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NCT03682289 · ClinicalTrials.gov registry record · Phase 2
Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors
A Phase 2 study of Metastatic Malignant Solid Neoplasm and Clear Cell Renal Cell Carcinoma, sponsored by Rahul Aggarwal.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 89
- Enrollment target
- 3
- Study locations
NCT03682289 is a Phase 2 study of Metastatic Malignant Solid Neoplasm and Clear Cell Renal Cell Carcinoma that is actively recruiting participants, run by Rahul Aggarwal. The registered enrollment target is 89 participants, below the 205-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (57% lower). The trial reports 3 study locations across 2 states.
The verdict
NCT03682289, a Phase 2 study of Metastatic Malignant Solid Neoplasm and Clear Cell Renal Cell Carcinoma, is actively recruiting participants, sponsored by Rahul Aggarwal.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 89 participants
- Enrollment target
- 3
- Study locations
Study Summary
This phase II trial studies how well ceralasertib, am Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor, works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, and other solid tumors excluding clear cell ovarian cancer that have spread to nearby tissue or lymph nodes or other parts of the body. ATR kinase inhibitor AZD6738 and olaparib or durvalumab may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not known if giving ATR kinase inhibitor AZD6738 with or without olaparib or durvalumab may work better in treating participants with solid tumors.
Conditions Studied
Interventions
- DRUG Olaparib
- DRUG Durvalumab
- DRUG Ceralasertib
Study Locations (3)
California
- City of Hope Comprehensive Cancer Center - Duarte
- University of California, San Francisco - San Francisco
Illinois
- University of Chicago Comprehensive Cancer Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 89 participants |
| Start Date | 2019-01-17 |
| Est. Completion | 2028-03-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03682289
The ClinicalTrials.gov registry entry for NCT03682289 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 89 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 205-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (57% lower). The listed sponsor is Rahul Aggarwal, which has 13 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Metastatic Malignant Solid Neoplasm appearing as the primary indexed condition, and to 3 interventions - of which Olaparib is the first listed.
NCT03682289 reports 3 study locations spanning 2 distinct geographic areas - top geographies include California, Illinois.
Frequently Asked Questions
What is clinical trial NCT03682289 about?
NCT03682289 is a clinical study titled "Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors". This phase II trial studies how well ceralasertib, am Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor, works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, a...
What is the current status of trial NCT03682289?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 89 participants. The study started on 2019-01-17. Estimated completion is 2028-03-31.
What conditions does trial NCT03682289 study?
This clinical trial studies the following conditions: Metastatic Malignant Solid Neoplasm, Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Metastatic Pancreatic Cancer, Metastatic Urothelial Carcinoma.
What interventions are being tested in trial NCT03682289?
The interventions under investigation include: Olaparib (DRUG), Durvalumab (DRUG), Ceralasertib (DRUG).
Who is sponsoring clinical trial NCT03682289?
This trial is sponsored by Rahul Aggarwal, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03682289 being conducted?
This trial has 3 study locations across California, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Metastatic Malignant Solid Neoplasm
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Clear Cell Renal Cell Carcinoma
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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.