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ClinicalTrials.gov 13 recruiting now official registry

Liver Diseases clinical trials

13 of 34 indexed Liver Diseases trials are currently recruiting.

34 US clinical trials · 13 currently recruiting

Liver Diseases is the subject of 34 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 3 of these trials.

The research picture

Liver Diseases has 34 registered US clinical trials, 13 of them open to new participants right now, about 38% of the total.

13
recruiting participants now
38%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: Duke University
Phase 14Phase 21Phase 31Phase 41

Active & Recent Trials

34 total, page 1 of 1

RECRUITING 2,000,000 participants

Observational Pharmaco-Epidemiology Research & Analysis

Epividian

NCT03813862

RECRUITING 4,000 participants

DILIN - Prospective Study

Duke University

NCT00345930

RECRUITING 3,000 participants

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

European Foundation for Study of Chronic Liver Failure

NCT04613921

RECRUITING 2,230 participants

Genetic Collection Protocol

Arbor Research Collaborative for Health

NCT05272319

RECRUITING 1,200 participants

MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease

University of Chicago

NCT05264051

RECRUITING NA 1,000 participants

A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease

Indiana University

NCT05733832

RECRUITING 1,000 participants

Primary Sclerosing Cholangitis in Children

Arbor Research Collaborative for Health

NCT04181138

RECRUITING Phase 3 660 participants

Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal

Thomas Jefferson University

NCT05470205

RECRUITING NA 450 participants

Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)

VA Office of Research and Development

NCT06068491

RECRUITING NA 268 participants

Enhancing Alcohol Treatment Engagement in Associated Liver Disease (ALD) Patients

Henry Ford Health System

NCT06269510

RECRUITING NA 132 participants

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Pichamol Jirapinyo, MD, MPH

NCT06138821

RECRUITING NA 100 participants

Safety and Efficacy of Endoscopic Ultrasound-Guided Portal Pressure Gradient Measurement

Methodist Health System

NCT06336850

RECRUITING Phase 1 24 participants

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

University of Chicago

NCT06871111

ACTIVE NOT RECRUITING 1,810 participants

Extracellular RNA Markers of Liver Disease and Cancer

Mayo Clinic

NCT02908048

ACTIVE NOT RECRUITING 500 participants

Social & Contextual Impact on Children Undergoing Liver Transplantation

University of California, San Francisco

NCT04551742

ACTIVE NOT RECRUITING NA 180 participants

Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use

University of California, San Francisco

NCT05191446

ACTIVE NOT RECRUITING NA 49 participants

Liver Cancer Prevention Randomized Control Trial

M.D. Anderson Cancer Center

NCT05196867

ACTIVE NOT RECRUITING NA 40 participants

Implementation of a Digital Clinic for Alcohol-associated Liver Disease and Alcohol Use Disorder (DALC)

Mayo Clinic

NCT06319222

ACTIVE NOT RECRUITING NA 25 participants

RESTORE Declined Livers Study

Washington University School of Medicine

NCT04483102

COMPLETED Phase 4 400 participants

Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

NCT03512210

COMPLETED Phase 2 318 participants

Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis

Conatus Pharmaceuticals

NCT02686762

COMPLETED NA 245 participants

Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase

Duke University

NCT06278883

COMPLETED NA 153 participants

Benign Liver Optimal Core Study (Tissue Acquisition Comparison in Benign Liver Disease)

Parkview Health

NCT03245580

COMPLETED 70 participants

Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient Measurements

Cook Research Incorporated

NCT04668664

COMPLETED 62 participants

Liver Fat and Iron Quantification MRI

University of California, Los Angeles

NCT03162302

COMPLETED NA 60 participants

Michigan Alcohol Improvement Network- Alcohol Reduction and Treatment Trial

University of Michigan

NCT04473482

COMPLETED 50 participants

Mechanisms of Inflammatory Liver Injury

National Institute of Environmental Health Sciences (NIEHS)

NCT00011284

COMPLETED 46 participants

Breath Analysis Based Disease Biomarkers

Mayo Clinic

NCT04341012

COMPLETED 40 participants

A Study of Dasatinib to See How Liver Impaired and Healthy Subjects Process and React to the Study Drug

Bristol-Myers Squibb

NCT00382668

COMPLETED Phase 1 29 participants

A Study to Test How Zongertinib is Taken up in the Blood of People With and Without Liver Problems

Boehringer Ingelheim

NCT06692322

COMPLETED Phase 1 26 participants

A Phase 1, Multicenter, Open-Label Study to Evaluate the Effect of Mild or Moderate Hepatic Impairment on the Multiple-Dose Pharmacokinetics of Ozanimod

Celgene

NCT04639115

COMPLETED Phase 1 25 participants

Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients

Genfit

NCT05116826

COMPLETED NA 24 participants

Feasibility of VIIT in Adults With NASH

Duke University

NCT03861819

COMPLETED 14 participants

Magnetic Resonance Spectroscopy (MRS) Validation Study in Individuals With Nonalcoholic Fatty Liver Disease (NAFLD)

Washington University School of Medicine

NCT00940537

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 1
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Liver Diseases Trial Landscape

34 indexed Liver Diseases studies · 13 recruiting (38%).

Phase mix: 2 late (III/IV) vs 5 early (I/II).

Top sponsor: Duke University (3 trials), 9 others listed. 34 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Liver Diseases?

PlainTrial tracks 34 US clinical trials for Liver Diseases, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Liver Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.