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Liver Diseases
Open-data reference.
34 US clinical trials · 13 currently recruiting
Active & Recent Trials
Observational Pharmaco-Epidemiology Research & Analysis
Epividian
NCT03813862
DILIN - Prospective Study
Duke University
NCT00345930
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
European Foundation for Study of Chronic Liver Failure
NCT04613921
Genetic Collection Protocol
Arbor Research Collaborative for Health
NCT05272319
MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease
University of Chicago
NCT05264051
A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease
Indiana University
NCT05733832
Primary Sclerosing Cholangitis in Children
Arbor Research Collaborative for Health
NCT04181138
Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal
Thomas Jefferson University
NCT05470205
Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)
VA Office of Research and Development
NCT06068491
Enhancing Alcohol Treatment Engagement in Associated Liver Disease (ALD) Patients
Henry Ford Health System
NCT06269510
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Pichamol Jirapinyo, MD, MPH
NCT06138821
Safety and Efficacy of Endoscopic Ultrasound-Guided Portal Pressure Gradient Measurement
Methodist Health System
NCT06336850
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial
University of Chicago
NCT06871111
Extracellular RNA Markers of Liver Disease and Cancer
Mayo Clinic
NCT02908048
Social & Contextual Impact on Children Undergoing Liver Transplantation
University of California, San Francis
NCT04551742
Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use
University of California, San Francis
NCT05191446
Liver Cancer Prevention Randomized Control Trial
M.D. Anderson Cancer Center
NCT05196867
Implementation of a Digital Clinic for Alcohol-associated Liver Disease and Alcohol Use Disorder (DALC)
Mayo Clinic
NCT06319222
RESTORE Declined Livers Study
Washington University School of Medicine
NCT04483102
Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT03512210
Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis
Conatus Pharmaceuticals
NCT02686762
Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase
Duke University
NCT06278883
Benign Liver Optimal Core Study (Tissue Acquisition Comparison in Benign Liver Disease)
Parkview Health
NCT03245580
Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient Measurements
Cook Research Incorporated
NCT04668664
Liver Fat and Iron Quantification MRI
University of California, Los Angeles
NCT03162302
Michigan Alcohol Improvement Network- Alcohol Reduction and Treatment Trial
University of Michigan
NCT04473482
Mechanisms of Inflammatory Liver Injury
National Institute of Environmental Health Sciences (NIEHS)
NCT00011284
Breath Analysis Based Disease Biomarkers
Mayo Clinic
NCT04341012
A Study of Dasatinib to See How Liver Impaired and Healthy Subjects Process and React to the Study Drug
Bristol-Myers Squibb
NCT00382668
A Study to Test How Zongertinib is Taken up in the Blood of People With and Without Liver Problems
Boehringer Ingelheim
NCT06692322
A Phase 1, Multicenter, Open-Label Study to Evaluate the Effect of Mild or Moderate Hepatic Impairment on the Multiple-Dose Pharmacokinetics of Ozanimod
Celgene
NCT04639115
Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients
Genfit
NCT05116826
Feasibility of VIIT in Adults With NASH
Duke University
NCT03861819
Magnetic Resonance Spectroscopy (MRS) Validation Study in Individuals With Nonalcoholic Fatty Liver Disease (NAFLD)
Washington University School of Medicine
NCT00940537
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 4 |
| Phase 2 | 1 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Liver Diseases Trial Landscape
ClinicalTrials.gov lists 34 US studies indexed under Liver Diseases, and 13 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Liver Diseases shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Liver Diseases is led by Duke University with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 34 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Liver Diseases?
PlainTrial tracks 34 US clinical trials for Liver Diseases, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Liver Diseases?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.