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NCT04613921 · ClinicalTrials.gov registry record
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
A clinical trial of Liver Diseases and Liver Cirrhosis, sponsored by European Foundation for Study of Chronic Liver Failure.
- Recruiting
- Registry status
- 3,000
- Enrollment target
- 20
- Study locations
NCT04613921: Recruiting study of Liver Diseases and Liver Cirrhosis, sponsored by European Foundation for Study of Chronic Liver Failure.
NCT04613921 is a study of Liver Diseases and Liver Cirrhosis that is actively recruiting participants, run by European Foundation for Study of Chronic Liver Failure. The registered enrollment target is 3,000 participants, below the 61,068-participant average among 33 other Liver Diseases trials with a reported enrollment target (95% lower). The trial reports 20 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04613921, a study of Liver Diseases and Liver Cirrhosis, is actively recruiting participants, sponsored by European Foundation for Study of Chronic Liver Failure.
- RECRUITING
- Registry status
- 3,000 participants
- Enrollment target
- 20
- Study locations
Study Summary
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-threatening complications in the donor.
Primary Outcome
survival
Conditions Studied
Interventions
- OTHER Observational Protocol
Study Locations (20)
New York
- Weill Cornell Medicine - New York
- Icahn School of Medicine at Mount Sinai - New York
- Montefiore Medical Center - New York
Texas
- Baylor College of Medicine (Scott & White) - Dallas
- Michael E DeBakey VA Medical Center - Houston
- Baylor St. Luke's Medical Centre - Houston
Illinois
- Northwestern Memorial Hospital - Chicago
- The University of Chicago Medicine - Chicago
Ohio
- University of Cincinnati - Cincinnati
- Cleveland Clinic - Cleveland
Other
- Austral University Hospital - Buenos Aires
- Hospital Alemán - Buenos Aires
California
- Cedars-Sinai Comprehensive Transplant Center - Los Angeles
Colorado
- University of Colorado - Aurora
Florida
- Tampa General Hospital - Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,000 participants |
| Start Date | 2021-07-08 |
| Est. Completion | 2026-12-31 |
What NCT04613921 shows while recruiting
NCT04613921 is an observational study that tracks outcomes without assigning an intervention. Its 3,000 participants enrollment target places it among the larger protocols in the corpus, below the 61,068-participant average among 33 other Liver Diseases trials with a reported enrollment target (95% lower).
The record links to 4 conditions, with Liver Diseases appearing as the primary indexed condition, and to 1 intervention - of which Observational Protocol is the first listed.
NCT04613921 names 20 study sites across 13 states, led by New York, Texas, Illinois.
Frequently Asked Questions
What is clinical trial NCT04613921 about?
NCT04613921 is a clinical study titled "Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs". Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to ma...
What is the current status of trial NCT04613921?
This trial is currently recruiting. The enrollment target is 3,000 participants. The study started on 2021-07-08. Estimated completion is 2026-12-31.
What conditions does trial NCT04613921 study?
This clinical trial studies the following conditions: Liver Diseases, Liver Cirrhosis, Liver Transplant, Complications, Acute-On-Chronic Liver Failure.
What interventions are being tested in trial NCT04613921?
The interventions under investigation include: Observational Protocol (OTHER).
Who is sponsoring clinical trial NCT04613921?
This trial is sponsored by European Foundation for Study of Chronic Liver Failure, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04613921 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04613921's enrollment target sits among peer trials
3,000 3rd of 33 higher than 31 of 33 other Liver Diseases trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Liver Diseases trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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