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ClinicalTrials.gov 5 recruiting now official registry

Oral Cavity Cancer clinical trials

5 of 13 indexed Oral Cavity Cancer trials are currently recruiting.

13 US clinical trials · 5 currently recruiting

Oral Cavity Cancer is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 2 of these trials.

The research picture

Oral Cavity Cancer has 13 registered US clinical trials, 5 of them open to new participants right now, about 38% of the total.

5
recruiting participants now
38%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 11Phase 24Phase 31

Active & Recent Trials

13 total, page 1 of 1

RECRUITING 1,500 participants

Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy

University Hospital Freiburg

NCT05337631

RECRUITING NA 532 participants

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Medical University of South Carolina

NCT05793151

RECRUITING Phase 2 75 participants

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07209189

RECRUITING Phase 2 40 participants

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Memorial Sloan Kettering Cancer Center

NCT07063212

RECRUITING NA 20 participants

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

University of Wisconsin, Madison

NCT07343596

ACTIVE NOT RECRUITING NA 40 participants

The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors

H. Lee Moffitt Cancer Center and Research Institute

NCT05798780

COMPLETED 115 participants

Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer

Mahesh Kudrimoti

NCT01084733

COMPLETED Phase 3 100 participants

Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

Covenant Health Cancer Center

NCT05369234

COMPLETED Phase 2 78 participants

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

University of California, San Diego

NCT03082534

COMPLETED 75 participants

Smoking Status and Body Image in Oral Cancer Patients

M.D. Anderson Cancer Center

NCT00412490

COMPLETED Phase 2 64 participants

Adaptive Radiotherapy for Head and Neck Cancer

Memorial Sloan Kettering Cancer Center

NCT03096808

COMPLETED Phase 1 59 participants

Pembrolizumab in Combination With CRT for LA-SCCHN

Sanford Health

NCT02586207

COMPLETED NA 20 participants

Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy

A.T. Still University of Health Sciences

NCT03267914

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Oral Cavity Cancer Trial Landscape

13 indexed Oral Cavity Cancer studies · 5 recruiting (38%).

Phase mix: 1 late (III/IV) vs 5 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (2 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Oral Cavity Cancer?

PlainTrial tracks 13 US clinical trials for Oral Cavity Cancer, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Oral Cavity Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.