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ClinicalTrials.gov 27 recruiting now official registry

Obesity and Overweight clinical trials

27 of 28 indexed Obesity and Overweight trials are currently recruiting.

28 US clinical trials · 27 currently recruiting

Obesity and Overweight is the subject of 28 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Dr. Christopher McGowan, running 2 of these trials.

The research picture

Obesity and Overweight has 28 registered US clinical trials, 27 of them open to new participants right now, about 96% of the total.

27
recruiting participants now
96%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Dr. Christopher McGowan
Phase 12Phase 24Phase 31

Active & Recent Trials

28 total, page 1 of 1

RECRUITING NA 6,200 participants

Advancing Biopsychosocial Care Training Initiative

Washington University School of Medicine

NCT07049861

RECRUITING Phase 3 3,500 participants

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Metsera, a wholly owned subsidiary of Pfizer

NCT07311850

RECRUITING NA 795 participants

CHIME: Comparing Health Interventions for Maternal Equity

Stanford University

NCT06724172

RECRUITING NA 290 participants

Comparision of Aerobic Exercise to Aerobic Plus Yoga Exercise for Weight Loss in Adults With Overweight or Obesity.

University of Kansas Medical Center

NCT06636773

RECRUITING NA 256 participants

FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

University of North Carolina, Chapel Hill

NCT06724406

RECRUITING 210 participants

Brain and Behavior Influences on Obesity Development From Infancy Through Childhood

Johns Hopkins University

NCT06861868

RECRUITING Phase 2 200 participants

A Mobile Intervention to Reduce Pain and Improve Health-III

Wake Forest University

NCT06623669

RECRUITING Phase 1 136 participants

A Phase 1 Study of WVE-007 in Adults Living With Overweight or Obesity

Wave Life Sciences

NCT06842186

RECRUITING Phase 2 105 participants

Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder

Johns Hopkins University

NCT06847399

RECRUITING 100 participants

Study of Patients Being Treated With Anti-obesity Medication

Texas Tech University

NCT06790160

RECRUITING NA 80 participants

A Study to Evaluate a Postbiotic in Supporting Weight Loss and Metabolic Health

ResBiotic Nutrition

NCT06911073

RECRUITING NA 60 participants

Weight Management Intervention in College: A Pilot

The Miriam Hospital

NCT06994923

RECRUITING NA 55 participants

New Mechanisms of Obesity

Yale University

NCT06768827

RECRUITING NA 50 participants

To Test Whether Time-restricted Eating Coupled With a Healthy Diet is Beneficial in Liver Cancer Patients

University of California, San Diego

NCT06824974

RECRUITING 50 participants

Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity

John Bauer

NCT06967389

RECRUITING NA 48 participants

FRESH-EATS Project

University of South Florida

NCT07053644

RECRUITING NA 44 participants

Metabolic Health, Bones and Nuts During Weight Loss in Adults

Rutgers, The State University of New Jersey

NCT06949280

RECRUITING Phase 2 42 participants

Tirzepatide for Alcohol Use Disorder

University of Southern California

NCT06994338

RECRUITING NA 40 participants

Muscle and Movement With Anti-Obesity Medications

University of Kansas Medical Center

NCT06645470

RECRUITING NA 38 participants

BrainWeighve App Feasibility Study

University of California, Los Angeles

NCT05530538

RECRUITING NA 36 participants

Effect of Watermelon on Gut and Cardiometabolic Health

Florida State University

NCT06588218

RECRUITING NA 30 participants

Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial

University of Alabama at Birmingham

NCT06976307

RECRUITING NA 24 participants

Metabotyping of Broccoli Microgreen in Obese Breast Cancer Survivors

University of Maryland, Baltimore

NCT07032545

RECRUITING NA 20 participants

MAINTAIN (Mucosal AblatIoN Therapy After INcretins)

Dr. Christopher McGowan

NCT06734312

RECRUITING NA 20 participants

Effects of Ultra Processed Food on Intestinal Energy Harvest

Columbia University

NCT06853288

RECRUITING Phase 2 12 participants

Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV

University of Hawaii

NCT06935838

RECRUITING NA 5 participants

REvision of VSG with Ablation of the Mucosa Procedure

Dr. Christopher McGowan

NCT06671119

ACTIVE NOT RECRUITING Phase 1 120 participants

A Study of MET233 in Individuals With Obesity or Overweight

Metsera, a wholly owned subsidiary of Pfizer

NCT07022977

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Obesity and Overweight Trial Landscape

28 indexed Obesity and Overweight studies · 27 recruiting (96%).

Phase mix: 1 late (III/IV) vs 6 early (I/II).

Top sponsor: Dr. Christopher McGowan (2 trials), 9 others listed. 28 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Obesity and Overweight?

PlainTrial tracks 28 US clinical trials for Obesity and Overweight, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Obesity and Overweight?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.