Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06847399 · ClinicalTrials.gov registry record · Phase 2
Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder
A Phase 2 study of Binge-Eating Disorder and Obesity and Overweight, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 105
- Enrollment target
- 1
- Study location
NCT06847399: Recruiting Phase 2 study of Binge-Eating Disorder and Obesity and Overweight, sponsored by Johns Hopkins University.
NCT06847399 is a Phase 2 study of Binge-Eating Disorder and Obesity and Overweight that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 105 participants, below the 1,141-participant average among 37 other Binge-Eating Disorder trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06847399, a Phase 2 study of Binge-Eating Disorder and Obesity and Overweight, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 105 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to assess the efficacy and safety of tirzepatide in adults with obesity and binge-eating disorder, comparing tirzepatide against placebo and lisdexamfetamine dimesylate. All participants will receive guided self-help cognitive behavioral therapy.
Primary Outcome
To compare tirzepatide maximum tolerated dose (MTD) versus placebo from randomization to week 52 for percent initial weight loss
Conditions Studied
Interventions
- DRUG Tirzepatide
- DRUG Lisdexamfetamine Dimesylate
- BEHAVIORAL Guided self-help cognitive behavioral therapy
- DRUG Placebo (oral)
- DRUG Placebo (injection)
Study Locations (1)
Maryland
- Johns Hopkins University - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2025-09-17 |
| Est. Completion | 2027-12-01 |
| Phase | Phase 2 |
What NCT06847399 shows while recruiting
NCT06847399 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, below the 1,141-participant average among 37 other Binge-Eating Disorder trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Binge-Eating Disorder appearing as the primary indexed condition, and to 5 interventions - of which Tirzepatide is the first listed.
NCT06847399 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06847399 about?
NCT06847399 is a clinical study titled "Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder". The purpose of this study is to assess the efficacy and safety of tirzepatide in adults with obesity and binge-eating disorder, comparing tirzepatide against placebo and lisdexamfetamine dimesylate. All participants will receive guided self-help cognitive behavioral therapy.
What is the current status of trial NCT06847399?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 105 participants. The study started on 2025-09-17. Estimated completion is 2027-12-01.
What conditions does trial NCT06847399 study?
This clinical trial studies the following conditions: Binge-Eating Disorder, Obesity and Overweight.
What interventions are being tested in trial NCT06847399?
The interventions under investigation include: Tirzepatide (DRUG), Lisdexamfetamine Dimesylate (DRUG), Guided self-help cognitive behavioral therapy (BEHAVIORAL), Placebo (oral) (DRUG), Placebo (injection) (DRUG).
Who is sponsoring clinical trial NCT06847399?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06847399 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Binge-Eating Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06847399's enrollment target sits among peer trials
105 14th of 37 higher than 24 of 37 other Binge-Eating Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Binge-Eating Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder
RECRUITING · Phase 2
-
Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy
COMPLETED · Phase 2
-
Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment
COMPLETED · Phase 2
-
Dasotraline Binge Eating Disorder Study
COMPLETED · Phase 2
-
Vortioxetine for Binge Eating Disorder
COMPLETED · Phase 2
-
Craving, Binge Eating and Obesity
COMPLETED · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03372317 · 105 participants
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
- NCT04253964 · 105 participants · Phase 2
Pilot Study of Performance Status 2 vs. Performance Status 0-1 Non-small Cell Lung Cancer Patients Treated With Chemo/Immunotherapy
- NCT04742452 · 105 participants · NA
Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears
- NCT04875429 · 105 participants · NA
Zenith® Fenestrated+ Clinical Study
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI