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RECRUITING Phase 1

A Study of Avutometinib for People With Solid Tumor Cancers

NCT06104488 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to find out whether avutometinib is a safe treatment for advanced or recurrent solid tumor cancers in children and young adults. Researchers will look for the highest dose of avutometinib that is safe and cause few or mild side effects.

Interventions

  • DRUG Avutometinib

Study Locations (2)

Georgia

  • Children's Healthcare of Atlanta (Data Collection Only) — Atlanta

New York

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York

Trial Details

FieldValue
Enrollment Target 23 participants
Start Date 2023-10-20
Est. Completion 2029-10-20
Phase Phase 1

Sponsor

Memorial Sloan Kettering Cancer Center

2,280 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06104488

The ClinicalTrials.gov registry entry for NCT06104488 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 23 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Memorial Sloan Kettering Cancer Center, which has 2,280 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Neuroblastoma appearing as the primary indexed condition, and to 1 intervention — of which Avutometinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06104488 reports 2 study locations spanning 2 distinct geographic areas — top geographies include Georgia, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06104488 about?

NCT06104488 is a clinical study titled "A Study of Avutometinib for People With Solid Tumor Cancers". The purpose of this study is to find out whether avutometinib is a safe treatment for advanced or recurrent solid tumor cancers in children and young adults. Researchers will look for the highest dose of avutometinib that is safe and cause few or mild side effects.

What is the current status of trial NCT06104488?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2023-10-20. Estimated completion is 2029-10-20.

What conditions does trial NCT06104488 study?

This clinical trial studies the following conditions: Neuroblastoma, Refractory Cancer, Low-grade Glioma, Plexiform Neurofibroma, NF1. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06104488?

The interventions under investigation include: Avutometinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06104488?

This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 2,280 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06104488 being conducted?

This trial has 2 study locations across Georgia, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial