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NCT05574114 · ClinicalTrials.gov registry record · Phase 1
A Study of Radiation Therapy Before CAR T Cell Therapy for People With B Cell Lymphoma
A Phase 1 study of Non-Hodgkin Lymphoma and Non-Hodgkin's Lymphoma, Relapsed, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 7
- Study locations
NCT05574114: Active Phase 1 study of Non-Hodgkin Lymphoma and Non-Hodgkin's Lymphoma, Relapsed, sponsored by Memorial Sloan Kettering Cancer Center.
NCT05574114 is a Phase 1 study of Non-Hodgkin Lymphoma and Non-Hodgkin's Lymphoma, Relapsed that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 20 participants, below the 168-participant average among 106 other Non-Hodgkin Lymphoma trials with a reported enrollment target (88% lower). The trial reports 7 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05574114, a Phase 1 study of Non-Hodgkin Lymphoma and Non-Hodgkin's Lymphoma, Relapsed, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 7
- Study locations
Study Summary
The purpose of this study is to test whether radiation therapy given before standard CAR T cell therapy is a safe and effective treatment for people with relapsed and refractory B cell lymphoma. The researchers will also study whether radiation therapy used in this study is a practical treatment option before standard CAR T cell therapy.
Primary Outcome
Reporting of toxicities will be based on Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 except for CRS and ICANS which will be evaluated using ASTCT Consensus grading.
Conditions Studied
Interventions
- DRUG Conditioning chemotherapy
- RADIATION Bridging radiotherapy (BRT)
- BIOLOGICAL CAR T-cell product
Study Locations (7)
New York
- Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) - Harrison
- Memorial Sloan Kettering Cancer Center - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) - Uniondale
New Jersey
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-10-05 |
| Est. Completion | 2026-10 |
| Phase | Phase 1 |
What the registry record for NCT05574114 still lists
NCT05574114 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 168-participant average among 106 other Non-Hodgkin Lymphoma trials with a reported enrollment target (88% lower).
The record links to 3 conditions, with Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 3 interventions - of which Conditioning chemotherapy is the first listed.
NCT05574114 lists 7 locations in 2 states (New York, New Jersey).
Frequently Asked Questions
What is clinical trial NCT05574114 about?
NCT05574114 is a clinical study titled "A Study of Radiation Therapy Before CAR T Cell Therapy for People With B Cell Lymphoma". The purpose of this study is to test whether radiation therapy given before standard CAR T cell therapy is a safe and effective treatment for people with relapsed and refractory B cell lymphoma. The researchers will also study whether radiation therapy used in this study is a practical treatment opt...
What is the current status of trial NCT05574114?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2022-10-05. Estimated completion is 2026-10.
What conditions does trial NCT05574114 study?
This clinical trial studies the following conditions: Non-Hodgkin Lymphoma, Non-Hodgkin's Lymphoma, Relapsed, Non-Hodgkin's Lymphoma Refractory.
What interventions are being tested in trial NCT05574114?
The interventions under investigation include: Conditioning chemotherapy (DRUG), Bridging radiotherapy (BRT) (RADIATION), CAR T-cell product (BIOLOGICAL).
Who is sponsoring clinical trial NCT05574114?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05574114 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Non-Hodgkin Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05574114's enrollment target sits among peer trials
20 88th of 106 higher than 15 of 106 other Non-Hodgkin Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Hodgkin Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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