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RECRUITING Phase 1

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies

NCT06645886 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to learn if KQB198 works to treat advanced hematologic malignancies in adults. It will also learn about the safety of KQB198. The main questions it aims to answer are: * What is the safe dose of KQB198 by itself or in combination with other anti-cancer drugs? * Does KQB198 alone or in combination with other anti-cancer drugs decrease the size of the tumor? * What happens to KQB198 in the body? Participants will: * Take KQB198 daily, alone or in combination with another anti-cancer drug * Visit the clinic about 8 times in the first 8 weeks, and then once every 4 weeks after that

Interventions

  • DRUG Dasatinib
  • DRUG KQB198

Study Locations (20)

Texas

  • Texas Oncology Austin Central — Austin
  • MD Anderson Cancer Center — Houston

California

  • University of California, San Francisco (UCSF) — San Francisco

Colorado

  • Colorado Blood Cancer Institute — Denver

Florida

  • Moffitt Cancer Center — Tampa

Michigan

  • Barbara Ann Karmanos Cancer Institute — Detroit

North Carolina

  • Duke University Medical Center — Durham

Ohio

  • Oncology Hematology Cincinnati — Cincinnati

Tennessee

  • Sarah Cannon Research Institute (SCRI) - Transplant and Cellular Therapy Operations — Nashville

Trial Details

FieldValue
Enrollment Target 122 participants
Start Date 2024-12-09
Est. Completion 2028-02
Phase Phase 1

Sponsor

Kumquat Biosciences

32 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06645886

The ClinicalTrials.gov registry entry for NCT06645886 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 122 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kumquat Biosciences, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Hematologic Malignancies appearing as the primary indexed condition, and to 2 interventions — of which Dasatinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06645886 reports 20 study locations spanning 19 distinct geographic areas — top geographies include Texas, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06645886 about?

NCT06645886 is a clinical study titled "A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies". The goal of this clinical trial is to learn if KQB198 works to treat advanced hematologic malignancies in adults. It will also learn about the safety of KQB198. The main questions it aims to answer are: * What is the safe dose of KQB198 by itself or in combination with other anti-cancer drugs? * Do...

What is the current status of trial NCT06645886?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 122 participants. The study started on 2024-12-09. Estimated completion is 2028-02.

What conditions does trial NCT06645886 study?

This clinical trial studies the following conditions: Hematologic Malignancies, Adult. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06645886?

The interventions under investigation include: Dasatinib (DRUG), KQB198 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06645886?

This trial is sponsored by Kumquat Biosciences, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06645886 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Michigan, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial