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NCT06847399 · ClinicalTrials.gov registry record · Phase 2

Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder

A Phase 2 study of Binge-Eating Disorder and Obesity and Overweight, sponsored by Johns Hopkins University.

Recruiting
Registry status
Phase 2
Development phase
105
Enrollment target
1
Study location

NCT06847399 is a Phase 2 study of Binge-Eating Disorder and Obesity and Overweight that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 105 participants, below the 1,141-participant average among 37 other Binge-Eating Disorder trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06847399, a Phase 2 study of Binge-Eating Disorder and Obesity and Overweight, is actively recruiting participants, sponsored by Johns Hopkins University.

RECRUITING
Registry status
Phase 2
Development phase
105 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to assess the efficacy and safety of tirzepatide in adults with obesity and binge-eating disorder, comparing tirzepatide against placebo and lisdexamfetamine dimesylate. All participants will receive guided self-help cognitive behavioral therapy.

Conditions Studied

Binge-Eating Disorder Obesity and Overweight

Interventions

  • DRUG Tirzepatide
  • DRUG Lisdexamfetamine Dimesylate
  • BEHAVIORAL Guided self-help cognitive behavioral therapy
  • DRUG Placebo (oral)
  • DRUG Placebo (injection)

Study Locations (1)

Maryland

  • Johns Hopkins University - Baltimore

Trial Details

FieldValue
Enrollment Target 105 participants
Start Date 2025-09-17
Est. Completion 2027-12-01
Phase Phase 2

Sponsor

Johns Hopkins University

1,448 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06847399

The ClinicalTrials.gov registry entry for NCT06847399 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 105 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,141-participant average among 37 other Binge-Eating Disorder trials with a reported enrollment target (91% lower). The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Binge-Eating Disorder appearing as the primary indexed condition, and to 5 interventions - of which Tirzepatide is the first listed.

NCT06847399 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.

Frequently Asked Questions

What is clinical trial NCT06847399 about?

NCT06847399 is a clinical study titled "Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder". The purpose of this study is to assess the efficacy and safety of tirzepatide in adults with obesity and binge-eating disorder, comparing tirzepatide against placebo and lisdexamfetamine dimesylate. All participants will receive guided self-help cognitive behavioral therapy.

What is the current status of trial NCT06847399?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 105 participants. The study started on 2025-09-17. Estimated completion is 2027-12-01.

What conditions does trial NCT06847399 study?

This clinical trial studies the following conditions: Binge-Eating Disorder, Obesity and Overweight.

What interventions are being tested in trial NCT06847399?

The interventions under investigation include: Tirzepatide (DRUG), Lisdexamfetamine Dimesylate (DRUG), Guided self-help cognitive behavioral therapy (BEHAVIORAL), Placebo (oral) (DRUG), Placebo (injection) (DRUG).

Who is sponsoring clinical trial NCT06847399?

This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06847399 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.