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ClinicalTrials.gov 203 recruiting now official registry

Non-Small Cell Lung Cancer clinical trials

203 of 450 indexed Non-Small Cell Lung Cancer trials are currently recruiting.

450 US clinical trials · 203 currently recruiting

Non-Small Cell Lung Cancer is the subject of 450 registered US clinical trials on ClinicalTrials.gov, 203 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 324 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 24 of these trials.

The research picture

Non-Small Cell Lung Cancer has 450 registered US clinical trials, 203 of them open to new participants right now, about 45% of the total.

203
recruiting participants now
45%
of trials open to enrollment
65
in Phase 3–4 (later-stage)
24
top sponsor: AstraZeneca
Phase 1201Phase 2123Phase 362Phase 43

Active & Recent Trials

450 total, page 8 of 9

COMPLETED Phase 1 306 participants

Pharmacokinetic and Safety Study of Lower Doses of Ceritinib Taken With a Low-fat Meal Versus 750 mg of Ceritinib in the Fasted State in Adult Patients With (ALK-positive) Metastatic Non-small Cell Lung Cancer (NSCLC)

Novartis Pharmaceuticals

NCT02299505

COMPLETED Phase 4 300 participants

Non-small Cell Lung Cancer Registry

Novartis Pharmaceuticals

NCT00099541

COMPLETED 276 participants

An Observational Pilot Study Evaluating the Feasibility of Conducting Genome-Wide Association Studies Utilizing Subject Provided Information in Subjects With Locally Recurrent or MBC, MCRC, MNSCLC, RGBM or MRCC Treated With Avastin (Bevacizumab) (InVite)

Genentech

NCT01598597

COMPLETED Phase 3 275 participants

Phase III of RRM1 & ERCC1 Directed Customized Chemotherapy for the Treatment of Patients With NSCLC

H. Lee Moffitt Cancer Center and Research Institute

NCT00499109

COMPLETED Phase 1 269 participants

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

Exelixis

NCT04925284

COMPLETED Phase 1 248 participants

Combination of RAD001 and Erlotinib in Patients With Advanced Non Small Cell Lung Cancer Previously Treated Only With Chemotherapy

Novartis Pharmaceuticals

NCT00456833

COMPLETED Phase 3 243 participants

Cisplatin/Etoposide/Radiotherapy +/- Consolidation Docetaxel in Advanced Stage III Non-Small Cell Lung Cancer

Nasser Hanna, M.D.

NCT00216125

COMPLETED NA 238 participants

Lung Cancer Surgery: Decisions Against Life Saving Care - The Intervention

University of North Carolina, Chapel Hill

NCT01687738

COMPLETED Phase 3 231 participants

LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib

Novartis Pharmaceuticals

NCT01828112

COMPLETED Phase 1 226 participants

Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

Celgene

NCT01177397

COMPLETED Phase 2 218 participants

First Line Chemotherapy Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)

Eli Lilly and Company

NCT00308750

COMPLETED Phase 1 215 participants

NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

NeoImmuneTech

NCT04332653

COMPLETED Phase 1 204 participants

Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors

BeiGene

NCT04215978

COMPLETED Phase 2 202 participants

Randomized, Double-Blind Trial of Erlotinib/Pazopanib or Erlotinib/Placebo in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer

SCRI Development Innovations

NCT01027598

COMPLETED Phase 1 191 participants

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)

Syndax Pharmaceuticals

NCT02437136

COMPLETED Phase 1 184 participants

Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma

Amgen

NCT00531284

COMPLETED Phase 2 180 participants

Study of LY2181308 in Combination With Docetaxel Versus Docetaxel in Patients With Non-Small Cell Lung Cancer

Eli Lilly and Company

NCT01107444

COMPLETED Phase 2 179 participants

A Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer

Hoffmann-La Roche

NCT05171777

COMPLETED Phase 2 172 participants

Trial of Poor Performance Status Patients (ToPPS)

SCRI Development Innovations

NCT00892710

COMPLETED Phase 2 167 participants

A Randomized Phase 2 Study of Erlotinib + ARQ 197 Versus Erlotinib + Placebo in Previously Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT00777309

COMPLETED Phase 2 162 participants

Study of Vandetanib Combined With Chemotherapy to Treat Advanced Non-small Cell Lung Cancer

PrECOG

NCT00687297

COMPLETED Phase 2 155 participants

Phase 2 Study of VELCADE Alone or VELCADE® Plus Docetaxel in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer

Millennium Pharmaceuticals

NCT00051974

COMPLETED Phase 2 129 participants

Safety Study of Nivolumab to Treat Advanced or Metastatic Non-small Cell Lung Cancer

Bristol-Myers Squibb

NCT03090737

COMPLETED Phase 1 116 participants

Safety and Tolerability Study of ISIS EIF4E Rx in Combination With Carboplatin and Paclitaxel

Ionis Pharmaceuticals

NCT01234038

COMPLETED 103 participants

Molecular and Diagnostic Classification of Non-Small Cell Lung Cancer From Fine Needle Aspirates

Wake Forest University Health Sciences

NCT01630122

COMPLETED Phase 3 103 participants

Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients With Stage II-III Non-Small Cell Lung Cancer

University of Texas Southwestern Medical Center

NCT01459497

COMPLETED Phase 1 100 participants

Trial of Bi-shRNA-furin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer

Gradalis

NCT01061840

COMPLETED Phase 2 98 participants

An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer

Pfizer

NCT03915951

COMPLETED Phase 2 90 participants

Efficacy/Safety of Imprime PGG® Injection With Bevacizumab and Paclitaxel/Carboplatin in Patients With Untreated Advanced Non-Small Cell Lung Cancer (NSCLC)

HiberCell

NCT00874107

COMPLETED Phase 2 88 participants

AZD6244 in Combination With Docetaxel Versus Docetaxel Alone in KRAS Mutation Positive NSCLC Patients

AstraZeneca

NCT00890825

COMPLETED Phase 1 85 participants

A Study of Ramucirumab (LY3009806) Plus MEDI4736 in Participants With Advanced Gastrointestinal or Thoracic Malignancies

Eli Lilly and Company

NCT02572687

COMPLETED Phase 2 85 participants

Inositol in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia

National Cancer Institute (NCI)

NCT00783705

COMPLETED Phase 2 85 participants

CAB-AXL-ADC Safety and Efficacy Study in Adults With NSCLC

BioAtla

NCT04681131

COMPLETED Phase 2 84 participants

Erlotinib in Women With Previously Untreated Adenocarcinoma of the Lung

Pasi A. Janne, MD, PhD

NCT00137839

COMPLETED Phase 2 82 participants

Ixabepilone and Carboplatin +/- Bevacizumab in Advanced Non-Small-Cell Lung Cancer

SCRI Development Innovations

NCT00741988

COMPLETED Phase 1 80 participants

Safety Study of XL765 (SAR245409) in Combination With Erlotinib in Adults With Solid Tumors

Sanofi

NCT00777699

COMPLETED Phase 2 76 participants

Priming Immunotherapy in Advanced Disease With Radiation

John L. Villano, MD, PhD

NCT03313804

COMPLETED Phase 1 75 participants

Trial of ABI-007 Administered Weekly in Chemotherapy Naive Patients With Advanced Non-Small Cell Lung Cancer

Celgene Corporation

NCT00073723

COMPLETED 75 participants

Oncology Research Information Exchange Network (ORIEN) Lung Cancer Study

H. Lee Moffitt Cancer Center and Research Institute

NCT02803333

COMPLETED Phase 2 70 participants

Ispinesib In Patients With Advanced Or Metastatic Non-Small Cell Lung Cancer

GlaxoSmithKline

NCT00085813

COMPLETED Phase 1 69 participants

Combination of RAD001 With Carboplatin, Paclitaxel and Bevacizumab in Non-small-cell Lung Cancer (NSCLC) Patients

Novartis Pharmaceuticals

NCT00457119

COMPLETED Phase 2 66 participants

Study Tests The Safety And Effectiveness Of SU011248 In Patients With Non-Small Cell Lung Cancer Having Brain Metastases

Pfizer

NCT00372775

COMPLETED Phase 2 65 participants

MK-3475 in Melanoma and NSCLC Patients With Brain Metastases

Yale University

NCT02085070

COMPLETED Phase 1 64 participants

Oral STAT3 Inhibitor, TTI-101, in Patients with Advanced Cancers

Tvardi Therapeutics, Incorporated

NCT03195699

COMPLETED Phase 2 63 participants

Dose/ Schedule Finding Trial of Romiplostim for Chemotherapy-Induced Thrombocytopenia (CIT) in Non-Small Cell Lung Cancer (NSCLC)

Amgen

NCT00413283

COMPLETED Phase 2 63 participants

Sunitinib Non Small Cell Lung Cancer Patients Over 70

US Oncology Research

NCT00864721

COMPLETED Phase 2 55 participants

Study of XL647 in Subjects With Non-Small-Cell Lung Cancer

Kadmon Corporation

NCT00364780

COMPLETED Phase 1 54 participants

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Incyte Corporation

NCT04580485

COMPLETED Phase 2 53 participants

Cetuximab and Vinorelbine in Elderly Subjects With Lung Cancer

Dana-Farber Cancer Institute

NCT00165334

COMPLETED Phase 1 52 participants

A Phase 1b Study of Atezolizumab in Combination With Erlotinib or Alectinib in Participants With Non-Small Cell Lung Cancer (NSCLC)

Hoffmann-La Roche

NCT02013219

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Phase Distribution

PhaseTrial count
Phase 1 201
Phase 2 123
Phase 3 62
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Small Cell Lung Cancer Trial Landscape

450 indexed Non-Small Cell Lung Cancer studies · 203 recruiting (45%).

Phase mix: 65 late (III/IV) vs 324 early (I/II).

Top sponsor: AstraZeneca (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Small Cell Lung Cancer?

PlainTrial tracks 450 US clinical trials for Non-Small Cell Lung Cancer, of which 203 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.