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NCT06075524 · ClinicalTrials.gov registry record
Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types
A clinical trial of Metastatic Malignant Solid Neoplasm and Metastatic Melanoma, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- 500
- Enrollment target
- 1
- Study location
NCT06075524: Recruiting study of Metastatic Malignant Solid Neoplasm and Metastatic Melanoma, sponsored by Mayo Clinic.
NCT06075524 is a study of Metastatic Malignant Solid Neoplasm and Metastatic Melanoma that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 500 participants, above the 201-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (149% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06075524, a study of Metastatic Malignant Solid Neoplasm and Metastatic Melanoma, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- 500 participants
- Enrollment target
- 1
- Study location
Study Summary
This study explores the role of T cells in monitoring disease status and response during anti-PD-1/PD-L1 treatment in patients with melanoma, lung and other cancer types. Measuring levels of specific targets such as Bim and soluble PD-L1 during therapy may help track treatment resistance and clinical outcomes. This information may also help researchers determine why some people with melanoma, lung and other cancer types respond to PD-1/PD-L1 treatment and others do not.
Primary Outcome
Will be assessed by serial measurements of Bim levels in tumor-reactive CD8+ T cells from the peripheral blood of patients with advanced cancer undergoing therapy with an anti-PD-1 monoclonal antibody and correlate them with clinical outcome.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- OTHER Electronic Health Record Review
Study Locations (1)
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2015-06-15 |
| Est. Completion | 2026-12-31 |
What NCT06075524 shows while recruiting
NCT06075524 is an observational study that tracks outcomes without assigning an intervention. The registered 500 participants enrollment target is mid-sized for trials with a published cap, above the 201-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (149% higher).
The record links to 10 conditions, with Metastatic Malignant Solid Neoplasm appearing as the primary indexed condition, and to 2 interventions - of which Biospecimen Collection is the first listed.
NCT06075524 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT06075524 about?
NCT06075524 is a clinical study titled "Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types". This study explores the role of T cells in monitoring disease status and response during anti-PD-1/PD-L1 treatment in patients with melanoma, lung and other cancer types. Measuring levels of specific targets such as Bim and soluble PD-L1 during therapy may help track treatment resistance and clinica...
What is the current status of trial NCT06075524?
This trial is currently recruiting. The enrollment target is 500 participants. The study started on 2015-06-15. Estimated completion is 2026-12-31.
What conditions does trial NCT06075524 study?
This clinical trial studies the following conditions: Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Stage IV Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8.
What interventions are being tested in trial NCT06075524?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Electronic Health Record Review (OTHER).
Who is sponsoring clinical trial NCT06075524?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06075524 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metastatic Malignant Solid Neoplasm
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06075524's enrollment target sits among peer trials
500 5th of 92 higher than 87 of 92 other Metastatic Malignant Solid Neoplasm trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Malignant Solid Neoplasm trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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