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ClinicalTrials.gov 203 recruiting now official registry

Non-Small Cell Lung Cancer clinical trials

203 of 450 indexed Non-Small Cell Lung Cancer trials are currently recruiting.

450 US clinical trials · 203 currently recruiting

Non-Small Cell Lung Cancer is the subject of 450 registered US clinical trials on ClinicalTrials.gov, 203 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 324 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 24 of these trials.

The research picture

Non-Small Cell Lung Cancer has 450 registered US clinical trials, 203 of them open to new participants right now, about 45% of the total.

203
recruiting participants now
45%
of trials open to enrollment
65
in Phase 3–4 (later-stage)
24
top sponsor: AstraZeneca
Phase 1201Phase 2123Phase 362Phase 43

Active & Recent Trials

450 total, page 9 of 9

COMPLETED NA 50 participants

Understanding Evidence-Based Practice Patterns in Advanced NSCLC

Carevive Systems

NCT03107156

COMPLETED 49 participants

Registry Study of Thoracic Reirradiation for Non-Small Cell Lung Cancer (NSCLC) Utilizing Proton Beam Therapy or Intensity Modulated Radiation Therapy

M.D. Anderson Cancer Center

NCT01808677

COMPLETED Phase 1 48 participants

A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers

Merrimack Pharmaceuticals

NCT01451632

COMPLETED Phase 1 48 participants

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Arcus Biosciences

NCT03629756

COMPLETED Phase 2 44 participants

Phase II Study of Docetaxel + ZD1839 in Elderly Patients With Non-Small Cell Lung Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT00231465

COMPLETED NA 44 participants

Phase II Study of Stereotactic Body Radiation Therapy Using Tomotherapy for Tumors of the Lung

New Mexico Cancer Research Alliance

NCT00832780

COMPLETED Phase 2 44 participants

Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT00871923

COMPLETED Phase 1 43 participants

A Phase I/IB Trial of MEK162 in Combination With Erlotinib in NSCLC Harboring KRAS or EGFR Mutation

H. Lee Moffitt Cancer Center and Research Institute

NCT01859026

COMPLETED Phase 2 43 participants

Avastin/Docetaxel/Carboplatin in Non-Small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT00271505

COMPLETED Phase 3 42 participants

Study to Evaluate SID 530 Compared to Taxotere

SK Chemicals Co.

NCT00931008

COMPLETED Phase 2 42 participants

Bortezomib in Treating Patients With Stage IIIB or Stage IV Lung Cancer

National Cancer Institute (NCI)

NCT00118144

COMPLETED Phase 1 41 participants

Radiation Therapy to Relieve Symptoms in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Memorial Sloan Kettering Cancer Center

NCT04384146

COMPLETED NA 41 participants

Effects of Essential Amino Acid Intake on Net Protein Synthesis in Weight-losing Non-small Cell Lung Cancer Patients

Texas A&M University

NCT01172314

COMPLETED 40 participants

Functional Lung Imaging With DECT and 4DCT

Abramson Cancer Center at Penn Medicine

NCT04702607

COMPLETED 40 participants

Comprehensive Genomic Analysis in Tissue and Blood Samples From Young Patients With Lung Cancer

University of Southern California

NCT02273336

COMPLETED Phase 2 40 participants

Docetaxel and Gemcitabine With Filgrastim-SD/01 Support in Patients With Advanced Non-Small Cell Lung Carcinoma

Schwartzberg, Lee, M.D.

NCT00050674

COMPLETED Phase 1 39 participants

Stereotactic Body Radiation Therapy for Inoperable Locally-advanced Non-small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT01899989

COMPLETED Phase 1 38 participants

A First in Human, Dose Escalation Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors

Jacobio Pharmaceuticals Co.

NCT03518554

COMPLETED Phase 1 38 participants

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Tempest Therapeutics

NCT03829436

COMPLETED Phase 2 38 participants

NAP in Combination With Docetaxel Following Obinutuzumab Pretreatment in Subjects With Checkpoint Inhibitor Pretreated Advanced or Metastatic NSCLC

NeoTX Therapeutics

NCT04880863

COMPLETED Phase 2 36 participants

Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases

Kadmon Corporation

NCT02616393

COMPLETED Phase 1 35 participants

Pembrolizumab + Imprime PGG for Metastatic Non-small Cell Lung Cancer After Progression on First-Line Therapy: Big Ten Cancer Research Consortium BTCRC-LUN15-017

Lawrence Feldman, MD

NCT03003468

COMPLETED Phase 2 32 participants

Stereotactic Radiosurgery or Other Local Ablation Then Erlotinib in Epidermal Growth Factor Receptor (EGFR)

UNC Lineberger Comprehensive Cancer Center

NCT01573702

COMPLETED Phase 2 30 participants

A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer

OncoNano Medicine

NCT03735680

COMPLETED Phase 1 30 participants

A Study of Intravenous XMT-1001 in Patients With Advanced Solid Tumors

Mersana Therapeutics

NCT00455052

COMPLETED Phase 1 30 participants

G1T38, a CDK 4/6 Inhibitor, in Combination With Osimertinib in EGFR-Mutant Non-Small Cell Lung Cancer

G1 Therapeutics

NCT03455829

COMPLETED Phase 1 29 participants

A Study of a Personalized Neoantigen Cancer Vaccine

Gritstone bio

NCT03639714

COMPLETED Phase 1 27 participants

Safety Study of MKC-1 Combined With Pemetrexed to Treat Advanced Cancer and Non-Small Cell Lung Cancer

CASI Pharmaceuticals

NCT00408226

COMPLETED Phase 1 27 participants

Erlotinib Is Being Studied With Or Without An Investigational Drug, PF-02341066, In Patients With Lung Cancer

Pfizer

NCT00965731

COMPLETED Phase 1 26 participants

Early Prediction of Therapeutic Response to Targeted Therapy in Stage IIIB/IV or Recurrent Lung Cancer Patients

University of Utah

NCT00708448

COMPLETED Phase 1 23 participants

M1231 in Participants With Solid Tumors

EMD Serono Research & Development Institute

NCT04695847

COMPLETED Phase 2 22 participants

Imatinib Mesylate and Docetaxel in Non-Small Cell Lung Cancer (NSCLC)

M.D. Anderson Cancer Center

NCT01083589

COMPLETED Phase 1 22 participants

Phase Ib Study of LDK378 and AUY922 in ALK-rearranged Non-small Cell Lung Cancer

Novartis Pharmaceuticals

NCT01772797

COMPLETED Phase 1 21 participants

Phase I Study of Induction Therapy With VELCADE and Vorinostat in Patients With Surgically Resectable Non-Small Cell Lung Cancer

University of Virginia

NCT00731952

COMPLETED Phase 1 19 participants

A Phase I Study of SUNITINIB and Rapamycin in Advanced Non-Small Cell Lung Cancer (NSCLC)

Washington University School of Medicine

NCT00555256

COMPLETED NA 19 participants

Dignity Therapy/Life Plan in Patients With Pancreatic or Advanced Lung Cancer

Mayo Clinic

NCT02132325

COMPLETED 18 participants

Pulmonary Physiology and Systemic Inflammatory in EO Pulmonary Events With Brigatinib Use in NSCLC and Other Diseases

University of Colorado, Denver

NCT03389399

COMPLETED Phase 1 18 participants

Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia

Pfizer

NCT04803305

COMPLETED 15 participants

Perceptions on Expected Outcomes of Immunotherapy in Advanced Cancer Patients With Poor Performance Status

M.D. Anderson Cancer Center

NCT05634551

COMPLETED NA 14 participants

Feasibility of a Hybrid Delivery of Home-based Cluster Set Resistance Training in Lung Cancer

University of South Carolina

NCT05014035

COMPLETED Phase 1 13 participants

Study of Mogamulizumab + Docetaxel in Subjects With Non-small Cell Lung Cancer

Kyowa Kirin

NCT02358473

COMPLETED Phase 1 12 participants

IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors

H. Lee Moffitt Cancer Center and Research Institute

NCT03758781

COMPLETED Early Phase 1 12 participants

A Pilot Study of MPDL3280A and HIGRT in Metastatic NSCLC

University of Michigan Rogel Cancer Center

NCT02463994

COMPLETED Phase 1 11 participants

GEN-001 (Live Biotherapeutic Product) and Avelumab Combination Study for Patients With Solid Tumors Who Have Progressed on Anti-PD-(L)1 Therapy

Genome & Company

NCT04601402

COMPLETED Phase 1 11 participants

Lung Cancer With Copanlisib and Durvalumab

Zhonglin Hao

NCT04895579

COMPLETED Phase 2 9 participants

Erlotinib and Chemotherapy for Patients With Stage IB-IIIA NSCLC With EGFR Mutations (ECON)

Memorial Sloan Kettering Cancer Center

NCT00577707

COMPLETED Phase 1 9 participants

Study of S-3304 in Patients With Locally Advanced Non-Small Cell Lung Cancer

Shionogi

NCT00078390

COMPLETED Phase 1 6 participants

Intratumoral Cisplatin for Resectable NSCLC

University of Vermont

NCT04809103

COMPLETED Phase 1 6 participants

Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC

Case Comprehensive Cancer Center

NCT03535363

COMPLETED Phase 2 4 participants

Adjuvant Cisplatin and Docetaxel in Non Small Cell Lung Cancer

University of Wisconsin, Madison

NCT00582634

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Phase Distribution

PhaseTrial count
Phase 1 201
Phase 2 123
Phase 3 62
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Small Cell Lung Cancer Trial Landscape

450 indexed Non-Small Cell Lung Cancer studies · 203 recruiting (45%).

Phase mix: 65 late (III/IV) vs 324 early (I/II).

Top sponsor: AstraZeneca (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Small Cell Lung Cancer?

PlainTrial tracks 450 US clinical trials for Non-Small Cell Lung Cancer, of which 203 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.