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ClinicalTrials.gov 58 recruiting now official registry

Non-Hodgkin Lymphoma clinical trials

58 of 105 indexed Non-Hodgkin Lymphoma trials are currently recruiting.

105 US clinical trials · 58 currently recruiting

Non-Hodgkin Lymphoma is the subject of 105 registered US clinical trials on ClinicalTrials.gov, 58 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 85 in Phase 1-2 (earlier-stage). The most active sponsor is Baylor College of Medicine, running 7 of these trials.

The research picture

Non-Hodgkin Lymphoma has 105 registered US clinical trials, 58 of them open to new participants right now, about 55% of the total.

58
recruiting participants now
55%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
7
top sponsor: Baylor College of Medicine
Phase 166Phase 219Phase 34Phase 42

Active & Recent Trials

105 total, page 2 of 3

RECRUITING Phase 1 22 participants

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

University of Wisconsin, Madison

NCT02508038

RECRUITING Phase 1 21 participants

T-Cell Therapy (EB103) in Adults With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)

Estrella Biopharma

NCT06343311

RECRUITING Phase 1 20 participants

Study of Cytokine Release Syndrome Prophylaxis and Treatment With Siltuximab Prior to Epcoritamab

Taylor Brooks

NCT06447376

RECRUITING Phase 1 20 participants

Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Cel

Stanford University

NCT05794958

RECRUITING Phase 2 20 participants

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

Mitchell Cairo

NCT04099966

RECRUITING 20 participants

Improving Communication and Building a Stronger Medical Home Among Spanish-speaking Families

University of Colorado, Denver

NCT05425992

RECRUITING Phase 1 12 participants

LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

Medical College of Wisconsin

NCT05990465

RECRUITING Early Phase 1 8 participants

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06398457

ACTIVE NOT RECRUITING NA 603 participants

Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health

University of Alabama at Birmingham

NCT04000880

ACTIVE NOT RECRUITING Phase 2 503 participants

Methionine PET/CT Studies In Patients With Cancer

St. Jude Children's Research Hospital

NCT00840047

ACTIVE NOT RECRUITING 350 participants

Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study

City of Hope Medical Center

NCT04537871

ACTIVE NOT RECRUITING Phase 2 320 participants

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab Monotherapy in Participants With Select B-Cell Malignancies

Genentech

NCT05207670

ACTIVE NOT RECRUITING Phase 3 299 participants

Managing Pain and Symptom Burden Caused by Chemotherapy in People With Myeloma or Lymphoma

Memorial Sloan Kettering Cancer Center

NCT04459416

ACTIVE NOT RECRUITING Phase 3 208 participants

A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

Hoffmann-La Roche

NCT05171647

ACTIVE NOT RECRUITING Phase 1 113 participants

Study of Acalabrutinib Alone or in Combination Therapy in Subjects With B-cell Non-Hodgkin Lymphoma

Acerta Pharma

NCT02180711

ACTIVE NOT RECRUITING Phase 1 100 participants

A Phase 1b/2 Multisite Dose-finding and Expansion Study of WTX-330 in Adult Patients With Selected Advanced or Metastatic Solid Tumors or Lymphoma

Werewolf Therapeutics

NCT06939283

ACTIVE NOT RECRUITING Phase 1 100 participants

DS-3201b in Participants With Lymphomas

Daiichi Sankyo Co.

NCT02732275

ACTIVE NOT RECRUITING Phase 1 72 participants

huCART19-IL18 in CD19+ Cancers

University of Pennsylvania

NCT04684563

ACTIVE NOT RECRUITING Phase 1 45 participants

AB-101 as Monotherapy and With Immunotherapy in Patients With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Artiva Biotherapeutics

NCT04673617

ACTIVE NOT RECRUITING Phase 1 43 participants

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

University of Michigan Rogel Cancer Center

NCT03842696

ACTIVE NOT RECRUITING Phase 1 42 participants

Duvelisib Following Chimeric Antigen Receptor T-Cell Therapy

Washington University School of Medicine

NCT05044039

ACTIVE NOT RECRUITING Phase 1 38 participants

Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL)

Baylor College of Medicine

NCT02287311

ACTIVE NOT RECRUITING Phase 1 36 participants

Administration of TAA-Specific CTLs; Hodgkin or Non-Hodgkin Lymphoma; TACTAL

Baylor College of Medicine

NCT01333046

ACTIVE NOT RECRUITING Phase 1 35 participants

Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

Roswell Park Cancer Institute

NCT03192397

ACTIVE NOT RECRUITING Phase 1 31 participants

AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Non Hodgkin Lymphoma

Benjamin Tomlinson

NCT03434769

ACTIVE NOT RECRUITING NA 30 participants

Radiation Dose Study for Relapsed/Refractory Hodgkin/Non-Hodgkin Lymphoma

University of Chicago

NCT05019976

ACTIVE NOT RECRUITING Phase 1 25 participants

Venetoclax in Combination With BEAM Conditioning Regimen for ASCT in Non-Hodgkin Lymphoma

Case Comprehensive Cancer Center

NCT03713580

ACTIVE NOT RECRUITING Phase 1 21 participants

Evaluate the Safety of UF-KURE19 Cells in Non-Hodgkin Lymphomas

David Wald

NCT05400109

ACTIVE NOT RECRUITING Phase 1 20 participants

A Study of Radiation Therapy Before CAR T Cell Therapy for People With B Cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT05574114

ACTIVE NOT RECRUITING Phase 1 18 participants

Human AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Lymphoid Malignancies

Benjamin Tomlinson

NCT04732845

ACTIVE NOT RECRUITING Phase 1 17 participants

Study of the Adverse Events and Change in Disease State of Pediatric Participants (and Young Adults Between the Ages of 18-25) With Relapsed/Refractory Aggressive Mature B-cell Neoplasms Receiving Subcutaneous (SC) Injections of Epcoritamab

Genmab

NCT05206357

ACTIVE NOT RECRUITING Phase 1 16 participants

Study Evaluating SC291 in Subjects With r/r B-cell Malignancies (ARDENT)

Sana Biotechnology

NCT05878184

ACTIVE NOT RECRUITING Phase 1 15 participants

Administration of Donor T Cells With the Caspase-9 Suicide Gene

Baylor College of Medicine

NCT01494103

ACTIVE NOT RECRUITING Phase 1 12 participants

A Rollover Study of CC-122

Bristol-Myers Squibb

NCT05688475

ACTIVE NOT RECRUITING Phase 2 6 participants

RADVAX™ for Relapsed/Refractory Non-Hodgkin Lymphoma: A Phase II Trial of Pembrolizumab + Low Dose Radiotherapy

Abramson Cancer Center at Penn Medicine

NCT04827862

COMPLETED NA 600 participants

Assessing Effectiveness and Implementation of an EHR Tool to Assess Heart Health Among Survivors

Wake Forest University Health Sciences

NCT03935282

COMPLETED Phase 1 222 participants

A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma

AbbVie

NCT01328626

COMPLETED 174 participants

Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma

Children's Oncology Group

NCT01000753

COMPLETED Phase 1 111 participants

A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL

Hoffmann-La Roche

NCT03467373

COMPLETED Phase 2 92 participants

Study of Fc-Optimized Anti-CD19 Antibody (MOR00208) to Treat Non-Hodgkin's Lymphoma (NHL)

MorphoSys

NCT01685008

COMPLETED Phase 1 74 participants

LMP-specific T-cells for Patients With Relapsed EBV-positive Lymphoma

Baylor College of Medicine

NCT00062868

COMPLETED Phase 1 57 participants

Pralatrexate + Romidepsin in Relapsed/Refractory Lymphoid Malignancies

Jennifer Amengual

NCT01947140

COMPLETED Phase 1 55 participants

Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Washington University School of Medicine

NCT03755414

COMPLETED Phase 2 42 participants

Mosunetuzumab With or Without Polatuzumab Vedotin and Obinutuzumab for the Treatment of Untreated Indolent B-Cell Non-Hodgkin Lymphoma

University of Washington

NCT05169658

COMPLETED NA 40 participants

Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

University of Virginia

NCT04629430

COMPLETED Phase 1 39 participants

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

Masonic Cancer Center, University of Minnesota

NCT03019666

COMPLETED Phase 1 23 participants

Safety Study of CAT-8015 to Treat Advanced B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia (NHL or CLL)

MedImmune

NCT01030536

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 1 14 participants

A Study to Investigate the Effects of Ketoconazole on LBH589 in Patients With Advanced Solid Tumors

Novartis Pharmaceuticals

NCT00503451

COMPLETED Phase 1 14 participants

Duvelisib in Combination With BMS-986345 in Lymphoid Malignancy

H. Lee Moffitt Cancer Center and Research Institute

NCT05065866

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Phase Distribution

PhaseTrial count
Phase 1 66
Phase 2 19
Phase 3 4
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Hodgkin Lymphoma Trial Landscape

105 indexed Non-Hodgkin Lymphoma studies · 58 recruiting (55%).

Phase mix: 6 late (III/IV) vs 85 early (I/II).

Top sponsor: Baylor College of Medicine (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Hodgkin Lymphoma?

PlainTrial tracks 105 US clinical trials for Non-Hodgkin Lymphoma, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Hodgkin Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.