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NCT05610891 · ClinicalTrials.gov registry record · Phase 1
Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG
A Phase 1 study of High Grade Glioma, sponsored by Cellectar Biosciences.
- Active
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
- 8
- Study locations
NCT05610891: Active Phase 1 study of High Grade Glioma, sponsored by Cellectar Biosciences.
NCT05610891 is a Phase 1 study of High Grade Glioma that is active but no longer recruiting, run by Cellectar Biosciences. The registered enrollment target is 50 participants, below the 65-participant average among 42 other High Grade Glioma trials with a reported enrollment target (23% lower). The trial reports 8 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05610891, a Phase 1 study of High Grade Glioma, is active but no longer recruiting, sponsored by Cellectar Biosciences.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
- 8
- Study locations
Study Summary
The purpose of this dose finding study is to evaluate the safety and efficacy of 2 different dose levels of CLR 131 in children, adolescents and young adults with relapsed or refractory high-grade glioma (HGG).
Primary Outcome
Will be assessed by physical examination, performance status, vital signs, laboratory changes over time, and adverse events. Evaluations will use a nonparametric Wilcoxon Signed Rank test and a linear mixed effects modeling will be conducted to evaluate longitudinal changes.
Conditions Studied
Interventions
- DRUG CLR 131
Study Locations (8)
Texas
- UT Southwestern Medical Center - Dallas
- Texas Children's Cancer Center, Baylor College of Medicine - Houston
California
- Stanford University - Palo Alto
New York
- Memorial Sloan Kettering Cancer Center - New York
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Wisconsin
- University of Wisconsin, Carbone Cancer Center - Madison
Ontario
- Hospital for Sick Children - Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2023-10-01 |
| Est. Completion | 2026-09 |
| Phase | Phase 1 |
What the registry record for NCT05610891 still lists
NCT05610891 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 65-participant average among 42 other High Grade Glioma trials with a reported enrollment target (23% lower).
The record links to 1 condition, with High Grade Glioma appearing as the primary indexed condition, and to 1 intervention - of which CLR 131 is the first listed.
NCT05610891 lists 8 locations in 7 states (Texas, California, New York).
Frequently Asked Questions
What is clinical trial NCT05610891 about?
NCT05610891 is a clinical study titled "Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG". The purpose of this dose finding study is to evaluate the safety and efficacy of 2 different dose levels of CLR 131 in children, adolescents and young adults with relapsed or refractory high-grade glioma (HGG).
What is the current status of trial NCT05610891?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2023-10-01. Estimated completion is 2026-09.
What conditions does trial NCT05610891 study?
This clinical trial studies the following conditions: High Grade Glioma.
What interventions are being tested in trial NCT05610891?
The interventions under investigation include: CLR 131 (DRUG).
Who is sponsoring clinical trial NCT05610891?
This trial is sponsored by Cellectar Biosciences, which has 10 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05610891 being conducted?
This trial has 8 study locations across California, New York, Ohio, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for High Grade Glioma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05610891's enrollment target sits among peer trials
50 14th of 42 higher than 28 of 42 other High Grade Glioma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other High Grade Glioma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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