity Cancer is recruiting below its size-band peers.

    5 of 13 indexed trials (38.5%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Oral Cavity Cancer research.

    Memorial Sloan Kettering Cancer Center accounts for 2 of 13 trials (15.4%). 12 distinct sponsors appear on at least one study for this condition label.

  3. Most Oral Cavity Cancer trials plan to enrol fewer than 100 people.

    Median target enrolment is 75 among the 13 trials that report a genuine target (sentinel values excluded). 9 of those (69.2%) plan for fewer than 100 participants.

  4. Oral Cavity Cancer research is mostly interventional.

    10 interventional and 3 observational studies make up this index (76.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 24Phase 31

Open and recent trials

13 total, page 1 of 1

RECRUITING 1,500 participants

Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy

University Hospital Freiburg

NCT05337631

RECRUITING NA 532 participants

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Medical University of South Carolina

NCT05793151

RECRUITING Phase 2 75 participants

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07209189

RECRUITING Phase 2 40 participants

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Memorial Sloan Kettering Cancer Center

NCT07063212

RECRUITING NA 20 participants

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

University of Wisconsin, Madison

NCT07343596

ACTIVE NOT RECRUITING NA 40 participants

The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors

H. Lee Moffitt Cancer Center and Research Institute

NCT05798780

COMPLETED 115 participants

Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer

Mahesh Kudrimoti

NCT01084733

COMPLETED Phase 3 100 participants

Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

Covenant Health Cancer Center

NCT05369234

COMPLETED Phase 2 78 participants

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

University of California, San Diego

NCT03082534

COMPLETED 75 participants

Smoking Status and Body Image in Oral Cancer Patients

M.D. Anderson Cancer Center

NCT00412490

COMPLETED Phase 2 64 participants

Adaptive Radiotherapy for Head and Neck Cancer

Memorial Sloan Kettering Cancer Center

NCT03096808

COMPLETED Phase 1 59 participants

Pembrolizumab in Combination With CRT for LA-SCCHN

Sanford Health

NCT02586207

COMPLETED NA 20 participants

Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy

A.T. Still University of Health Sciences

NCT03267914

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 3 1

Named interventions

Most-linked intervention names on Oral Cavity Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Brush Other
1 trials
Tray Other
1 trials
Pembrolizumab, Cetuximab Drug
1 trials
Carafate Drug
1 trials
Salt and Baking soda rinse Combination
1 trials
Magic Mouthwash Combination
1 trials
100% Aloe Vera Juice Dietary supplement
1 trials
pembrolizumab (MK-3475) Drug
1 trials

US sites by state

Facility locations filed on Oral Cavity Cancer trials. A trial with sites in several states counts in each.

New York 3 trials
Texas 2 trials
New Jersey 2 trials
Missouri 2 trials
Maryland 2 trials
California 2 trials
Wisconsin 1 trials
Tennessee 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Oral Cavity Cancer page

13 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Oral Cavity Cancer condition card totals 13 registered trials; most-linked intervention Brush; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.