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RECRUITING Early Phase 1

Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas

NCT06829173 · View on ClinicalTrials.gov ↗

Study Summary

This is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent temozolomide based on O6-Methylguanine-DNA methyltransferase (MGMT) status for patients with newly diagnosed high grade gliomas.

Conditions Studied

Interventions

  • PROCEDURE Surgical Resection
  • RADIATION Radiation Therapy
  • DRUG XRD-0394

Study Locations (1)

New York

  • NYU Langone Health — New York

Trial Details

FieldValue
Enrollment Target 39 participants
Start Date 2025-11-05
Est. Completion 2031-05
Phase Early Phase 1

Sponsor

NYU Langone Health

1,204 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06829173

The ClinicalTrials.gov registry entry for NCT06829173 describes a study currently listed as recruiting. It is categorized as Early Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 39 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is NYU Langone Health, which has 1,204 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with High-Grade Glioma appearing as the primary indexed condition, and to 3 interventions — of which Surgical Resection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06829173 reports 1 study location spanning 1 distinct geographic area — top geographies include New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06829173 about?

NCT06829173 is a clinical study titled "Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas". This is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent temozolomide based on O6-Methylguanine-DNA methyltransferase (MGMT) status for patients with newly diagnosed high grade gli...

What is the current status of trial NCT06829173?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 39 participants. The study started on 2025-11-05. Estimated completion is 2031-05.

What conditions does trial NCT06829173 study?

This clinical trial studies the following conditions: High-Grade Glioma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06829173?

The interventions under investigation include: Surgical Resection (PROCEDURE), Radiation Therapy (RADIATION), XRD-0394 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06829173?

This trial is sponsored by NYU Langone Health, which has 1,204 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06829173 being conducted?

This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial