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Randomized, Double-Blind Trial of Erlotinib/Pazopanib or Erlotinib/Placebo in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer
NCT01027598 · View on ClinicalTrials.gov ↗
Study Summary
This randomized, placebo-controlled, Phase II trial will compare the combination of erlotinib with pazopanib (providing concurrent EGFR and VEGFR inhibition) with erlotinib alone in the second- or third-line treatment of patients with advanced NSCLC. This study will be conducted though the Sarah Cannon Research Consortium, a community-based clinical trial network.
Conditions Studied
Interventions
- DRUG Pazopanib
- DRUG Erlotinib
Study Locations (8)
Tennessee
- Chattanooga Oncology Hematology Associates — Chattanooga
- Family Cancer Center — Collerville
- Tennessee Oncology, PLLC — Nashville
Florida
- Florida Cancer Specialists — Fort Myers
Georgia
- Suburban Hem Onc — Lawrenceville
Ohio
- Oncology Hematology Care — Cincinnati
South Carolina
- South Carolina Oncology Associates, PA — Columbia
Virginia
- Virginia Cancer Institute — Richmond
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 202 participants |
| Start Date | 2010-01 |
| Est. Completion | 2014-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01027598
The ClinicalTrials.gov registry entry for NCT01027598 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 202 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is SCRI Development Innovations, which has 63 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Non Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Pazopanib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01027598 reports 8 study locations spanning 6 distinct geographic areas — top geographies include Tennessee, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01027598 about?
NCT01027598 is a clinical study titled "Randomized, Double-Blind Trial of Erlotinib/Pazopanib or Erlotinib/Placebo in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer". This randomized, placebo-controlled, Phase II trial will compare the combination of erlotinib with pazopanib (providing concurrent EGFR and VEGFR inhibition) with erlotinib alone in the second- or third-line treatment of patients with advanced NSCLC. This study will be conducted though the Sarah Can...
What is the current status of trial NCT01027598?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 202 participants. The study started on 2010-01. Estimated completion is 2014-06.
What conditions does trial NCT01027598 study?
This clinical trial studies the following conditions: Non Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01027598?
The interventions under investigation include: Pazopanib (DRUG), Erlotinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01027598?
This trial is sponsored by SCRI Development Innovations, which has 63 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01027598 being conducted?
This trial has 8 study locations across Florida, Georgia, Ohio, South Carolina, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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